{"id":"mitobronitol","rwe":[],"tags":[{"label":"mitobronitol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"L01AX01","category":"atc"},{"label":"Active","category":"status"},{"label":"Alkylating Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Alkylating","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dibromannit","offLabel":[],"synonyms":["dibromomannitol","dibromannit","dibromannitol","mielobromol","myelobromol","mitobronitol"],"timeline":[],"approvals":[],"brandName":"Dibromannit","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mitobronitol","explanation":"Imagine your cells are like power plants, generating energy for your body. Dibromannitol is like a brake on the power plant's engine, slowing down the production of energy. This can be useful in certain medical conditions, but it also means the drug can have significant side effects.","oneSentence":"Dibromannitol is thought to work by inhibiting cellular respiration, specifically targeting the electron transport chain.","technicalDetail":"Dibromannitol is believed to act as a mitochondrial complex I inhibitor, disrupting the electron transport chain and ultimately leading to a decrease in ATP production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/858","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MITOBRONITOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:03:35.856575","biosimilars":[],"competitors":[{"drugName":"pipobroman","drugSlug":"pipobroman","fdaApproval":"1966-07-01","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"temozolomide","drugSlug":"temozolomide","fdaApproval":"1999-08-11","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dacarbazine","drugSlug":"dacarbazine","fdaApproval":"1975-05-27","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"mitobronitol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"pipobroman","brandName":"pipobroman","genericName":"pipobroman","approvalYear":"1966","relationship":"same-class"},{"drugId":"temozolomide","brandName":"temozolomide","genericName":"temozolomide","approvalYear":"1999","relationship":"same-class"},{"drugId":"dacarbazine","brandName":"dacarbazine","genericName":"dacarbazine","approvalYear":"1975","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000168408","NDDF":"004464","UNII":"5UP30YED7N","CHEBI":"CHEBI:34853","INN_ID":"2454","RXNORM":"203009","UMLSCUI":"C0026236","ChEMBL_ID":"CHEMBL447629","KEGG_DRUG":"D02020","DRUGBANK_ID":"DB13543","PUBCHEM_CID":"656655","SNOMEDCT_US":"29089004","MESH_DESCRIPTOR_UI":"D008927"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":13,"therapeuticAreas":["Respiratory"],"atcClassification":{"source":"DrugCentral","atcCode":"L01AX01","allCodes":["L01AX01"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dibromannitol, also known as mitobronitol, is a small molecule drug of the mitobronitol class. Its original development is unclear, and its current owner is also unknown. The target of dibromannitol is not specified, and it has not been approved by the FDA for any indications. The commercial status of dibromannitol, including whether it is patented or generic, is also unknown. As a result, key safety considerations and pharmacological details are not well-documented.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}