{"id":"miocamycin","rwe":[{"pmid":"23489645","year":"2013","title":"Miocamycin-containing triple therapy for H. pylori infection.","finding":"","journal":"Helicobacter","studyType":"Clinical Study"},{"pmid":"19747296","year":"2009","title":"Linear IgA bullous dermatosis of childhood: successful treatment with miocamycin and topical corticosteroid.","finding":"","journal":"Clinical and experimental dermatology","studyType":"Clinical Study"},{"pmid":"16120627","year":"2005","title":"Resistance to macrolides, clindamycin and telithromycin in Streptococcus pyogenes isolated in Spain during 2004.","finding":"","journal":"The Journal of antimicrobial chemotherapy","studyType":"Clinical Study"},{"pmid":"14616688","year":"2003","title":"Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis.","finding":"","journal":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases","studyType":"Clinical Study"},{"pmid":"12878546","year":"2003","title":"Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A).","finding":"","journal":"Antimicrobial agents and chemotherapy","studyType":"Clinical Study"}],"tags":[{"label":"miocamycin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01FA11","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acecamycin","offLabel":[],"synonyms":["miokamycin","acecamycin","midecamycin acetate","miocamycin","ponsinomycin"],"timeline":[],"approvals":[],"brandName":"Acecamycin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"miocamycin","explanation":"Think of it like a factory assembly line: miocamycin blocks the assembly of proteins, which are crucial for bacterial growth and survival. Without these proteins, the bacteria can't function properly and eventually die. This mechanism is specific to bacteria and doesn't affect human cells, which is why miocamycin is used as an antibiotic.","oneSentence":"Miocamycin works by binding to the bacterial ribosome and preventing the synthesis of essential proteins.","technicalDetail":"Miocamycin binds to the 50S subunit of the bacterial ribosome, specifically to the 23S rRNA, and inhibits the translocation step of protein synthesis, preventing the formation of peptide bonds and ultimately leading to the degradation of the bacterial mRNA."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Miocamycin","title":"Miocamycin","extract":"Miocamycin is a macrolide antibiotic. It has a spectrum activity similar to that of Erythromycin, but shows higher antimicrobial effect against certain bacteria including Legionella pneumophila, Mycoplasma hominis, and Ureaplasma urealyticum. In-vivo studies have further expounded on Miocamycin's efficacy, reporting that the medication is more effective than in-vitro data suggests."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1815","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=miocamycin","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Miocamycin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:32:19.752346","biosimilars":[],"competitors":[{"drugName":"erythromycin","drugSlug":"erythromycin","fdaApproval":"1964-06-24","genericCount":39,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"troleandomycin","drugSlug":"troleandomycin","fdaApproval":"1969-05-27","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clarithromycin","drugSlug":"clarithromycin","fdaApproval":"1991-10-31","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azithromycin","drugSlug":"azithromycin","fdaApproval":"1991-11-01","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dirithromycin","drugSlug":"dirithromycin","fdaApproval":"1995-06-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"telithromycin","drugSlug":"telithromycin","fdaApproval":"2004-04-01","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"miocamycin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"erythromycin","brandName":"erythromycin","genericName":"erythromycin","approvalYear":"1964","relationship":"same-class"},{"drugId":"troleandomycin","brandName":"troleandomycin","genericName":"troleandomycin","approvalYear":"1969","relationship":"same-class"},{"drugId":"clarithromycin","brandName":"clarithromycin","genericName":"clarithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"azithromycin","brandName":"azithromycin","genericName":"azithromycin","approvalYear":"1991","relationship":"same-class"},{"drugId":"dirithromycin","brandName":"dirithromycin","genericName":"dirithromycin","approvalYear":"1995","relationship":"same-class"},{"drugId":"telithromycin","brandName":"telithromycin","genericName":"telithromycin","approvalYear":"2004","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000168430","NDDF":"004200","UNII":"3T48CPS7U2","CHEBI":"CHEBI:31846","RXNORM":"236200","UMLSCUI":"C0026202","ChEMBL_ID":"CHEMBL1091024","KEGG_DRUG":"D01636","DRUGBANK_ID":"DB13287","PUBCHEM_CID":"5282188","SNOMEDCT_US":"734560006","MESH_DESCRIPTOR_UI":"D015644"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":113,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01FA11","allCodes":["J01FA11"]},"biosimilarFilings":[],"recentPublications":[{"date":"2013 Aug","pmid":"23489645","title":"Miocamycin-containing triple therapy for H. pylori infection.","journal":"Helicobacter"},{"date":"2009 Oct","pmid":"19747296","title":"Linear IgA bullous dermatosis of childhood: successful treatment with miocamycin and topical corticosteroid.","journal":"Clinical and experimental dermatology"},{"date":"2005 Oct","pmid":"16120627","title":"Resistance to macrolides, clindamycin and telithromycin in Streptococcus pyogenes isolated in Spain during 2004.","journal":"The Journal of antimicrobial chemotherapy"},{"date":"2003 Sep","pmid":"14616688","title":"Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis.","journal":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"date":"2003 Aug","pmid":"12878546","title":"Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A).","journal":"Antimicrobial agents and chemotherapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Acecamycin is a small molecule with synonyms including 3'',9-DIACETYLMYDECAMYCIN, 9,3''-DI-O-ACETYLMIDECAMYCIN, and Miocamycin. It is a macrolide antibiotic with a spectrum of activity similar to Erythromycin, effective against bacteria such as Legionella pneumophila, Mycoplasma hominis, and Ureaplasma urealyticum.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}