{"id":"minocyclin","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"common","organSystem":""},{"effect":"Diarrhea","drugRate":"","severity":"common","organSystem":""},{"effect":"Dyspepsia","drugRate":"","severity":"common","organSystem":""},{"effect":"Anorexia","drugRate":"","severity":"common","organSystem":""},{"effect":"Headache","drugRate":"","severity":"common","organSystem":""},{"effect":"Dizziness","drugRate":"","severity":"common","organSystem":""},{"effect":"Vertigo","drugRate":"","severity":"common","organSystem":""},{"effect":"Rash","drugRate":"","severity":"common","organSystem":""},{"effect":"Pruritus","drugRate":"","severity":"common","organSystem":""},{"effect":"Maculopapular rash","drugRate":"","severity":"common","organSystem":""},{"effect":"Erythematous rash","drugRate":"","severity":"common","organSystem":""},{"effect":"Urticaria","drugRate":"","severity":"common","organSystem":""},{"effect":"Stomatitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Glossitis","drugRate":"","severity":"common","organSystem":""},{"effect":"Cough","drugRate":"","severity":"common","organSystem":""},{"effect":"Dyspnea","drugRate":"","severity":"common","organSystem":""},{"effect":"Arthralgia","drugRate":"","severity":"common","organSystem":""},{"effect":"Myalgia","drugRate":"","severity":"common","organSystem":""},{"effect":"Fever","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Azotemia","Benign intracranial hypertension","Breastfeeding (mother)","Disease of liver","Esophageal dysmotility","Kidney disease","Pregnancy, function","Pseudomembranous enterocolitis"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[{"effect":"Stevens-Johnson syndrome","drugRate":"","severity":"serious"},{"effect":"Toxic epidermal necrolysis","drugRate":"","severity":"serious"},{"effect":"Anaphylaxis/anaphylactoid reaction","drugRate":"","severity":"serious"},{"effect":"Fatal hepatic failure","drugRate":"","severity":"serious"},{"effect":"Pseudotumor cerebri (benign intracranial hypertension)","drugRate":"","severity":"serious"},{"effect":"Reversible acute renal failure","drugRate":"","severity":"serious"},{"effect":"Thyroid cancer","drugRate":"","severity":"serious"},{"effect":"Hypersensitivity syndrome","drugRate":"","severity":"serious"},{"effect":"Lupus-like syndrome","drugRate":"","severity":"serious"},{"effect":"Pneumonitis","drugRate":"","severity":"serious"}]},"trials":[],"_chembl":{"chemblId":"CHEMBL1200881","moleculeType":"Small molecule","molecularWeight":"493.94"},"aliases":["Minocycline HCL 200mg Daily (Oral or Intravenous)"],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"_dailymed":{"setId":"409dddb0-be3a-4ae3-ab39-88a6cd50a219","title":"MINOCYCLINE HYDROCHLORIDE TABLET, FILM COATED, EXTENDED RELEASE [BRYANT RANCH PREPACK]"},"ecosystem":[],"mechanism":{"target":"30S ribosomal protein S4, 30S ribosomal protein S9, Tetracycline resistance protein, class B"},"_scrapedAt":"2026-03-28T01:21:30.599Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"indications":{"approved":[{"name":"Acne vulgaris","diseaseId":"acne-vulgaris","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Actinomycotic infection","diseaseId":"actinomycotic-infection","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Acute gonococcal cervicitis","diseaseId":"acute-gonococcal-cervicitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Acute gonococcal endometritis","diseaseId":"acute-gonococcal-endometritis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Acute gonococcal urethritis","diseaseId":"acute-gonococcal-urethritis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Anthrax","diseaseId":"anthrax","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Bartonellosis","diseaseId":"bartonellosis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Bronchitis","diseaseId":"bronchitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Brucellosis","diseaseId":"brucellosis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Chancroid","diseaseId":"chancroid","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Chlamydia trachomatis infection of genital structure","diseaseId":"chlamydia-trachomatis-infection-of-genital-structure","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Cholera","diseaseId":"cholera","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Fusospirochetal pharyngitis","diseaseId":"fusospirochetal-pharyngitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Gingivostomatitis","diseaseId":"gingivostomatitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Gonorrhea","diseaseId":"gonorrhea","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Gonorrhea of pharynx","diseaseId":"gonorrhea-of-pharynx","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Gonorrhea of rectum","diseaseId":"gonorrhea-of-rectum","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Granuloma inguinale","diseaseId":"granuloma-inguinale","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Inclusion conjunctivitis","diseaseId":"inclusion-conjunctivitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Infection by Campylobacter fetus","diseaseId":"infection-by-campylobacter-fetus","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Infection of skin AND/OR subcutaneous tissue","diseaseId":"infection-of-skin-and/or-subcutaneous-tissue","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Infective otitis media","diseaseId":"infective-otitis-media","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Listeriosis","diseaseId":"listeriosis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Lymphogranuloma venereum","diseaseId":"lymphogranuloma-venereum","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Meningococcus carrier","diseaseId":"meningococcus-carrier","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Ornithosis","diseaseId":"ornithosis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Periodontitis","diseaseId":"periodontitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Pharyngitis","diseaseId":"pharyngitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Plague","diseaseId":"plague","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Pneumonia","diseaseId":"pneumonia","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Q fever","diseaseId":"q-fever","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Rectal Chlamydia Trachomatis Infection","diseaseId":"rectal-chlamydia-trachomatis-infection","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Relapsing fever","diseaseId":"relapsing-fever","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Rickettsialpox","diseaseId":"rickettsialpox","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Rocky Mountain spotted fever","diseaseId":"rocky-mountain-spotted-fever","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Sinusitis","diseaseId":"sinusitis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Syphilis","diseaseId":"syphilis","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Trachoma","diseaseId":"trachoma","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Tularemia","diseaseId":"tularemia","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Typhus Infections","diseaseId":"typhus-infections","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Ureaplasma Urealyticum Infections","diseaseId":"ureaplasma-urealyticum-infections","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Urinary tract infectious disease","diseaseId":"urinary-tract-infectious-disease","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Yaws","diseaseId":"yaws","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03947827","phase":"PHASE3","title":"Minocycline as Adjunctive Treatment for Treatment Resistant Depression","status":"COMPLETED","sponsor":"Centre for Addiction and Mental Health","startDate":"2020-02-01","conditions":"Treatment Resistant Depression","enrollment":76},{"nctId":"NCT06561711","phase":"PHASE4","title":"Optimization of Minocycline for Helicobacter Pylori Rescue Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2024-08-21","conditions":"Helicobacter Pylori Infection","enrollment":480},{"nctId":"NCT07237048","phase":"PHASE2, PHASE3","title":"Minocycline in Stroke Study at Maimonides","status":"RECRUITING","sponsor":"Joyce Chen","startDate":"2026-02-02","conditions":"Stroke, Ischemia Stroke, Hemorrhagic Strokes","enrollment":1164},{"nctId":"NCT07239739","phase":"NA","title":"Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","status":"NOT_YET_RECRUITING","sponsor":"Faiz ur rahman","startDate":"2026-06-15","conditions":"Periapical Lesion, Periapical Periodontitis","enrollment":62},{"nctId":"NCT06120140","phase":"PHASE2","title":"Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2024-02-16","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":300},{"nctId":"NCT07462702","phase":"EARLY_PHASE1","title":"Topical Minocycline for CARP","status":"NOT_YET_RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2026-06-01","conditions":"Confluent and Reticulated Papillomatosis (CARP)","enrollment":35},{"nctId":"NCT05367362","phase":"PHASE2","title":"Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke","status":"WITHDRAWN","sponsor":"State University of New York at Buffalo","startDate":"2025-12-01","conditions":"Acute Ischemic Stroke","enrollment":""},{"nctId":"NCT05902819","phase":"NA","title":"Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories","status":"COMPLETED","sponsor":"Psychiatric University Hospital, Zurich","startDate":"2023-05-10","conditions":"Post-traumatic Stress Disorder, Cocaine Use Disorder","enrollment":138},{"nctId":"NCT06246396","phase":"PHASE4","title":"Antihypertensive Mechanisms of Minocycline in Resistant Hypertension","status":"RECRUITING","sponsor":"University of Florida","startDate":"2025-01-08","conditions":"Hypertension, Resistant to Conventional Therapy","enrollment":120},{"nctId":"NCT06889701","phase":"PHASE1, PHASE2","title":"A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants","status":"RECRUITING","sponsor":"TenNor Therapeutics Inc.","startDate":"2025-04-03","conditions":"Periprosthetic Joint Infection (PJI)","enrollment":33},{"nctId":"NCT07437209","phase":"NA","title":"PRF + Minocycline vs Arestin in Non-surgical Perio Therapy","status":"COMPLETED","sponsor":"Center for Advanced Rejuvenation and Esthetics","startDate":"2024-12-01","conditions":"Non-surgical Periodontal Therapy","enrollment":15},{"nctId":"NCT07298057","phase":"EARLY_PHASE1","title":"Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics","status":"RECRUITING","sponsor":"Case Western Reserve University","startDate":"2026-02-06","conditions":"Periodontitis, Diabetes Mellitus Type 2","enrollment":42},{"nctId":"NCT05894954","phase":"PHASE3","title":"Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment","status":"COMPLETED","sponsor":"Alzheimer's Prevention and Reversal Project, Inc.","startDate":"2023-07-31","conditions":"Mild Cognitive Impairment, Dementia, Mild","enrollment":73},{"nctId":"NCT03489629","phase":"PHASE2","title":"STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2018-04-03","conditions":"Cystic Fibrosis","enrollment":37},{"nctId":"NCT07405684","phase":"PHASE4","title":"Fecal Molecular Susceptibility-guided Hp First-line Therapy","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-02-28","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":544},{"nctId":"NCT07405697","phase":"PHASE4","title":"Fecal Molecular Susceptibility-guided Hp Rescue Therapy","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-02-28","conditions":"Helicobacter Pylori Infection","enrollment":290},{"nctId":"NCT03106740","phase":"PHASE2","title":"Evaluating the Role of Neuroinflammation in Low Back Pain","status":"COMPLETED","sponsor":"Marco Loggia","startDate":"2017-10-10","conditions":"Low Back Pain, Back Pain With Radiation, Back Pain Without Radiation","enrollment":60},{"nctId":"NCT05074147","phase":"PHASE3","title":"Comparison Between Two Durations of Antibiotherapy for Non-surgically-treated Diabetic Foot Osteomyelitis (CHRONOS-2)","status":"WITHDRAWN","sponsor":"Tourcoing Hospital","startDate":"2022-05-01","conditions":"Osteomyelitis - Foot","enrollment":""},{"nctId":"NCT07338175","phase":"PHASE3","title":"Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-01","conditions":"Intracerebral Hemorrhage","enrollment":1192},{"nctId":"NCT06776445","phase":"PHASE1","title":"Efficacy and Safety of Different Dose Regimens of Gabapentin for Treating Erythema/Flushing in Rosacea: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2024-01-05","conditions":"Rosacea, Rosacea Subtype 1 (Erythematotelangiectatic)","enrollment":50},{"nctId":"NCT07305896","phase":"NA","title":"Efficacy and Safety of Minocycline in the Treatment of Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"The First Hospital of Jilin University","startDate":"2025-12-31","conditions":"Intracerebral Hemorrhage","enrollment":1248},{"nctId":"NCT05826912","phase":"PHASE2","title":"Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, San Francisco","startDate":"2024-08-01","conditions":"Traumatic Brain Injury","enrollment":672},{"nctId":"NCT06107725","phase":"PHASE2, PHASE3","title":"Maimonides Minocycline in Stroke Study","status":"TERMINATED","sponsor":"Maimonides Medical Center","startDate":"2023-11-01","conditions":"Stroke, Acute, Ischemic Stroke, Hemorrhagic Stroke","enrollment":2},{"nctId":"NCT05008731","phase":"PHASE3","title":"Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction","status":"ACTIVE_NOT_RECRUITING","sponsor":"GCS Ramsay Santé pour l'Enseignement et la Recherche","startDate":"2024-07-18","conditions":"Hamstring Contractures","enrollment":132},{"nctId":"NCT02564978","phase":"PHASE2","title":"Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2016-12-14","conditions":"Age-Related Macular Degeneration","enrollment":37},{"nctId":"NCT06201793","phase":"PHASE2","title":"Minocyclin in Ulcerative Colitis as Added on Therapy","status":"COMPLETED","sponsor":"Mostafa Bahaa","startDate":"2024-01-22","conditions":"Inflammatory Bowel Diseases","enrollment":46},{"nctId":"NCT06537921","phase":"NA","title":"Comorbid Obesity and Depression With an Anti-inflammatory Medication","status":"RECRUITING","sponsor":"King's College London","startDate":"2024-10-01","conditions":"Obesity, Major Depressive Disorder, Inflammation","enrollment":35},{"nctId":"NCT02133872","phase":"PHASE2","title":"Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients","status":"COMPLETED","sponsor":"University of Florida","startDate":"2014-10","conditions":"Hypertension","enrollment":34},{"nctId":"NCT06027151","phase":"NA","title":"Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients","status":"COMPLETED","sponsor":"Riphah International University","startDate":"2022-10-06","conditions":"Periodontitis, Diabetes Mellitus","enrollment":380},{"nctId":"NCT06033846","phase":"PHASE2","title":"Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis","status":"COMPLETED","sponsor":"Xijing Hospital","startDate":"2023-10-01","conditions":"Autoimmune Encephalitis","enrollment":60},{"nctId":"NCT07068607","phase":"PHASE4","title":"Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial","status":"RECRUITING","sponsor":"Yongquan Shi","startDate":"2025-04-01","conditions":"Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer","enrollment":400},{"nctId":"NCT03414502","phase":"PHASE3","title":"Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response","status":"RECRUITING","sponsor":"University of Nebraska","startDate":"2007-12-10","conditions":"Rheumatoid Arthritis","enrollment":400},{"nctId":"NCT06112938","phase":"","title":"Alternative Treatment Strategies for Stenotrophomonas Maltophilia Pneumonia","status":"COMPLETED","sponsor":"Methodist Health System","startDate":"2022-07-21","conditions":"Stenotrophomonas Maltophilia Infection","enrollment":110},{"nctId":"NCT07082855","phase":"PHASE3","title":"A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa","status":"NOT_YET_RECRUITING","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2025-07-15","conditions":"Retinitis Pigmentosa, Inherited Retinal Dystrophy, Retina Disorder","enrollment":126},{"nctId":"NCT05487417","phase":"PHASE4","title":"Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy","status":"RECRUITING","sponsor":"Xijing Hospital","startDate":"2022-11-01","conditions":"Ischemic Stroke, Acute","enrollment":180},{"nctId":"NCT06699966","phase":"PHASE4","title":"Stony Brook Medicine Anti-Inflammatory Trial","status":"NOT_YET_RECRUITING","sponsor":"Stony Brook University","startDate":"2026-01","conditions":"Major Depressive Disorder","enrollment":42},{"nctId":"NCT02113176","phase":"PHASE1, PHASE2","title":"Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage","status":"WITHDRAWN","sponsor":"University at Buffalo","startDate":"2010-01","conditions":"Subarachnoid Aneurysm Hemorrhage","enrollment":""},{"nctId":"NCT05422742","phase":"NA","title":"Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities","status":"ACTIVE_NOT_RECRUITING","sponsor":"West Virginia University","startDate":"2021-10-15","conditions":"Periodontitis","enrollment":50},{"nctId":"NCT06523764","phase":"PHASE4","title":"Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2024-11-11","conditions":"Helicobacter Pylori Infection Chronic Gastrit","enrollment":208},{"nctId":"NCT02213575","phase":"PHASE2","title":"Study 3: Minocycline Decreases Microglia Activation","status":"COMPLETED","sponsor":"University of Florida","startDate":"2016-03-05","conditions":"Hypertension","enrollment":5},{"nctId":"NCT05861258","phase":"PHASE2","title":"Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2023-05-08","conditions":"Mycobacterium Avium Complex Pulmonary Disease","enrollment":12},{"nctId":"NCT07012785","phase":"NA","title":"Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection","status":"NOT_YET_RECRUITING","sponsor":"Zhongda Hospital","startDate":"2025-06","conditions":"H. Pylori Infection","enrollment":208},{"nctId":"NCT06037590","phase":"PHASE1","title":"A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops® Relative to INBRIJA®","status":"COMPLETED","sponsor":"PureIMS B.V.","startDate":"2023-09-25","conditions":"Parkinson, Parkinson Disease, Parkinson's Disease and Parkinsonism","enrollment":26},{"nctId":"NCT05512910","phase":"PHASE4","title":"Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Xijing Hospital","startDate":"2023-03-04","conditions":"Ischemic Stroke, Acute, Minocycline, Endovascular Treatment","enrollment":90},{"nctId":"NCT06997731","phase":"PHASE1","title":"Clinical Efficacy of Local Delivery of Minocycline and Hyaluronan Gel to Treat Periodontitis in Diabetic Patients","status":"COMPLETED","sponsor":"Kafrelsheikh University","startDate":"2023-05-20","conditions":"Periodontitis and Diabetes, Periodontitis","enrollment":20},{"nctId":"NCT02719392","phase":"PHASE4","title":"A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression","status":"SUSPENDED","sponsor":"Massachusetts General Hospital","startDate":"2017-08-09","conditions":"Bipolar Disorder, Bipolar Depression","enrollment":40},{"nctId":"NCT05836740","phase":"PHASE3","title":"Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2023-05-19","conditions":"Ischemic Stroke, Acute","enrollment":1724},{"nctId":"NCT06892808","phase":"NA","title":"Impact of Periodontal Therapy on AF Recurrence Post-Ablation in High-Inflammatory Burden Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Xu Liu","startDate":"2025-03-05","conditions":"Atrial Fibrillation, Periodontitis","enrollment":212},{"nctId":"NCT06821763","phase":"PHASE2, PHASE3","title":"To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis","status":"NOT_YET_RECRUITING","sponsor":"Komal Ashraf Khan","startDate":"2025-05-01","conditions":"Apical Periodontitis, Irreversible Pulpitis with Apical Periodontitis","enrollment":180},{"nctId":"NCT06818578","phase":"PHASE4","title":"Success of Lesion Sterilization and Tissue Repair Therapy","status":"COMPLETED","sponsor":"Inonu University","startDate":"2022-09-14","conditions":"Primary Teeth, Pulp Necrosis, Pulpitis - Irreversible","enrollment":58},{"nctId":"NCT02515955","phase":"PHASE1","title":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54175446 in Healthy Male Participants","status":"COMPLETED","sponsor":"Janssen-Cilag International NV","startDate":"2015-08","conditions":"Healthy","enrollment":76},{"nctId":"NCT03762915","phase":"PHASE4","title":"Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2019-05-20","conditions":"SRP, Minocycline HCl Microspheres, Biomarkers","enrollment":70},{"nctId":"NCT02203552","phase":"PHASE2","title":"Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2015-06-23","conditions":"Anxiety Disorder, Depression, Recurrent Breast Cancer","enrollment":56},{"nctId":"NCT06332599","phase":"","title":"Minocycline for Helicobacter Pylori Rescue Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2021-03-01","conditions":"Helicobacter Pylori Infection","enrollment":823},{"nctId":"NCT06561698","phase":"PHASE4","title":"High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection","status":"RECRUITING","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2024-08-21","conditions":"Helicobacter Pylori Infection","enrollment":200},{"nctId":"NCT04531059","phase":"PHASE4","title":"Rescue Therapy for Helicobacter Pylori Eradication Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2020-10-15","conditions":"Helicobacter Pylori Infection","enrollment":368},{"nctId":"NCT06693362","phase":"PHASE1","title":"A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Uterine Blood Mesenchymal Stem Cells Injection for the Treatment of Severe Pneumonia Caused by Viruses","status":"RECRUITING","sponsor":"Ruijin Hospital","startDate":"2025-01-20","conditions":"Severe Viral Pneumonia(Not Include COVID-19)","enrollment":60},{"nctId":"NCT06044090","phase":"PHASE4","title":"Brain and Stress Study","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2022-09-12","conditions":"Stress, Psychological, Motivation","enrollment":10},{"nctId":"NCT05605366","phase":"PHASE1","title":"Minocycline in Neurocognitive Outcomes - Sickle Cell Disease","status":"NOT_YET_RECRUITING","sponsor":"University of Cincinnati","startDate":"2025-06-01","conditions":"Sickle Cell Disease, Cognitive Impairment, Cognitive Decline","enrollment":30},{"nctId":"NCT05644301","phase":"PHASE3","title":"INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder","status":"RECRUITING","sponsor":"Universiteit Antwerpen","startDate":"2023-09-21","conditions":"Major Depressive Disorder, Inflammation","enrollment":240},{"nctId":"NCT06603688","phase":"PHASE4","title":"Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.","status":"UNKNOWN","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2023-11-20","conditions":"Helicobacter Pylori Infection, Chronic Gastritis","enrollment":548},{"nctId":"NCT05032781","phase":"PHASE1","title":"Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention","status":"RECRUITING","sponsor":"Northwell Health","startDate":"2021-06-01","conditions":"Stroke, Ischemic","enrollment":24},{"nctId":"NCT01422148","phase":"PHASE2","title":"Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"Baystate Medical Center","startDate":"2025-07","conditions":"Atrial Fibrillation","enrollment":60},{"nctId":"NCT05499572","phase":"","title":"Usability of Levodopa Cyclops™ vs INBRIJA® in Parkinson's Patients","status":"COMPLETED","sponsor":"Martini Hospital Groningen","startDate":"2024-02-29","conditions":"Usability","enrollment":16},{"nctId":"NCT01283997","phase":"PHASE2","title":"Prevention of Treatment Induced Neuropathy in Multiple Myeloma","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2011-01-25","conditions":"Myeloma","enrollment":79},{"nctId":"NCT00720980","phase":"","title":"Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2008-05","conditions":"Granuloma Annulare","enrollment":6},{"nctId":"NCT05530252","phase":"PHASE4","title":"Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis","status":"COMPLETED","sponsor":"Beijing Stomatological Hospital, Capital Medical University","startDate":"2022-09-05","conditions":"Periodontitis","enrollment":51},{"nctId":"NCT02140164","phase":"PHASE1, PHASE2","title":"Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2014-05","conditions":"Retinitis Pigmentosa","enrollment":7},{"nctId":"NCT06307288","phase":"PHASE4","title":"Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea","status":"ENROLLING_BY_INVITATION","sponsor":"Second Affiliated Hospital of Xi'an Jiaotong University","startDate":"2023-10-16","conditions":"Rosacea","enrollment":45},{"nctId":"NCT06255067","phase":"PHASE2, PHASE3","title":"Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-02-25","conditions":"Periodontitis","enrollment":30},{"nctId":"NCT02133885","phase":"PHASE1, PHASE2","title":"Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients","status":"WITHDRAWN","sponsor":"University of Florida","startDate":"2023-01-30","conditions":"Hypertension","enrollment":""},{"nctId":"NCT04594733","phase":"PHASE1, PHASE2","title":"The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2021-12-06","conditions":"Fibromyalgia","enrollment":14},{"nctId":"NCT06207760","phase":"PHASE2","title":"Effect of Minocycline on Inflammation in Depressed Patients","status":"UNKNOWN","sponsor":"IRCCS Centro San Giovanni di Dio Fatebenefratelli","startDate":"2023-08-28","conditions":"Depression","enrollment":60},{"nctId":"NCT04068207","phase":"PHASE2","title":"Minocycline Treatment in Retinitis Pigmentosa","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2019-08-25","conditions":"Retinitis Pigmentosa, Inherited Retinal Dystrophy, Retina Disorder","enrollment":35},{"nctId":"NCT03320018","phase":"PHASE2, PHASE3","title":"Neuroprotection in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"Stony Brook University","startDate":"2017-08-02","conditions":"Stroke, Ischemic","enrollment":15},{"nctId":"NCT06174909","phase":"NA","title":"In Vivo Comparative Study of Calcium Hydroxide and Triple Antibiotic Paste in Intracanal Medicament in Emergency Pain Reduction","status":"COMPLETED","sponsor":"Pakistan Institute of Medical Sciences","startDate":"2022-11-01","conditions":"Pain","enrollment":90},{"nctId":"NCT02802631","phase":"PHASE1","title":"Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin (Minocycline) for Injection in Healthy Adults","status":"COMPLETED","sponsor":"Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)","startDate":"2017-04-20","conditions":"Normal Healthy Volunteers","enrollment":69},{"nctId":"NCT04210713","phase":"PHASE1","title":"Neuroimmune Dysfunction in Alcohol Use Disorder","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2020-02-03","conditions":"Alcohol Drinking, Alcohol-Related Disorders, Disease","enrollment":142},{"nctId":"NCT00579644","phase":"PHASE3","title":"Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2001-03-28","conditions":"Rheumatoid Arthritis","enrollment":91},{"nctId":"NCT04960930","phase":"PHASE3","title":"To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris","status":"COMPLETED","sponsor":"Cutia Therapeutics (Shanghai) Co., Ltd","startDate":"2021-09-17","conditions":"Acne Vulgaris","enrollment":372},{"nctId":"NCT01647282","phase":"PHASE4","title":"Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2012-10-01","conditions":"Moderate to Advanced Chronic Periodontitis","enrollment":60},{"nctId":"NCT03291158","phase":"PHASE1","title":"Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV","status":"WITHDRAWN","sponsor":"Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)","startDate":"2018-04","conditions":"Normal Healthy Volunteers","enrollment":""},{"nctId":"NCT01976065","phase":"PHASE1","title":"Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots","status":"COMPLETED","sponsor":"Kenneth Hargreaves","startDate":"2014-09","conditions":"Pulp Necrosis, Regeneration","enrollment":125},{"nctId":"NCT03160040","phase":"","title":"A Retrospective Observational Study to Evaluate the Utilization, Outcomes, and Adverse Events in Participants Treated With Minocin® (Minocycline) for Infections Caused by Gram-negative Bacteria in a Real World Setting","status":"COMPLETED","sponsor":"Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)","startDate":"2017-10-11","conditions":"Gram-Negative Bacterial Infections","enrollment":71},{"nctId":"NCT06004401","phase":"NA","title":"The Observation on the Efficacy of Dual Therapy Based on Vonoprazan in Eradicating Helicobacter Pylori","status":"UNKNOWN","sponsor":"Shanghai Changzheng Hospital","startDate":"2023-08-20","conditions":"The Eradication Rate of Helicobacter Pylori","enrollment":400},{"nctId":"NCT05597462","phase":"PHASE1","title":"Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks","status":"COMPLETED","sponsor":"Journey Medical Corporation","startDate":"2022-09-30","conditions":"Rosacea","enrollment":60},{"nctId":"NCT05958069","phase":"NA","title":"The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients","status":"UNKNOWN","sponsor":"Xijing Hospital","startDate":"2023-03-01","conditions":"Epileptic Seizures Related to Drugs","enrollment":25},{"nctId":"NCT04940767","phase":"PHASE4","title":"A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris","status":"COMPLETED","sponsor":"Edward Lain, MD","startDate":"2021-06-28","conditions":"Acne Vulgaris","enrollment":31},{"nctId":"NCT05474950","phase":"PHASE1, PHASE2","title":"Minocycline Treatment for Cystoid Macular Edema","status":"UNKNOWN","sponsor":"Sun Yat-sen University","startDate":"2019-01-01","conditions":"Minocycline, Cystoid Macular Edema","enrollment":5},{"nctId":"NCT01531582","phase":"NA","title":"Minocycline in the Treatment of Angelman Syndrome","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2012-04","conditions":"Angelman Syndrome","enrollment":25},{"nctId":"NCT05474729","phase":"PHASE1, PHASE2","title":"Minocycline for Chronic Autoimmune Uveitis","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2021-12-01","conditions":"Minocycline, Uveitis, Retinal Degeneration","enrollment":10},{"nctId":"NCT05500157","phase":"NA","title":"Assessment of Treatment With Laparoscopic Fenestration or Aspiration Sclerotherapy for Large Symptomatic Hepatic Cysts","status":"UNKNOWN","sponsor":"Radboud University Medical Center","startDate":"2022-10-01","conditions":"Liver Cyst, Polycystic Liver Disease, Autosomal Dominant Polycystic Kidney","enrollment":70},{"nctId":"NCT04291456","phase":"PHASE3","title":"Minocycline in MS: Confirmation of Benefit","status":"TERMINATED","sponsor":"University of Calgary","startDate":"2020-01-31","conditions":"Multiple Sclerosis, Clinically Isolated Syndrome","enrollment":9},{"nctId":"NCT05452785","phase":"PHASE1","title":"A Comparative Bioavailability Study of DFD-29 Capsules 40 mg Versus SOLODYN® Tablets 105 mg, Under Fasting & Fed Conditions in Healthy Adult Human Subjects","status":"COMPLETED","sponsor":"Journey Medical Corporation","startDate":"2022-05-07","conditions":"Pharmacokinetics","enrollment":24},{"nctId":"NCT04923113","phase":"NA","title":"Comparison of Different Helicobacter Pylori Detection Methods in Patients With Chronic Atrophic Gastritis","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2021-06-28","conditions":"Helicobacter Pylori Infection","enrollment":281},{"nctId":"NCT04876638","phase":"PHASE2","title":"Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Southern California","startDate":"2019-07-01","conditions":"Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia","enrollment":20},{"nctId":"NCT05301686","phase":"","title":"Is There a Correlation Between Surgical Technique for Primary Anterior Cruciate Ligament Surgery and the Risk of Subsequent Formation of Fibrous Cyst (Cyclops) in the Knee Joint, Which Leads to the Need for Surgical Removal of the Cyclops?","status":"COMPLETED","sponsor":"Aarhus University Hospital","startDate":"2021-10-01","conditions":"Cyclop Arthrofibrosis Anterior Cruciate Ligament","enrollment":2556},{"nctId":"NCT05586815","phase":"PHASE4","title":"Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2023-01-10","conditions":"Acinetobacter Infections","enrollment":94},{"nctId":"NCT05681221","phase":"NA","title":"Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-02-20","conditions":"Root Canal Infection","enrollment":22},{"nctId":"NCT05680389","phase":"PHASE1, PHASE2","title":"Antibiotics Against Amyloid Angiopathy","status":"UNKNOWN","sponsor":"Leiden University Medical Center","startDate":"2020-12-02","conditions":"Cerebral Amyloid Angiopathy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":88,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"active","brandName":"Minocyclin","genericName":"Minocyclin","companyName":"University of Southern California","companyId":"university-of-southern-california","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":false,"indications":true,"safety":true,"trials":true,"score":3}}