{"id":"mk0476-montelukast-sodium","safety":{"commonSideEffects":[{"rate":"12-18%","effect":"Headache"},{"rate":"4-6%","effect":"Influenza-like illness"},{"rate":"2-3%","effect":"Abdominal pain"},{"rate":"2-3%","effect":"Dyspepsia"},{"rate":"<1%","effect":"Neuropsychiatric events (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Leukotrienes are inflammatory mediators released during allergic and asthmatic responses that bind to cysteinyl leukotriene receptors, causing airway constriction, mucus secretion, and eosinophil recruitment. By selectively antagonizing the CysLT1 receptor, montelukast reduces these inflammatory cascades and improves airway function. This mechanism makes it effective for both asthma maintenance and acute allergic rhinitis symptoms.","oneSentence":"Montelukast sodium blocks cysteinyl leukotriene receptors (CysLT1) on airway and inflammatory cells, preventing leukotriene-mediated bronchoconstriction and inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:31.783Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (maintenance and prophylaxis)"},{"name":"Allergic rhinitis"},{"name":"Exercise-induced bronchoconstriction prophylaxis"}]},"trialDetails":[{"nctId":"NCT07101640","phase":"PHASE1, PHASE2","title":"PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia","status":"RECRUITING","sponsor":"Duke University","startDate":"2026-02-23","conditions":"Bronchopulmonary Dysplasia (BPD), Premature Births, Critical 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