{"id":"mino-lok","safety":{"commonSideEffects":[{"rate":null,"effect":"Local catheter site reactions"},{"rate":null,"effect":"Thrombosis"},{"rate":null,"effect":"Catheter dysfunction"}]},"_chembl":{"chemblId":"CHEMBL578482","moleculeType":"Small molecule","molecularWeight":"666.82"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mino-Lok combines minocycline and edetic acid (EDTA) to create a catheter lock solution that inhibits bacterial adhesion and biofilm development on the internal surfaces of central venous catheters. The formulation is designed to be instilled into the catheter lumen between uses to prevent catheter-related bloodstream infections (CRBSIs) in patients requiring long-term venous access.","oneSentence":"Mino-Lok is a antimicrobial lock solution that prevents biofilm formation and reduces bacterial colonization on central venous catheters.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:21:30.898Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of catheter-related bloodstream infections (CRBSIs) in patients with central venous catheters"}]},"trialDetails":[{"nctId":"NCT02901717","phase":"PHASE3","title":"Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI","status":"UNKNOWN","sponsor":"Leonard-Meron Biosciences, Inc.","startDate":"2018-02-13","conditions":"Catheter-related Infections","enrollment":144},{"nctId":"NCT04513821","phase":"","title":"Expanded Access: Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI","status":"AVAILABLE","sponsor":"Leonard-Meron Biosciences, Inc.","startDate":"","conditions":"Catheter-Related Infections","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Standard of care antibiotics + Mino-Lok"],"phase":"phase_3","status":"active","brandName":"Mino-Lok","genericName":"Mino-Lok","companyName":"Leonard-Meron Biosciences, Inc.","companyId":"leonard-meron-biosciences-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mino-Lok is a antimicrobial lock solution that prevents biofilm formation and reduces bacterial colonization on central venous catheters. Used for Prevention of catheter-related bloodstream infections (CRBSIs) in patients with central venous catheters.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}