{"id":"microgestin","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-10","effect":"Breakthrough bleeding"},{"rate":"2-5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:46:10.939478","_dailymed":{"setId":"0a372f10-41ac-4953-a2d5-a913672b3b21","title":"MICROGESTIN 1/20 ( NORETHINDRONE ACETATE/ETHINYL ESTRADIOL) KIT [MAYNE PHARMA INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The estrogen and progestin components work synergistically to inhibit the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) surges required for ovulation. Additionally, the progestin thickens cervical mucus to impede sperm penetration and alters the endometrium to prevent implantation, providing multiple layers of contraceptive protection.","oneSentence":"Microgestin is an oral contraceptive that prevents pregnancy by suppressing ovulation through a combination of norethindrone (progestin) and ethinyl estradiol (estrogen).","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:14:23.132Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral contraception for prevention of pregnancy"}]},"_fixedFields":["pubmed(2)"],"trialDetails":[{"nctId":"NCT01318005","phase":"NA","title":"Oral Contraceptive (OC) Estrogen Dose and Breast Proliferation","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2011-02-14","conditions":"Oral Contraceptive","enrollment":82},{"nctId":"NCT03856970","phase":"PHASE1","title":"Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Ironwood Pharmaceuticals, Inc.","startDate":"2019-03-11","conditions":"Healthy Volunteers","enrollment":87},{"nctId":"NCT01297348","phase":"","title":"Study Of Lybrel In Relation To Venous Thromboembolism","status":"COMPLETED","sponsor":"Pfizer","startDate":"2007-07","conditions":"Venous Thrombosis, Pulmonary Embolism, Sinus Thrombosis, Intracranial","enrollment":598682}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"recentPublications":[{"date":"2006","pmid":"30000354","title":"Contraceptives, Oral, Combined.","journal":""},{"date":"2026 Mar","pmid":"41365423","title":"[Preexisting diabetes: Expert consensus from the College of French Gynecologists and Obstetricians and from the French Society of Diabetology].","journal":"Gynecologie, obstetrique, fertilite & senologie"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ethinyl estradiol 30 μg and norethindrone 1500 μg"],"phase":"marketed","status":"active","brandName":"Microgestin®","genericName":"Microgestin®","companyName":"Ironwood Pharmaceuticals, Inc.","companyId":"ironwood-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Microgestin is an oral contraceptive that prevents pregnancy by suppressing ovulation through a combination of norethindrone (progestin) and ethinyl estradiol (estrogen). Used for Oral contraception for prevention of pregnancy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}