{"id":"microplegic-solution-no-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Myocardial ischemic injury"},{"rate":null,"effect":"Arrhythmias post-operatively"},{"rate":null,"effect":"Electrolyte imbalances"}]},"_chembl":{"chemblId":"CHEMBL2108251","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This solution works by rapidly depolarizing cardiac myocytes through high potassium concentration, inducing asystole (cardiac arrest) that reduces myocardial oxygen demand. The formulation typically contains electrolytes, buffers, and sometimes additives designed to preserve myocardial function and minimize ischemic injury during the period of surgical manipulation when the heart is not perfused.","oneSentence":"Microplegic Solution No. 1 is a cardioplegic solution used to induce controlled cardiac arrest and protect the heart during cardiac surgery.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:55:08.474Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Myocardial protection during cardiac surgery requiring cardiopulmonary bypass"}]},"trialDetails":[{"nctId":"NCT05076604","phase":"PHASE4","title":"Effects of Microplegia on Transfusion Rates After Cardiac Surgery","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-03-25","conditions":"Aortic Valve Disease, Mitral Valve Disease","enrollment":314}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":118,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Microplegic Solution No. 1","genericName":"Microplegic Solution No. 1","companyName":"Washington University School of Medicine","companyId":"washington-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Microplegic Solution No. 1 is a cardioplegic solution used to induce controlled cardiac arrest and protect the heart during cardiac surgery. Used for Myocardial protection during cardiac surgery requiring cardiopulmonary bypass.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}