{"id":"minocycline-plus-tretinoin","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Skin irritation and peeling (tretinoin)"},{"rate":null,"effect":"Dizziness or vertigo (minocycline)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vaginal yeast infection"}]},"_chembl":{"chemblId":"CHEMBL1200881","moleculeType":"Small molecule","molecularWeight":"493.94"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Minocycline inhibits bacterial protein synthesis and has immunomodulatory effects that reduce inflammatory cytokines and neutrophil activity. Tretinoin normalizes keratinization, increases cell turnover, and reduces comedone formation. The combination addresses multiple pathogenic factors in acne: bacterial colonization, inflammation, and abnormal follicular keratinization.","oneSentence":"Minocycline is a tetracycline antibiotic with anti-inflammatory properties, while tretinoin is a retinoid that promotes skin cell turnover and reduces sebum production; together they target bacterial infection and inflammation in acne.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:19.273Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT04940767","phase":"PHASE4","title":"A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris","status":"COMPLETED","sponsor":"Edward Lain, MD","startDate":"2021-06-28","conditions":"Acne Vulgaris","enrollment":31},{"nctId":"NCT05077813","phase":"PHASE2","title":"Utilizing the Crosstalk Among Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized), Minocycline and Vitamin D as a Potent Quadrate Therapy for Treating Patients With Multidrug-resistant TB and Patient With Both Multidrug-resistant TB and COVID-19","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2021-12","conditions":"Tuberculosis","enrollment":250},{"nctId":"NCT00240513","phase":"PHASE4","title":"Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin","status":"TERMINATED","sponsor":"Derm Research @ 888 Inc.","startDate":"2004-08","conditions":"Acne Vulgaris","enrollment":38},{"nctId":"NCT01206348","phase":"PHASE4","title":"Combination Treatment for Moderate to Severe Acne","status":"COMPLETED","sponsor":"Medicis Global Service Corporation","startDate":"2010-09","conditions":"Acne","enrollment":97}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Minocin","Tretinoin"],"phase":"marketed","status":"active","brandName":"Minocycline plus tretinoin","genericName":"Minocycline plus tretinoin","companyName":"Derm Research @ 888 Inc.","companyId":"derm-research-888-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Minocycline is a tetracycline antibiotic with anti-inflammatory properties, while tretinoin is a retinoid that promotes skin cell turnover and reduces sebum production; together they target bacterial infection and normalize keratinization in acne. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}