{"id":"mirtazapine-snris","safety":{"commonSideEffects":[{"rate":"54","effect":"Sedation"},{"rate":"17","effect":"Weight gain"},{"rate":"17","effect":"Increased appetite"},{"rate":"7","effect":"Dizziness"},{"rate":"25","effect":"Dry mouth"},{"rate":"13","effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL654","moleculeType":"Small molecule","molecularWeight":"265.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mirtazapine enhances noradrenergic and serotonergic activity in the central nervous system through presynaptic alpha-2 antagonism and postsynaptic 5-HT2/5-HT3 receptor antagonism. This dual mechanism increases the release and availability of norepinephrine and serotonin, which are implicated in mood regulation. The drug is distinct from SNRIs (serotonin-norepinephrine reuptake inhibitors) in its mechanism, though both classes are used for similar psychiatric indications.","oneSentence":"Mirtazapine is a tetracyclic antidepressant that blocks alpha-2 adrenergic receptors and serotonin 5-HT2 and 5-HT3 receptors, increasing norepinephrine and serotonin neurotransmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:20.622Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Anxiety disorders"},{"name":"Insomnia (off-label)"}]},"trialDetails":[{"nctId":"NCT04437485","phase":"PHASE2","title":"eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk","status":"COMPLETED","sponsor":"Indiana University","startDate":"2020-10-14","conditions":"Depression, Major Depressive Disorder, Dysthymic Disorder","enrollment":46},{"nctId":"NCT05889234","phase":"","title":"Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort Study","status":"UNKNOWN","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2023-11-06","conditions":"Major Depressive Disorder, Magnetic Resonance Imaging, Electroconvulsive Therapy","enrollment":180},{"nctId":"NCT05952713","phase":"","title":"Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder","status":"COMPLETED","sponsor":"Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital","startDate":"2022-10-01","conditions":"Major Depressive Disorder","enrollment":73336},{"nctId":"NCT03219008","phase":"PHASE4","title":"Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics","status":"UNKNOWN","sponsor":"Shanghai Mental Health Center","startDate":"2017-08-01","conditions":"Depressive Disorder","enrollment":800},{"nctId":"NCT00612807","phase":"PHASE1, PHASE2","title":"Treatment of Mood and Marriage Study (TOMMS)","status":"COMPLETED","sponsor":"Duke University","startDate":"2006-07","conditions":"Major Depressive Disorder, Partner Relational Disorder (V61.10)","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Mirtazapine/SNRIs","genericName":"Mirtazapine/SNRIs","companyName":"Shanghai Mental Health Center","companyId":"shanghai-mental-health-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mirtazapine is a tetracyclic antidepressant that blocks alpha-2 adrenergic receptors and serotonin 5-HT2 and 5-HT3 receptors, increasing norepinephrine and serotonin neurotransmission. Used for Major depressive disorder, Off-label use in anxiety disorders, insomnia, and appetite stimulation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}