{"id":"mimosine","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Tyrosinase","category":"target"},{"label":"TYR","category":"gene"},{"label":"DOHH","category":"gene"},{"label":"SHMT1","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mimosin","offLabel":[],"synonyms":["mimosine","L-Mimosine","leucaenine","leucaenol","leucenine","leucenol","mimosin"],"timeline":[],"approvals":[],"brandName":"Mimosin","ecosystem":[],"mechanism":{"target":"Deoxyhypusine hydroxylase, Serine hydroxymethyltransferase, cytosolic, Tyrosinase","targets":[{"gene":"TYR","source":"DrugCentral","target":"Tyrosinase","protein":"Tyrosinase"},{"gene":"DOHH","source":"DrugCentral","target":"Deoxyhypusine hydroxylase","protein":"Deoxyhypusine hydroxylase"},{"gene":"SHMT1","source":"DrugCentral","target":"Serine hydroxymethyltransferase, cytosolic","protein":"Serine hydroxymethyltransferase, cytosolic"}],"modality":"Small Molecule","explanation":"Think of melanin like a pigment that gives color to your skin, hair, and eyes. Tyrosinase is the enzyme that helps turn the amino acid tyrosine into melanin. Mimosin blocks this process, which could potentially affect how much melanin is produced in the body.","oneSentence":"Mimosin works by inhibiting the enzyme tyrosinase, which is involved in the production of melanin from the amino acid tyrosine.","technicalDetail":"Mimosin acts as a competitive inhibitor of tyrosinase, specifically binding to the copper ion at the active site of the enzyme and preventing the oxidation of tyrosine to dopachrome, thereby inhibiting melanin production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1811","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mimosine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:45:45.394192","biosimilars":[],"competitors":[{"drugName":"pemetrexed","drugSlug":"pemetrexed","fdaApproval":"2004-02-04","patentExpiry":"Oct 28, 2035","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"pyridoxine","drugSlug":"pyridoxine","fdaApproval":"1993-12-29","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"mimosine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"pemetrexed","brandName":"pemetrexed","genericName":"pemetrexed","approvalYear":"2004","relationship":"same-target"},{"drugId":"pyridoxine","brandName":"pyridoxine","genericName":"pyridoxine","approvalYear":"1993","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"Z46B1LUI5N","CHEBI":"CHEBI:29063","UMLSCUI":"C0026153","ChEMBL_ID":"CHEMBL251433","DRUGBANK_ID":"DB01055","PDB_CHEM_ID":" MMS","PUBCHEM_CID":"3862","SNOMEDCT_US":"87931005","MESH_DESCRIPTOR_UI":"D008898"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":538,"therapeuticAreas":["Ophthalmology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Mimosine is a toxic non-protein amino acid that occurs in some Mimosa species and all members of the related genus Leucaena, chemically similar to tyrosine. It is a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}