{"id":"mk0966-duration-of-treatment-1-days","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Edema"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Cardiovascular events"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MK0966 (etoricoxib) selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for producing pro-inflammatory prostaglandins. By blocking COX-2 while sparing COX-1, the drug reduces inflammation and pain with potentially lower gastrointestinal toxicity compared to non-selective NSAIDs. The short 1-day treatment duration suggests acute pain or inflammatory indication.","oneSentence":"MK0966 is a selective COX-2 inhibitor that reduces prostaglandin production to decrease inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:21:52.133Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain"},{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[{"nctId":"NCT00390260","phase":"PHASE3","title":"Effect of Rofecoxib and a Narcotic Analgesic to Treat Pain Following Arthroscopic Surgery (0966-179)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2002-02","conditions":"Pain, Postoperative Arthroscopy","enrollment":420}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"MK0966 / Duration of Treatment: 1 Days","genericName":"MK0966 / Duration of Treatment: 1 Days","companyName":"Merck Sharp & Dohme LLC","companyId":"merck","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MK0966 is a selective COX-2 inhibitor that reduces prostaglandin production to decrease inflammation and pain. Used for Acute pain, Rheumatoid arthritis, Osteoarthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}