{"id":"mivacurium","rwe":[{"pmid":"41808063","year":"2026","title":"Presumptive mivacurium chloride-associated histamine release resulting in overt tissue edema during endoscopic thyroidectomy: a report of two cases.","finding":"","journal":"BMC anesthesiology","studyType":"Clinical Study"},{"pmid":"41566470","year":"2026","title":"Effect and safety of mivacurium chloride and succinylcholine for bronchoscopy: study protocol for a single-center, randomized, non-inferiority, and positive-controlled clinical trial.","finding":"","journal":"Trials","studyType":"Clinical Study"},{"pmid":"41466315","year":"2025","title":"Anesthetic management of giant thyroid tumor with cardiac comorbidity causing tracheal compression: a case report.","finding":"","journal":"Journal of medical case reports","studyType":"Clinical Study"},{"pmid":"41399428","year":"2025","title":"Use of Neuromuscular Blocking Agents in Elderly Patients: A Narrative Review in Geriatric Medicine.","finding":"","journal":"International journal of general medicine","studyType":"Clinical Study"},{"pmid":"41183840","year":"2025","title":"[Comparison of the effects of continuous infusion of two doses of mivacurium in laryngeal microsurgery].","finding":"","journal":"Zhonghua yi xue za zhi","studyType":"Clinical Study"}],"tags":[{"label":"Nondepolarizing Neuromuscular Blocker","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholine receptor","category":"target"},{"label":"CHRNA1","category":"gene"},{"label":"CHRNB1","category":"gene"},{"label":"CHRND","category":"gene"},{"label":"M03AC10","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Mature","category":"status"},{"label":"General anesthesia","category":"indication"},{"label":"Muscle relaxation, function","category":"indication"},{"label":"Skeletal Muscle Relaxation for Endotracheal Intubation","category":"indication"},{"label":"Abbvie","category":"company"},{"label":"Approved 1990s","category":"decade"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Neuromuscular Blocking Agents","category":"pharmacology"},{"label":"Neuromuscular Nondepolarizing Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/neomycin","drug":"neomycin","action":"Monitor closely","effect":"May interact with Neomycin","source":"DrugCentral","drugSlug":"neomycin"},{"url":"/drug/netilmicin","drug":"netilmicin","action":"Monitor closely","effect":"May interact with Netilmicin","source":"DrugCentral","drugSlug":"netilmicin"},{"url":"/drug/streptomycin","drug":"streptomycin","action":"Monitor closely","effect":"May interact with Streptomycin","source":"DrugCentral","drugSlug":"streptomycin"},{"url":"/drug/tobramycin","drug":"tobramycin","action":"Monitor closely","effect":"May interact with Tobramycin","source":"DrugCentral","drugSlug":"tobramycin"}],"contraindications":["Acute nephropathy","Burn injury","Carcinomatosis","Deficiency of cholinesterase","Disease of liver","Disorder of cardiovascular system","End stage renal disease","Myasthenia gravis"]},"trials":[],"aliases":[],"company":"AbbVie","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MIVACURIUM","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:41:18.068465+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:41:23.595553+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MIVACURIUM","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:41:23.889092+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1182833/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:41:24.601841+00:00"}},"allNames":"mivacron","offLabel":[],"synonyms":["mivacurium","mivacurium chloride"],"timeline":[{"date":"1992-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from ABBVIE to Abbvie"},{"date":"2009-04-30","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 1 manufacturer approved"}],"aiSummary":"Mivacron (MIVACURIUM) is a nondepolarizing neuromuscular blocker developed by Abbvie, targeting the acetylcholine receptor. It is a small molecule modality, FDA-approved in 1992 for general anesthesia, muscle relaxation, and endotracheal intubation. Mivacron is off-patent, with two generic manufacturers available. Its half-life is approximately 0.83 hours, and it has 0% bioavailability. As a nondepolarizing neuromuscular blocker, Mivacron is used to facilitate endotracheal intubation and provide muscle relaxation during surgery.","brandName":"Mivacron","ecosystem":[{"indication":"General anesthesia","otherDrugs":[{"name":"acetylcysteine","slug":"acetylcysteine","company":"Apothecon"},{"name":"alfentanil","slug":"alfentanil","company":"Akorn"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"amobarbital","slug":"amobarbital","company":""}],"globalPrevalence":null},{"indication":"Muscle relaxation, function","otherDrugs":[{"name":"atracurium","slug":"atracurium","company":""},{"name":"cisatracurium","slug":"cisatracurium","company":"Abbvie"},{"name":"dimethyltubocurarinium","slug":"dimethyltubocurarinium","company":"Lilly"},{"name":"doxacurium","slug":"doxacurium","company":""}],"globalPrevalence":null},{"indication":"Skeletal Muscle Relaxation for Endotracheal 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function","source":"DrugCentral","snomedId":11977004,"regulator":"FDA"},{"name":"Skeletal Muscle Relaxation for Endotracheal Intubation","source":"DrugCentral","snomedId":"","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"currentOwner":"Abbvie","drugCategory":"mature","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book 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