{"id":"micronomicin","rwe":[{"pmid":"40790107","year":"2025","title":"Metabolic reprogramming enhances the susceptibility of multidrug- and carbapenem-resistant bacteria to antibiotics.","finding":"","journal":"Nature microbiology","studyType":"Clinical Study"},{"pmid":"38873542","year":"2024","title":"MedChemExpress compounds prevent neuraminidase N1 via physics- and knowledge-based methods.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"29685085","year":"2019","title":"Micronomicin/tobramycin binding with DNA: fluorescence studies using of ethidium bromide as a probe and molecular docking analysis.","finding":"","journal":"Journal of biomolecular structure & dynamics","studyType":"Clinical Study"},{"pmid":"23683397","year":"2013","title":"Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"},{"pmid":"23460973","year":"2012","title":"Simultaneous determination of purity and potency of the components of gentamycin using high-performance liquid chromatography.","finding":"","journal":"Yao xue xue bao = Acta pharmaceutica Sinica","studyType":"Clinical Study"}],"tags":[{"label":"micronomicin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"S01AA22","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gentamicin c2b","offLabel":[],"synonyms":["micronomicin sulfate","micronomicin","Gentamicin C2b","sagamicin","santemycin"],"timeline":[],"approvals":[],"brandName":"Gentamicin C2B","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"micronomicin","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. Gentamicin C2B is like a special tool that gets inside these factories and stops them from making proteins, which ultimately kills the bacteria that are making you sick.","oneSentence":"Gentamicin C2B works by binding to bacterial ribosomes and inhibiting protein synthesis.","technicalDetail":"Gentamicin C2B binds to the 30S subunit of the bacterial ribosome, specifically to the A-site, and prevents the incorporation of aminoacyl-tRNA into the growing peptide chain, thereby inhibiting protein synthesis and leading to bacterial cell death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1801","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MICRONOMICIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:31:32.859503","biosimilars":[],"competitors":[{"drugName":"chloramphenicol","drugSlug":"chloramphenicol","fdaApproval":"1950-12-08","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"natamycin","drugSlug":"natamycin","fdaApproval":"1978-10-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"gentamicin","drugSlug":"gentamicin","fdaApproval":"1970-06-19","genericCount":36,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tobramycin","drugSlug":"tobramycin","fdaApproval":"1975-06-11","patentExpiry":"Sep 12, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"benzylpenicillin","drugSlug":"benzylpenicillin","fdaApproval":"1947-02-06","relationship":"same-class"},{"drugName":"dihydrostreptomycin","drugSlug":"dihydrostreptomycin","fdaApproval":"","relationship":"same-class"},{"drugName":"rifamycin","drugSlug":"rifamycin","fdaApproval":"2018-11-16","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"erythromycin","drugSlug":"erythromycin","fdaApproval":"1964-06-24","genericCount":39,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"Polymyxin B","drugSlug":"polymyxin-b","fdaApproval":"1957-03-26","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ampicillin","drugSlug":"ampicillin","fdaApproval":"1965-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"amikacin","drugSlug":"amikacin","fdaApproval":"1981-01-22","patentExpiry":"May 15, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"netilmicin","drugSlug":"netilmicin","fdaApproval":"1983-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"kanamycin","drugSlug":"kanamycin","fdaApproval":"1973-02-13","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azithromycin","drugSlug":"azithromycin","fdaApproval":"1991-11-01","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefuroxime","drugSlug":"cefuroxime","fdaApproval":"1983-10-19","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"vancomycin","drugSlug":"vancomycin","fdaApproval":"1964-11-06","patentExpiry":"Nov 6, 2035","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"micronomicin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chloramphenicol","brandName":"chloramphenicol","genericName":"chloramphenicol","approvalYear":"1950","relationship":"same-class"},{"drugId":"chlortetracycline","brandName":"chlortetracycline","genericName":"chlortetracycline","approvalYear":"1950","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"oxytetracycline","brandName":"oxytetracycline","genericName":"oxytetracycline","approvalYear":"1964","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"gentamicin","brandName":"gentamicin","genericName":"gentamicin","approvalYear":"1970","relationship":"same-class"},{"drugId":"tobramycin","brandName":"tobramycin","genericName":"tobramycin","approvalYear":"1975","relationship":"same-class"},{"drugId":"benzylpenicillin","brandName":"benzylpenicillin","genericName":"benzylpenicillin","approvalYear":"1947","relationship":"same-class"},{"drugId":"dihydrostreptomycin","brandName":"dihydrostreptomycin","genericName":"dihydrostreptomycin","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005379","UNII":"S9AZ0R40QV","CHEBI":"CHEBI:31844","INN_ID":"5036","RXNORM":"236199","UMLSCUI":"C0066520","ChEMBL_ID":"CHEMBL373081","KEGG_DRUG":"D01821","DRUGBANK_ID":"DB13274","PUBCHEM_CID":"3037206","IUPHAR_LIGAND_ID":"12162","SECONDARY_CAS_RN":"66803-19-8","MESH_SUPPLEMENTAL_RECORD_UI":"C037545"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"2.1 hours","clearance":"1.1 mL/min/kg","volumeOfDistribution":"0.15 L/kg"},"publicationCount":63,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"S01AA22","allCodes":["S01AA22"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep","pmid":"40790107","title":"Metabolic reprogramming enhances the susceptibility of multidrug- and carbapenem-resistant bacteria to antibiotics.","journal":"Nature microbiology"},{"date":"2024 Jun 12","pmid":"38873542","title":"MedChemExpress compounds prevent neuraminidase N1 via physics- and knowledge-based methods.","journal":"RSC advances"},{"date":"2019 Apr","pmid":"29685085","title":"Micronomicin/tobramycin binding with DNA: fluorescence studies using of ethidium bromide as a probe and molecular docking analysis.","journal":"Journal of biomolecular structure & dynamics"},{"date":"2013 Jun 21","pmid":"23683397","title":"Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection.","journal":"Journal of chromatography. A"},{"date":"2012 Dec","pmid":"23460973","title":"Simultaneous determination of purity and potency of the components of gentamycin using high-performance liquid chromatography.","journal":"Yao xue xue bao = Acta pharmaceutica Sinica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gentamicin C2B, also known as Micronomicin, is a small molecule antibiotic in the micronomicin class. Its target is unknown, and it is not FDA-approved for any indications. Gentamicin C2B has a half-life of 2.1 hours, but its bioavailability and commercial status are unknown. As a result, it is not widely available or used in clinical practice. Further research is needed to fully understand its properties and potential applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}