{"id":"mirasol-treated-fresh-whole-blood","safety":{"commonSideEffects":[{"rate":null,"effect":"Transfusion-related acute lung injury (TRALI)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Hemolytic transfusion reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The Mirasol pathogen reduction technology involves treating blood with riboflavin (vitamin B2) and ultraviolet A light, which generates reactive oxygen species that damage nucleic acids in pathogens and leukocytes. This process reduces the risk of transfusion-transmitted infections and transfusion-related acute lung injury (TRALI) while maintaining the hemostatic function of the blood product.","oneSentence":"Mirasol treatment uses riboflavin and ultraviolet light to inactivate pathogens and reduce white blood cells in fresh whole blood for transfusion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:04.018Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fresh whole blood for transfusion with reduced risk of pathogen transmission and TRALI"}]},"trialDetails":[{"nctId":"NCT03737669","phase":"PHASE3","title":"Mirasol Evaluation of Reduction in Infections Trial","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2019-11-13","conditions":"Transfusion-Transmitted Infectious Disease","enrollment":2000},{"nctId":"NCT02330081","phase":"NA","title":"Survival and Recovery of Radio-labeled Platelets Derived From Mirasol-treated Whole Blood","status":"COMPLETED","sponsor":"Terumo BCTbio","startDate":"2015-04","conditions":"Blood Safety","enrollment":22},{"nctId":"NCT02118428","phase":"NA","title":"Clinical and Biological Efficacy of Mirasol-treated Fresh Whole Blood for the Prevention of Transfusion-transmitted Malaria","status":"COMPLETED","sponsor":"Terumo BCTbio","startDate":"2014-03","conditions":"Malaria","enrollment":227}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Mirasol-treated Fresh Whole Blood","genericName":"Mirasol-treated Fresh Whole Blood","companyName":"Johns Hopkins University","companyId":"johns-hopkins-university","modality":"Biologic","firstApprovalDate":"","aiSummary":"Mirasol treatment uses riboflavin and ultraviolet light to inactivate pathogens and reduce white blood cells in fresh whole blood for transfusion. Used for Fresh whole blood for transfusion with reduced risk of pathogen transmission and TRALI.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}