{"id":"misoprostol-given-vaginally","safety":{"commonSideEffects":[{"rate":"60-80","effect":"Uterine contractions/cramping"},{"rate":"40-60","effect":"Vaginal bleeding"},{"rate":"15-30","effect":"Diarrhea"},{"rate":"10-20","effect":"Nausea"},{"rate":"10-15","effect":"Fever"},{"rate":"5-10","effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol acts as a synthetic prostaglandin that stimulates uterine smooth muscle contraction and softens the cervix by increasing local prostaglandin receptor signaling. When administered vaginally, it achieves high local concentrations that promote labor induction and cervical preparation. This mechanism makes it effective for medical abortion and labor induction in obstetric settings.","oneSentence":"Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:20.282Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical ripening and labor induction"},{"name":"Medical abortion (in combination with mifepristone)"}]},"trialDetails":[{"nctId":"NCT07422506","phase":"NA","title":"A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion","status":"RECRUITING","sponsor":"The Third Xiangya Hospital of Central South University","startDate":"2024-01-01","conditions":"Missed Abortion, Early Pregnancy Failure","enrollment":580},{"nctId":"NCT07160855","phase":"PHASE4","title":"Letrozole Plus Misoprostol Versus Misoprostol Alone for Treating Women With Missed Miscarriage","status":"RECRUITING","sponsor":"Nishtar Medical University","startDate":"2025-05-13","conditions":"Miscarriage in First Trimester, Missed Miscarriage","enrollment":92},{"nctId":"NCT05304273","phase":"PHASE3","title":"Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages","status":"UNKNOWN","sponsor":"Calcutta National Medical College and Hospital","startDate":"2022-05-05","conditions":"Miscarriage","enrollment":120},{"nctId":"NCT02777190","phase":"PHASE4","title":"A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor","status":"TERMINATED","sponsor":"Milton S. Hershey Medical Center","startDate":"2017-11-01","conditions":"Labor; Forced or Induced, Affecting Fetus or Newborn, Pregnancy","enrollment":34},{"nctId":"NCT04339348","phase":"PHASE3","title":"Comparative Safety and Efficacy of Vaginal Misoprostol Versus Lidocaine-prilocaine Cream in Levonorgestrel IUD Insertion","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-04-30","conditions":"Contraception","enrollment":210},{"nctId":"NCT03682718","phase":"PHASE4","title":"Vaginal Misoprostol With Intracervical Foley Catheter in Induction of Labor","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-10-01","conditions":"Induction of Labor Affected Fetus / Newborn","enrollment":120},{"nctId":"NCT04590482","phase":"PHASE4","title":"Letrozole Pretreatment With Misoprostol Induction of Abortion in First Trimester Missed Abortion","status":"UNKNOWN","sponsor":"Shereen Rady Abou El-fetouh","startDate":"2020-11-15","conditions":"Missed Abortion","enrollment":110},{"nctId":"NCT01615211","phase":"PHASE2","title":"Randomized Study of Letrozole and Trilostane for Medical Abortion","status":"TERMINATED","sponsor":"Kristina Gemzell Danielsson","startDate":"2012-05","conditions":"Medical Abortion, Complete or Unspecified, Without Complication","enrollment":36},{"nctId":"NCT01805115","phase":"PHASE3","title":"Misoprostol Administration Before Operative Hysteroscopy","status":"COMPLETED","sponsor":"CHA University","startDate":"2013-03","conditions":"Endometrial Disorder","enrollment":120},{"nctId":"NCT00892229","phase":"PHASE2","title":"Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil","status":"COMPLETED","sponsor":"Hawler Medical University","startDate":"2007-03","conditions":"Missed Abortion","enrollment":100},{"nctId":"NCT00797693","phase":"NA","title":"Misoprostol in Termination of First Trimester Missed Abortion","status":"COMPLETED","sponsor":"Hawler Medical University","startDate":"2008-01","conditions":"Miscarriage","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["serial number 022-00","Cytotec","Arthrotec"],"phase":"marketed","status":"active","brandName":"Misoprostol (given vaginally)","genericName":"Misoprostol (given vaginally)","companyName":"Hawler Medical University","companyId":"hawler-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Misoprostol is a prostaglandin E1 analogue that binds to prostaglandin receptors to increase uterine contractions and promote cervical ripening and dilation. Used for Cervical ripening and labor induction, Medical abortion (in combination with mifepristone), Prevention of postpartum hemorrhage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}