{"id":"misoprostol-400-microgram-oral-tablet","safety":{"commonSideEffects":[{"rate":"13-40","effect":"Diarrhea"},{"rate":"7-20","effect":"Abdominal pain"},{"rate":"3-7","effect":"Nausea"},{"rate":"2-5","effect":"Flatulence"},{"rate":null,"effect":"Uterine cramping"},{"rate":"2-3","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors in the gastric mucosa, enhancing protective mechanisms against acid-induced injury. It also promotes gastric blood flow and accelerates mucosal healing. Additionally, it has uterotonic properties that increase uterine contractions, which is why it is used both for gastrointestinal protection and for obstetric indications.","oneSentence":"Misoprostol is a prostaglandin E1 analogue that increases gastric mucus production and bicarbonate secretion while reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:22.345Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers"},{"name":"Treatment of gastric ulcers"},{"name":"Medical abortion (in combination with mifepristone)"},{"name":"Induction of labor"}]},"trialDetails":[{"nctId":"NCT06049745","phase":"PHASE4","title":"Use of Misoprostol in Hysteroscopic Myomectomy","status":"NOT_YET_RECRUITING","sponsor":"Assuta Ashdod Hospital","startDate":"2023-11","conditions":"Hysteroscopic Myomectomy","enrollment":200},{"nctId":"NCT02412618","phase":"PHASE4","title":"Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation","status":"COMPLETED","sponsor":"Medstar Health Research Institute","startDate":"2012-09","conditions":"Induced Abortion","enrollment":100},{"nctId":"NCT05046041","phase":"PHASE4","title":"Assessing Outpatient 'Day Procedure' for Second-trimester Medical Abortion at Two Public Sector Hospitals in Nepal","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2020-11-25","conditions":"Abortion in Second Trimester","enrollment":120},{"nctId":"NCT03346629","phase":"PHASE4","title":"Outpatient Service for Mid-trimester Termination of Pregnancy","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2017-12-01","conditions":"Abortion in Second Trimester","enrollment":230},{"nctId":"NCT03140033","phase":"PHASE2","title":"Sublingual Misoprostol to Reduce Blood Loss During Elective Cesarean Delivery","status":"UNKNOWN","sponsor":"Ain Shams Maternity Hospital","startDate":"2016-07","conditions":"Hemorrhage Postpartum","enrollment":158},{"nctId":"NCT02522130","phase":"NA","title":"Different Analgesics Prior to Intrauterine Device (IUD) Insertion: Is There Any Evidence?","status":"UNKNOWN","sponsor":"Al Hayat National Hospital","startDate":"2015-07","conditions":"IUD Insertion Complication","enrollment":200},{"nctId":"NCT00594854","phase":"PHASE3","title":"Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers in High Risk Subjects Compared to Arthrotec","status":"TERMINATED","sponsor":"POZEN","startDate":"2007-09","conditions":"Gastric Ulcer","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Misoprostol 400 Microgram Oral Tablet","genericName":"Misoprostol 400 Microgram Oral Tablet","companyName":"Assuta Ashdod Hospital","companyId":"assuta-ashdod-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Misoprostol is a prostaglandin E1 analogue that increases gastric mucus production and bicarbonate secretion while reducing gastric acid secretion. Used for Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers, Treatment of gastric ulcers, Medical abortion (in combination with mifepristone).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}