{"id":"midcab","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding/transfusion requirement"},{"rate":null,"effect":"Arrhythmia"},{"rate":null,"effect":"Myocardial infarction"},{"rate":null,"effect":"Stroke"},{"rate":null,"effect":"Graft failure"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:48:38.693479","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"MIDCAB (Minimally Invasive Direct Coronary Artery Bypass) is a surgical procedure rather than a pharmacological drug. It involves grafting a vessel (typically the internal mammary artery) to bypass a blocked coronary artery through a small left anterior thoracotomy incision, avoiding the need for full median sternotomy and cardiopulmonary bypass in selected cases. This approach reduces surgical trauma, recovery time, and postoperative morbidity compared to conventional open-heart bypass surgery.","oneSentence":"MIDCAB is a minimally invasive surgical technique for coronary artery bypass grafting that uses a small thoracotomy incision instead of full sternotomy to access and graft coronary arteries.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:16.347Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Coronary artery disease amenable to bypass grafting via minimally invasive approach"},{"name":"Left anterior descending (LAD) coronary artery stenosis"}]},"_fixedFields":["pubmed(540)"],"trialDetails":[{"nctId":"NCT06584981","phase":"NA","title":"Effect of PECS II, Parasternal and Serratus Plane Blocks on Postoperative Pain in MIDCAB Surgery","status":"COMPLETED","sponsor":"Hisar Intercontinental Hospital","startDate":"2024-09-01","conditions":"Pain, Postoperative, Coronary Artery Disease","enrollment":88},{"nctId":"NCT05368012","phase":"PHASE4","title":"MIDCAB (Mid-Calf Block) for Foot Surgery","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2022-07-21","conditions":"Ankle Surgery, Foot Surgery","enrollment":20},{"nctId":"NCT06378775","phase":"NA","title":"Robotically-assisted Minimally-invasive Direct Coronary Artery Bypass With Stenting, Randomized Against Coronary Artery Bypass Graft Surgery","status":"NOT_YET_RECRUITING","sponsor":"Cardiology Research UBC","startDate":"2024-05-01","conditions":"Coronary Artery Disease, Multivessel Coronary Artery Disease","enrollment":80},{"nctId":"NCT05504031","phase":"NA","title":"Hybrid Revascularization Versus Coronary Artery Bypass Grafting","status":"NOT_YET_RECRUITING","sponsor":"Rigshospitalet, Denmark","startDate":"2025-01","conditions":"Coronary Artery Disease","enrollment":1048},{"nctId":"NCT04698460","phase":"NA","title":"FUNctional eFficacy of Hybrid coronAry REvascularization","status":"TERMINATED","sponsor":"Tomsk National Research Medical Center of the Russian Academy of Sciences","startDate":"2021-01-15","conditions":"Coronary Artery Disease","enrollment":13},{"nctId":"NCT04982016","phase":"NA","title":"Effects of Fluid Therapy on Microcirculatory Reactivity","status":"UNKNOWN","sponsor":"Beijing Anzhen Hospital","startDate":"2021-09","conditions":"Microcirculation, Fluid Therapy","enrollment":126},{"nctId":"NCT04811586","phase":"NA","title":"Efficacy and Safety of One-Stage Hybrid Coronary Revascularization","status":"UNKNOWN","sponsor":"Shanghai East Hospital","startDate":"2020-12-30","conditions":"Multivessel Coronary Artery Disease","enrollment":200},{"nctId":"NCT04267835","phase":"","title":"Prospective Cohort Study on Minimal Invasive Coronary Surgery","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2020-04-04","conditions":"Coronary Artery Bypass, Off-Pump","enrollment":400},{"nctId":"NCT00299429","phase":"NA","title":"MIDCAB Versus DES in Proximal LAD Lesions","status":"COMPLETED","sponsor":"University of Leipzig","startDate":"2003-01","conditions":"Coronary Artery Disease","enrollment":130},{"nctId":"NCT03110120","phase":"NA","title":"Interest of Serratus Plane Block in Postoperative Analgesia for Robot-assisted Surgery","status":"COMPLETED","sponsor":"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","startDate":"2015-05","conditions":"Analgesia, Robotic Surgery","enrollment":60},{"nctId":"NCT01699048","phase":"NA","title":"The Comparative Effectiveness of Hybrid Revascularization (MIDCAB Then PCI) With DES Versus Multivessel DES PCI or CABG","status":"COMPLETED","sponsor":"Russian Academy of Medical Sciences","startDate":"2012-12-01","conditions":"Coronary Artery Disease, Myocardial Ischemia, Coronary Disease","enrollment":150},{"nctId":"NCT01443754","phase":"","title":"Hybrid Revascularisation by Combined Coronary Artery Bypass Graft (CABG) and PCI in Multivessel Coronary Disease","status":"TERMINATED","sponsor":"Ettore Sansavini Health Science Foundation","startDate":"2011-09","conditions":"Coronary Artery Disease (CAD)","enrollment":50},{"nctId":"NCT01035567","phase":"PHASE2, PHASE3","title":"Safety and Efficacy Study of Hybrid Revascularization in Multivessel Coronary Artery Disease","status":"COMPLETED","sponsor":"Silesian Centre for Heart Diseases","startDate":"2009-11","conditions":"Heart Disease, Myocardial Ischaemia, Coronary Disease","enrollment":200},{"nctId":"NCT01034371","phase":"NA","title":"Comparison of One-stop Hybrid Revascularization Versus Off-pump Coronary Artery Bypass for the Treatment of Multi-vessel Disease","status":"UNKNOWN","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2009-12","conditions":"Coronary Artery Disease","enrollment":400},{"nctId":"NCT01035034","phase":"NA","title":"Comparison of One-stop Hybrid Revascularization Versus Percutaneous Coronary Intervention for the Treatment of Multi-vessel Disease","status":"UNKNOWN","sponsor":"China National Center for Cardiovascular Diseases","startDate":"2009-12","conditions":"Coronary Artery Disease","enrollment":480}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":540,"recentPublications":[{"date":"2026 Feb 28","pmid":"41827279","title":"Revascularization of Left Anterior Descending Artery with Minimally Invasive Direct Coronary Artery Bypass Graft vs. Drug Eluting Stents: A Retrospective, Two-Center Study.","journal":"Journal of clinical medicine"},{"date":"2025 Sep 30","pmid":"41805485","title":"[Perioperative results of minimally invasive direct artery bypass grafting (MIDCAB) in treatment of patients with ischemic heart disease: 1366 operated patients].","journal":"Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery"},{"date":"2026 Jan","pmid":"41755980","title":"Minimally Invasive Coronary Artery Revascularization Surgery Versus Conventional Techniques in Patients With Complex Coronary Artery Disease: A Systematic Review of Cardiac Function.","journal":"Cureus"},{"date":"2026 Feb 24","pmid":"41734056","title":"Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course.","journal":"Clinical chemistry"},{"date":"2026 Feb 17","pmid":"41703604","title":"Surgical outcomes of EA-MIDCAB vs. full sternotomy CABG in multi-vessel coronary artery disease: a retrospective cohort study.","journal":"Journal of cardiothoracic surgery"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bupivacaine and dexamethasone"],"phase":"marketed","status":"active","brandName":"MIDCAB","genericName":"MIDCAB","companyName":"Hospital for Special Surgery, New York","companyId":"hospital-for-special-surgery-new-york","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MIDCAB is a minimally invasive surgical technique for coronary artery bypass grafting that uses a small thoracotomy incision instead of full sternotomy to access and graft coronary arteries. Used for Coronary artery disease amenable to bypass grafting via minimally invasive approach, Left anterior descending (LAD) coronary artery stenosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}