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This targeted delivery reduces pathogenic bacteria and inflammatory mediators associated with periodontitis.","oneSentence":"Minocycline HCl microspheres deliver the antibiotic minocycline directly into periodontal pockets to inhibit bacterial growth and reduce inflammation in periodontal disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:09.775Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic periodontitis (adjunctive to scaling and root planing)"}]},"trialDetails":[{"nctId":"NCT07298057","phase":"EARLY_PHASE1","title":"Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics","status":"RECRUITING","sponsor":"Case Western Reserve University","startDate":"2026-02-06","conditions":"Periodontitis, Diabetes Mellitus Type 2","enrollment":42},{"nctId":"NCT05422742","phase":"NA","title":"Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities","status":"ACTIVE_NOT_RECRUITING","sponsor":"West Virginia University","startDate":"2021-10-15","conditions":"Periodontitis","enrollment":50},{"nctId":"NCT03762915","phase":"PHASE4","title":"Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2019-05-20","conditions":"SRP, Minocycline HCl Microspheres, Biomarkers","enrollment":70},{"nctId":"NCT01647282","phase":"PHASE4","title":"Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2012-10-01","conditions":"Moderate to Advanced Chronic Periodontitis","enrollment":60},{"nctId":"NCT04312542","phase":"","title":"Systemic Markers of Inflammation: 9- and 12-Month Follow-Up Post Non-Surgical Periodontal Therapy","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2020-07-21","conditions":"SRP, Minocycline HCl Microspheres, Biomarkers","enrollment":60},{"nctId":"NCT03964935","phase":"PHASE2","title":"Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment","status":"UNKNOWN","sponsor":"University of Baghdad","startDate":"2018-12-01","conditions":"Periodontal Pocket","enrollment":30},{"nctId":"NCT01802216","phase":"NA","title":"Kidney and Periodontal Disease Study","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2014-02","conditions":"Chronic Kidney Disease, Periodontal Disease","enrollment":51},{"nctId":"NCT01517334","phase":"PHASE3","title":"Arestin - Use in Subjects With Peri-Implantitis (With Subgingival Microbiological Evaluation)","status":"COMPLETED","sponsor":"OraPharma","startDate":"2012-05","conditions":"Peri-Implantitis","enrollment":208},{"nctId":"NCT01539564","phase":"PHASE3","title":"Arestin - Use in Subjects With Peri-Implantitis","status":"COMPLETED","sponsor":"OraPharma","startDate":"2012-04","conditions":"Peri-Implantitis","enrollment":215},{"nctId":"NCT00668746","phase":"PHASE4","title":"Long-term Safety of Minocycline in Patients With Gum Disease","status":"COMPLETED","sponsor":"OraPharma","startDate":"2007-12","conditions":"Periodontitis","enrollment":35},{"nctId":"NCT00662532","phase":"PHASE3","title":"Antibiotic Study for Dental Implants","status":"COMPLETED","sponsor":"OraPharma","startDate":"2008-04","conditions":"Periodontitis","enrollment":44},{"nctId":"NCT00392223","phase":"PHASE3","title":"Efficacy And Safety Of Azithromycin SR Compared With Minocycline In Acne","status":"TERMINATED","sponsor":"Pfizer","startDate":"2007-10","conditions":"Acne Vulgaris","enrollment":118},{"nctId":"NCT00371332","phase":"PHASE3","title":"Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis","status":"COMPLETED","sponsor":"OraPharma","startDate":"2004-01","conditions":"Periodontitis","enrollment":128}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Arestin (brand name)","minocycline","Arestin"],"phase":"marketed","status":"active","brandName":"Minocycline HCl Microspheres","genericName":"Minocycline HCl Microspheres","companyName":"OraPharma","companyId":"orapharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Minocycline HCl microspheres deliver the antibiotic minocycline directly into periodontal pockets to inhibit bacterial growth and reduce inflammation in periodontal disease. Used for Chronic periodontitis (adjunctive to scaling and root planing).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}