{"id":"mifepristone-misoprostol","safety":{"commonSideEffects":[{"rate":"~100","effect":"Vaginal bleeding"},{"rate":"~90","effect":"Abdominal pain/cramping"},{"rate":"~50","effect":"Nausea"},{"rate":"~25","effect":"Vomiting"},{"rate":"~20","effect":"Diarrhea"},{"rate":"~10","effect":"Headache"},{"rate":"~10","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mifepristone is a selective progesterone receptor antagonist that prevents progesterone from maintaining the uterine lining and pregnancy. Misoprostol is a prostaglandin analog that induces uterine contractions and cervical dilation, facilitating expulsion of pregnancy tissue. Together, they provide a medical abortion regimen effective through the first 10 weeks of gestation.","oneSentence":"Mifepristone blocks progesterone receptors to stop pregnancy maintenance, while misoprostol induces uterine contractions to expel the pregnancy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:13.270Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Medical abortion up to 10 weeks of gestation"}]},"trialDetails":[{"nctId":"NCT05322252","phase":"PHASE4","title":"Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2022-07-01","conditions":"Abortion, Second Trimester, PPROM, Rupture, Spontaneous","enrollment":30},{"nctId":"NCT07422506","phase":"NA","title":"A Real-World Study Comparing the Efficacy of Different Treatment 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Edward Memorial Hospital","startDate":"2009-04","conditions":"Pregnancy","enrollment":302},{"nctId":"NCT00680394","phase":"NA","title":"Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2007-07","conditions":"Pregnancy Termination","enrollment":440},{"nctId":"NCT01410266","phase":"PHASE4","title":"Reducing the Need for In-Clinic Follow-Up for Medical Abortion in Moldova and Uzbekistan","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2010-09","conditions":"Medical Abortion, Fetus","enrollment":2400},{"nctId":"NCT00997347","phase":"PHASE4","title":"The Extended Gestational Age Medical Abortion Study","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2009-07","conditions":"Medical Abortion","enrollment":1400},{"nctId":"NCT00997074","phase":"PHASE3","title":"Efficacy Study of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion","status":"COMPLETED","sponsor":"Sheba Medical Center","startDate":"2009-10","conditions":"Pain, Pregnancy","enrollment":61},{"nctId":"NCT01475318","phase":"NA","title":"Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2011-10","conditions":"Complete Abortion","enrollment":50},{"nctId":"NCT00957346","phase":"PHASE3","title":"Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14-21 Weeks LMP)","status":"TERMINATED","sponsor":"Gynuity Health Projects","startDate":"2011-02","conditions":"Abortion, Induced","enrollment":20},{"nctId":"NCT01156688","phase":"PHASE4","title":"A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation","status":"COMPLETED","sponsor":"The University of Hong 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