{"id":"migranal-nasal-spray-at-1-hour","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal congestion or irritation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vasoconstriction-related symptoms"},{"rate":null,"effect":"Taste disturbance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroergotamine is an ergot alkaloid derivative that acts as a non-selective serotonin receptor agonist, particularly at 5-HT1B and 5-HT1D receptors on cranial blood vessels and nerve terminals. This causes vasoconstriction of dilated cerebral blood vessels and inhibits the release of vasoactive neuropeptides involved in migraine pathophysiology. The nasal spray formulation provides rapid systemic absorption for acute migraine relief.","oneSentence":"Migranal (dihydroergotamine) is a vasoconstrictor that binds to serotonin receptors to relieve migraine headaches by narrowing blood vessels around the brain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:19.780Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine headache with or without aura"},{"name":"Cluster headache"}]},"trialDetails":[{"nctId":"NCT00335777","phase":"PHASE4","title":"A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2006-08","conditions":"Migraine","enrollment":64}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dihydroergotamine (DHE)"],"phase":"marketed","status":"active","brandName":"Migranal nasal spray at 1 hour","genericName":"Migranal nasal spray at 1 hour","companyName":"Thomas Jefferson University","companyId":"thomas-jefferson-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Migranal (dihydroergotamine) is a vasoconstrictor that binds to serotonin receptors to relieve migraine headaches by narrowing blood vessels around the brain. Used for Acute migraine headache with or without aura, Cluster headache.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}