{"id":"minoxidil-lotion-2","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Scalp irritation or dermatitis"},{"rate":"1-5","effect":"Hypertrichosis (unwanted hair growth on adjacent skin)"},{"rate":"3-10","effect":"Dryness or flaking of scalp"},{"rate":"2-8","effect":"Itching or burning sensation"}]},"_chembl":{"chemblId":"CHEMBL802","moleculeType":"Small molecule","molecularWeight":"209.25"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Minoxidil acts as a vasodilator by opening ATP-sensitive potassium channels, which increases cutaneous blood flow to hair follicles and delivers more nutrients and oxygen to the dermal papilla. This stimulation extends the anagen phase and increases hair shaft diameter, promoting hair growth and delaying hair loss. The exact mechanism of action on hair follicles remains incompletely understood but is distinct from its original use as an oral antihypertensive agent.","oneSentence":"Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:19.589Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Androgenetic alopecia (male and female pattern hair loss)"},{"name":"Hair regrowth promotion in topical form"}]},"trialDetails":[{"nctId":"NCT01672307","phase":"PHASE4","title":"Minoxidil 2% for Eyebrow Enhancement","status":"COMPLETED","sponsor":"Mae Fah Luang University Hospital","startDate":"2012-09","conditions":"Hypotrichosis of Eyebrows, Thinning Eyebrows","enrollment":40},{"nctId":"NCT01391156","phase":"PHASE3","title":"Efficacy Study of Minoxidil Lotion Versus Combined Minoxidil and Finasteride Lotion to Treat Male Pattern Hair Loss","status":"COMPLETED","sponsor":"Mae Fah Luang University Hospital","startDate":"2011-03","conditions":"Androgenetic Alopecia","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Minoxidil lotion 2%","genericName":"Minoxidil lotion 2%","companyName":"Mae Fah Luang University Hospital","companyId":"mae-fah-luang-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Minoxidil is a potassium channel opener that increases blood flow to hair follicles and prolongs the anagen (growth) phase of the hair cycle. Used for Androgenetic alopecia (male and female pattern hair loss).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}