{"id":"misoprostol-modified-release-pessary","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fever"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol acts as a synthetic prostaglandin that stimulates uterine smooth muscle contraction and softens the cervix by increasing local prostaglandin receptor signaling. The modified-release pessary formulation delivers the drug directly to the uterus over an extended period, allowing sustained local effects while minimizing systemic exposure. This mechanism facilitates labor induction and cervical preparation in obstetric settings.","oneSentence":"Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:23.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening and labor induction in term pregnancy"}]},"trialDetails":[{"nctId":"NCT02539199","phase":"PHASE4","title":"Vaginally Administered Versus Per Oral Misoprostol in Induction of Labour","status":"COMPLETED","sponsor":"Tampere University Hospital","startDate":"2015-09","conditions":"Labour Induction","enrollment":270}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Misodel"],"phase":"marketed","status":"active","brandName":"Misoprostol, modified-release pessary","genericName":"Misoprostol, modified-release pessary","companyName":"Tampere University Hospital","companyId":"tampere-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation. Used for Cervical ripening and labor induction in term pregnancy, Medical management of miscarriage or abortion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}