{"id":"microplasmin","rwe":[],"tags":[],"phase":"discontinued","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"discontinued","trials":["NCT04879615","NCT03172052","NCT00798317","NCT01878136","NCT01492725","NCT02347358","NCT00000507","NCT02492477","NCT03661411","NCT03854500","NCT05141305","NCT07466524","NCT05395338","NCT06194968","NCT04505592","NCT02035748","NCT01089140","NCT04240470","NCT03989505","NCT02191670","NCT06070350","NCT06583889","NCT00396032","NCT03851965","NCT02850692","NCT00790335","NCT04174989","NCT01835067","NCT02326428","NCT04088292","NCT07003646","NCT04526951","NCT03452722","NCT04915586","NCT06980506","NCT01204333","NCT00303420","NCT02309970","NCT03678090","NCT00265005","NCT05233501","NCT03278275","NCT02398656","NCT00250991","NCT03988842","NCT02315898","NCT06797999","NCT06571149","NCT00395876","NCT01472926"],"aliases":[],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"aiSummary":"","brandName":"Microplasmin","companyId":"university-of-california-los-angeles","ecosystem":[],"mechanism":{"target":"","novelty":"","modality":"Small molecule","drugClass":"","explanation":"","oneSentence":"","technicalDetail":""},"commercial":null,"references":[],"biosimilars":[],"companyName":"University of California, Los Angeles","competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"Microplasmin","indications":{"approved":[{"name":"Vitreomacular traction syndrome","diseaseId":"vitreomacular-traction-syndrome","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT04879615","phase":"Phase 3","title":"Treatment with Intravenous Alteplase in Ischemic Stroke Patients with Onset Time Between 4.5 and 24 Hours","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","isPivotal":true,"enrollment":372,"indication":"Stroke","completionDate":"2024-09-30"},{"nctId":"NCT03172052","phase":"Phase 4","title":"Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital","status":"UNKNOWN","sponsor":"Assiut University","isPivotal":false,"enrollment":100,"indication":"Pleural Effusion","completionDate":"2020-06-30"},{"nctId":"NCT00798317","phase":"Phase 3","title":"A Randomized, Placebo Controlled, Double-masked, Multicenter Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion.","status":"COMPLETED","sponsor":"ThromboGenics","isPivotal":true,"enrollment":326,"indication":"Vitreomacular Adhesion","completionDate":"2010-07"},{"nctId":"NCT01878136","phase":"Phase 1","title":"Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage","status":"WITHDRAWN","sponsor":"Rush University Medical Center","isPivotal":false,"enrollment":0,"indication":"Subarachnoid Hemorrhage, Cerebral Vasospasm","completionDate":"2016-09"},{"nctId":"NCT01492725","phase":"Phase 2","title":"A Randomized Controlled Trial of Intra-arterial Reperfusion Therapy After Standard Dose Intravenous t-PA Within 4.5 Hours of Stroke Onset Utilizing Dual Target Imaging Selection.","status":"TERMINATED","sponsor":"Neuroscience Trials Australia","isPivotal":false,"enrollment":70,"indication":"Ischemic Stroke","completionDate":"2014-12"},{"nctId":"NCT02347358","phase":"Phase 2","title":"Mechanical Opening Device Implantation Following Intravenous r-tPA and Recanalization Outcome Evaluation in Stroke Disease (MODIFIED) Trial","status":"UNKNOWN","sponsor":"The Second Artillery General Hospital","isPivotal":false,"enrollment":100,"indication":"Ischemic Cerebrovascular Accident","completionDate":"2017-04"},{"nctId":"NCT00000507","phase":"Phase 3","title":"","status":"COMPLETED","sponsor":"University of Washington","isPivotal":true,"enrollment":0,"indication":"Cardiovascular Diseases, Coronary Disease","completionDate":"1994-10"},{"nctId":"NCT02492477","phase":"Phase 1","title":"TOP-TRIAL The Safety of Not Flushing the Non-used PORT-A-CATH® in Cancer Patients - a Prospective, Two-arm Phase I Trial, Pilot Trial","status":"TERMINATED","sponsor":"Krankenhaus Barmherzige Schwestern Linz","isPivotal":false,"enrollment":4,"indication":"Adjuvant Chemotherapy, Solid Tumours","completionDate":"2016-07"},{"nctId":"NCT03661411","phase":"Phase 4","title":"Antiplatelet vs R-tPA for Acute Mild Ischemic Stroke: a Prospective, Random, Blinded Assessment of Outcome and Open Label Multi-center Study","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","isPivotal":false,"enrollment":760,"indication":"Stroke","completionDate":"2022-07-18"},{"nctId":"NCT03854500","phase":"Phase 3","title":"A Randomised Trial of Tenecteplase vs. Alteplase in Acute Ischemic Stroke","status":"TERMINATED","sponsor":"Haukeland University Hospital","isPivotal":true,"enrollment":201,"indication":"Stroke, Acute, Cerebrovascular Disorders","completionDate":"2021-12-31"},{"nctId":"NCT05141305","phase":"Phase 3","title":"A Phase 3, Multicenter, Prospective, Randomized, Open-label, Blinded-endpoint (PROBE) Controlled Trial of Tenecteplase Versus Standard Medical Treatment for Acute Ischemic Stroke Due to Anterior Circu","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","isPivotal":true,"enrollment":516,"indication":"Ischemic Stroke, Acute","completionDate":"2024-02-09"},{"nctId":"NCT07466524","phase":"N/A","title":"suPAR ≥6 ng/mL for Predicting Severe Respiratory Failure in U.S. Adults Hospitalized With COVID 19 (suPAR US The Michigan Cohort Heterogeneity Study)","status":"COMPLETED","sponsor":"ViroGates A/S","isPivotal":false,"enrollment":367,"indication":"COVID-19, Severe Respiratory Distress Syndrome","completionDate":"2022-10-19"},{"nctId":"NCT05395338","phase":"N/A","title":"1-year Clinical Outcomes After Intravenous Rt-PA for Chinese AIS Patients","status":"COMPLETED","sponsor":"Boehringer Ingelheim","isPivotal":false,"enrollment":12551,"indication":"Stroke","completionDate":"2022-11-30"},{"nctId":"NCT06194968","phase":"N/A","title":"Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study (TASK-UK)","status":"RECRUITING","sponsor":"The First Affiliated Hospital of Zhengzhou University","isPivotal":false,"enrollment":1800,"indication":"Acute Ischemic Stroke","completionDate":"2026-12-01"},{"nctId":"NCT04505592","phase":"Phase 2","title":"Tenecteplase With Concomitant Anticoagulation for Severe Acute Respiratory Failure in Patients With COVID-19","status":"COMPLETED","sponsor":"Hooman Poor","isPivotal":false,"enrollment":13,"indication":"COVID-19, Respiratory Failure","completionDate":"2022-03-10"},{"nctId":"NCT02035748","phase":"Phase 4","title":"Assessment of Anatomical and Functional Outcomes in Patients Treated With Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion (VMT/sVMA)","status":"COMPLETED","sponsor":"Alcon Research","isPivotal":false,"enrollment":628,"indication":"Vitreomacular Traction, Vitreomacular Adhesion","completionDate":"2015-09"},{"nctId":"NCT01089140","phase":"Phase 2","title":"Blood Loss and Transfusion Requirement in Pediatric Patients With Non-Idiopathic Scoliosis Treated With Tranexamic Acid Undergoing Posterior Spinal Instrumentation and Fusion.","status":"TERMINATED","sponsor":"The Hospital for Sick Children","isPivotal":false,"enrollment":2,"indication":"Non-idiopathic Scoliosis","completionDate":"2014-11"},{"nctId":"NCT04240470","phase":"NA","title":"Endovascular Stroke Treatment Only (ESTO) Trial","status":"COMPLETED","sponsor":"University of Missouri-Columbia","isPivotal":false,"enrollment":72,"indication":"Acute Ischemic Stroke","completionDate":"2021-10-23"},{"nctId":"NCT03989505","phase":"N/A","title":"Proenkephalin ANd Creatinine in the Prediction of Cardiac Contrast-Associated Kidney Events","status":"COMPLETED","sponsor":"Dr. med. Mahir Karakas","isPivotal":false,"enrollment":220,"indication":"Contrast-induced Nephropathy, Acute Kidney Injury","completionDate":"2021-12-31"},{"nctId":"NCT02191670","phase":"N/A","title":"A Post-registration, Open Label Therapeutic Observational Study of METALYSE® in Patients With Acute Myocardial Infarction In Russian Federation.","status":"COMPLETED","sponsor":"Boehringer Ingelheim","isPivotal":false,"enrollment":60,"indication":"Myocardial Infarction","completionDate":""},{"nctId":"NCT06070350","phase":"Phase 3","title":"Massive Transfusion in Children: a Platform RCT of Whole Blood Compared to Component Therapy and Tranexamic Acid to Placebo in Life-threatening Traumatic Bleeding","status":"RECRUITING","sponsor":"Philip Spinella","isPivotal":true,"enrollment":1000,"indication":"Hemorrhagic Shock, Trauma Injury","completionDate":"2028-10-01"},{"nctId":"NCT06583889","phase":"NA","title":"Efficacy and Safety of endovasCular Treatment vs Standard Medical Care for Cerebral venOus Sinus thRombosis With mulTimodal Imaging Selection(ESCORT)","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","isPivotal":false,"enrollment":224,"indication":"Cerebral Venous Sinus Thrombosis","completionDate":"2029-08"},{"nctId":"NCT00396032","phase":"Phase 3","title":"A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Restoration of Function in Dysfunctional Hemodialysis Catheters","status":"COMPLETED","sponsor":"Genentech, Inc.","isPivotal":true,"enrollment":150,"indication":"Dysfunctional Hemodialysis Catheters","completionDate":""},{"nctId":"NCT03851965","phase":"N/A","title":"A Prospective Observational Study on Assessment of the Soluble Urokinase Plasminogen Activator Receptor in Adult Patients Undergoing Major Non-cardiac Surgery","status":"COMPLETED","sponsor":"University of Thessaly","isPivotal":false,"enrollment":100,"indication":"Surgery--Complications","completionDate":"2020-11-05"},{"nctId":"NCT02850692","phase":"NA","title":"Portal Hypertension and Systemic Endothelial Function: Investigation of Systemic Endothelial Dysfunction in Case of Portal Hypertension Associated With Cystic Fibrosis.","status":"UNKNOWN","sponsor":"Hopital Foch","isPivotal":false,"enrollment":60,"indication":"Cystic Fibrosis, Portal Hypertension","completionDate":"2021-12"},{"nctId":"NCT00790335","phase":"Phase 3","title":"Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis--The ATTRACT Trial","status":"COMPLETED","sponsor":"Washington University School of Medicine","isPivotal":true,"enrollment":692,"indication":"Deep Vein Thrombosis, Venous Thrombosis","completionDate":"2017-01"},{"nctId":"NCT04174989","phase":"NA","title":"MULTI-CENTER,DOUBLE-BLIND, RANDOMIZED, TWO-ARMS, CONTROLLED, PROSPECTIVE CLINICAL INVESTIGATION ASSESSING THE SAFETY AND PERFORMANCE OF A CLASS IIb MEDICAL DEVICE (CLEARPLASMATM) FOR THE TREATMENT OF ","status":"COMPLETED","sponsor":"PlasFree Ltd.","isPivotal":false,"enrollment":53,"indication":"Acute Upper Gastrointestinal Hemorrhage, Acute Upper Gastrointestinal Bleeding","completionDate":"2022-11-13"},{"nctId":"NCT01835067","phase":"Phase 2","title":"Intravitreal Tissue Plasminogen Activator And Perfluoropropane for Neovascular Age-related Macular Degeneration With Associated Submacular Haemorrhage: a Multi-centre, Randomized, Double-masked, Sham-","status":"COMPLETED","sponsor":"King's College Hospital NHS Trust","isPivotal":true,"enrollment":55,"indication":"Exudative Macular Degeneration, Retinal Hemorrhage","completionDate":"2019-12"},{"nctId":"NCT02326428","phase":"NA","title":"An Open, Prospective, Blinded Evaluation, International, Multicentre, Controlled Study of Safety and Efficacy of Thrombectomy and Standard Stroke Care in Clinical Routine Treatment of Acute Occlusive ","status":"COMPLETED","sponsor":"Karolinska Institutet","isPivotal":false,"enrollment":341,"indication":"Ischemic Stroke","completionDate":"2018-01"},{"nctId":"NCT04088292","phase":"Phase 3","title":"Low Dose Thrombolysis, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism","status":"ACTIVE_NOT_RECRUITING","sponsor":"Rigshospitalet, Denmark","isPivotal":true,"enrollment":210,"indication":"Pulmonary Embolism","completionDate":"2024-11-30"},{"nctId":"NCT07003646","phase":"N/A","title":"Reperfusion Treatment in Acute Pulmonary Embolism: A Multicenter Observational Study in the Nordic Countries","status":"RECRUITING","sponsor":"Sahlgrenska University Hospital","isPivotal":false,"enrollment":220,"indication":"Pulmonary Embolism","completionDate":"2029-05-01"},{"nctId":"NCT04526951","phase":"Phase 3","title":"TENecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): A Randomized Placebo-controlled Trial of Early Systemic Tenecteplase Treatment in Patients With Central Retinal Artery Occlusion.","status":"COMPLETED","sponsor":"Oslo University Hospital","isPivotal":true,"enrollment":81,"indication":"Central Retinal Artery Occlusion","completionDate":"2025-06-20"},{"nctId":"NCT03452722","phase":"N/A","title":"Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA","status":"COMPLETED","sponsor":"University of Rijeka","isPivotal":false,"enrollment":88,"indication":"Hypertensive Intracerebral Hemorrhage, Intraventricular Hemorrhage","completionDate":"2018-09-01"},{"nctId":"NCT04915586","phase":"NA","title":"Short Duration High Intensity Intrapleural Alteplase With Pulmozyme (DNase) in Pleural Infection Management- Single Centre Experience","status":"COMPLETED","sponsor":"National University of Malaysia","isPivotal":false,"enrollment":30,"indication":"Loculated Empyema","completionDate":"2020-12-31"},{"nctId":"NCT06980506","phase":"N/A","title":"Imaging of Patients With Solid Tumor Cancer Via Intermediate-Size Patient Population Expanded Access Investigational New Drug (IND)","status":"AVAILABLE","sponsor":"Monopar Therapeutics","isPivotal":false,"enrollment":0,"indication":"Cancer, Solid Tumor","completionDate":""},{"nctId":"NCT01204333","phase":"Phase 2","title":"Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis (TOACT)","status":"TERMINATED","sponsor":"Jan Stam, MD, PhD","isPivotal":true,"enrollment":67,"indication":"Sinus Thrombosis, Intracranial","completionDate":"2017-10"},{"nctId":"NCT00303420","phase":"Phase 4","title":"Alteplase for Blood Flow Restoration in Hemodialysis Catheters: A Randomized Prospective Clinical Trial","status":"TERMINATED","sponsor":"University of Manitoba","isPivotal":false,"enrollment":180,"indication":"Thrombosis","completionDate":"2008-12"},{"nctId":"NCT02309970","phase":"N/A","title":"","status":"UNKNOWN","sponsor":"Rabin Medical Center","isPivotal":false,"enrollment":90,"indication":"Ischemic Stroke","completionDate":"2016-03"},{"nctId":"NCT03678090","phase":"Phase 2","title":"The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion: a Prospective Randomized Trial","status":"WITHDRAWN","sponsor":"Yale University","isPivotal":false,"enrollment":0,"indication":"Pleural Effusion, Cancer, Lung","completionDate":"2020-02-28"},{"nctId":"NCT00265005","phase":"Phase 1","title":"Dose-Ranging, Safety And Efficacy Of Cathflo(TM) Activase(R) (Alteplase) For The Treatment Of Central Catheter Occlusion In Neonates And Infants; Phase I","status":"TERMINATED","sponsor":"University of Louisville","isPivotal":false,"enrollment":12,"indication":"Thrombosis","completionDate":"2012-12"},{"nctId":"NCT05233501","phase":"NA","title":"The Effect of Low-level Laser Therapy on Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 in Gingival Crevicular Fluid of Stage 3-4, Grade C Periodontitis Patients Received","status":"COMPLETED","sponsor":"University of Beykent","isPivotal":false,"enrollment":15,"indication":"Periodontal Diseases, Periodontal Attachment Loss","completionDate":"2018-08-30"},{"nctId":"NCT03278275","phase":"Phase 2","title":"PET/CT Imaging of uPAR-expression in Patients With Neuroendocrine Tumors Using 68Ga-NOTA-AE105","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","isPivotal":false,"enrollment":116,"indication":"Neuroendocrine Tumors","completionDate":"2021-07-08"},{"nctId":"NCT02398656","phase":"Phase 3","title":"Multicentre, Prospective Randomized Open Label, Blinded-endpoint (PROBE) Controlled Trial of Thrombolysis With Low Dose Tenecteplase (TNK-tPA) Versus Standard of Care in Minor Ischemic Stroke With Pro","status":"COMPLETED","sponsor":"University of Calgary","isPivotal":true,"enrollment":1274,"indication":"Stroke, Acute","completionDate":"2024-04-10"},{"nctId":"NCT00250991","phase":"Phase 1","title":"Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke (CLEAR Stroke) Trial","status":"COMPLETED","sponsor":"University of Cincinnati","isPivotal":false,"enrollment":94,"indication":"Stroke","completionDate":"2007-07"},{"nctId":"NCT03988842","phase":"Phase 4","title":"Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism","status":"TERMINATED","sponsor":"Victor Tapson, MD","isPivotal":false,"enrollment":4,"indication":"Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism","completionDate":"2020-04-05"},{"nctId":"NCT02315898","phase":"Phase 2","title":"Safety and Efficacy of Inhaled Tissue Plasminogen Activator (tPA) for the Acute Treatment of Pediatric Plastic Bronchitis","status":"COMPLETED","sponsor":"University of Michigan","isPivotal":false,"enrollment":40,"indication":"Plastic Bronchitis, Protein-Losing Enteropathies","completionDate":"2023-06-30"},{"nctId":"NCT06797999","phase":"Phase 1","title":"A First-in-human, Phase 1/2, Multicenter, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of ADCE-D01, a Humanized Anti-human uPARAP An","status":"RECRUITING","sponsor":"Adcendo ApS","isPivotal":false,"enrollment":270,"indication":"Metastatic Soft Tissue Sarcoma, Unresectable Soft Tissue Sarcoma","completionDate":"2029-02-27"},{"nctId":"NCT06571149","phase":"Phase 4","title":"Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke on Treatment With Direct Oral Anticoagulants: DO-IT - The DOAC Intravenous Thrombolysis Trial","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","isPivotal":false,"enrollment":906,"indication":"Ischemic Stroke","completionDate":"2029-04-30"},{"nctId":"NCT00395876","phase":"Phase 3","title":"A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters","status":"COMPLETED","sponsor":"Genentech, Inc.","isPivotal":true,"enrollment":100,"indication":"Dysfunctional Central Venous Access Catheters","completionDate":""},{"nctId":"NCT01472926","phase":"Phase 2","title":"Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis - Pilot Phase (ATTEST)","status":"COMPLETED","sponsor":"NHS Greater Glasgow and Clyde","isPivotal":false,"enrollment":104,"indication":"Stroke","completionDate":"2013-12-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"therapeuticAreas":["Ophthalmology"],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"genericManufacturerList":[],"modality":"Small molecule","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}