{"id":"mifepristone-tablets","safety":{"commonSideEffects":[{"rate":"95","effect":"Vaginal bleeding/hemorrhage"},{"rate":"85","effect":"Abdominal pain/cramping"},{"rate":"50","effect":"Nausea"},{"rate":"25","effect":"Vomiting"},{"rate":"20","effect":"Diarrhea"},{"rate":"10","effect":"Dizziness"},{"rate":"10","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mifepristone competitively binds to progesterone receptors in the uterus and other tissues, blocking the effects of endogenous progesterone. This leads to endometrial breakdown and detachment of the conceptus, resulting in pregnancy termination when used in the early stages of pregnancy. It is typically used in combination with a prostaglandin analog (such as misoprostol) to enhance efficacy.","oneSentence":"Mifepristone is a progesterone receptor antagonist that blocks progesterone signaling, preventing pregnancy establishment and maintenance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:23.316Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Medical termination of intrauterine pregnancy of up to 49 days gestation (in combination with misoprostol)"}]},"trialDetails":[{"nctId":"NCT06099769","phase":"PHASE2","title":"A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2023-10-18","conditions":"Metastatic Breast Cancer","enrollment":201},{"nctId":"NCT07422506","phase":"NA","title":"A Real-World Study Comparing the Efficacy of Different Treatment Regimens for 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Used for Medical termination of intrauterine pregnancy of up to 49 days gestation (in combination with misoprostol).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}