{"id":"miacalcin-calcitonin-salmon-nasal-spray","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nasal irritation or rhinitis"},{"rate":"5-15","effect":"Nausea"},{"rate":"2-10","effect":"Flushing"},{"rate":"5-10","effect":"Headache"},{"rate":"5-15","effect":"Nasal congestion"}]},"_chembl":{"chemblId":"CHEMBL4590044","moleculeType":"Unknown","molecularWeight":"3434.91"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcitonin salmon mimics the natural human calcitonin hormone and acts as an osteoclast inhibitor, reducing bone turnover and resorption. It also promotes renal calcium excretion and has analgesic properties in bone pain conditions. The nasal spray formulation allows systemic absorption for treatment of osteoporosis and hypercalcemia.","oneSentence":"Calcitonin salmon is a peptide hormone that binds to calcitonin receptors on osteoclasts to inhibit bone resorption and increase urinary calcium excretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:00.711Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis in postmenopausal women"},{"name":"Paget's disease of bone"},{"name":"Hypercalcemia of malignancy"}]},"trialDetails":[{"nctId":"NCT03812991","phase":"PHASE4","title":"The Use of Intranasal Calcitonin to Improve Pain and Activity in Elderly Pelvic Ring Injuries","status":"COMPLETED","sponsor":"University of Missouri-Columbia","startDate":"2019-07-01","conditions":"Pelvic Ring Fractures","enrollment":21},{"nctId":"NCT03342001","phase":"PHASE4","title":"Hypothyroidism Treated With Calcitonin","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2018-06-18","conditions":"Hypothyroidism","enrollment":11},{"nctId":"NCT00478335","phase":"NA","title":"Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2007-05","conditions":"Nephrogenic Diabetes Insipidus","enrollment":4},{"nctId":"NCT01652573","phase":"NA","title":"Calcitonin for Treating X-linked Hypophosphatemia","status":"COMPLETED","sponsor":"Yale University","startDate":"2011-03","conditions":"Hypophosphatemic Rickets, X Linked Dominant","enrollment":21},{"nctId":"NCT00754884","phase":"PHASE4","title":"Calcitonin in the Treatment of Fibromyalgia","status":"WITHDRAWN","sponsor":"Unidad de Investigacion en Enfermedades Cronico-Degenerativas","startDate":"2008-10","conditions":"Fibromyalgia","enrollment":""},{"nctId":"NCT02358304","phase":"PHASE2","title":"Efficacy of Nasal Spray Calcitonin on Recurrence of Aggressive Central Giant Cell Granuloma","status":"COMPLETED","sponsor":"Shiraz University of Medical Sciences","startDate":"2007-09","conditions":"Central Giant Cell Granuloma","enrollment":24},{"nctId":"NCT00803686","phase":"PHASE2","title":"A Study of Oral Calcitonin Given at Night to Healthy Postmenopausal Women","status":"COMPLETED","sponsor":"Tarsa Therapeutics, Inc.","startDate":"2008-12","conditions":"Phase 1 Pharmacodynamic Study","enrollment":12},{"nctId":"NCT00959764","phase":"PHASE3","title":"A Study Comparing Oral Calcitonin to Nasal Spray Calcitonin in Postmenopausal Osteoporotic Women","status":"COMPLETED","sponsor":"Tarsa Therapeutics, Inc.","startDate":"2009-06","conditions":"Osteoporosis, Postmenopausal","enrollment":565},{"nctId":"NCT00620854","phase":"PHASE2","title":"A Dose Selection Study of Oral Recombinant Salmon Calcitonin (rsCT) in Normal, Healthy, Postmenopausal Women","status":"COMPLETED","sponsor":"Tarsa Therapeutics, Inc.","startDate":"2008-02","conditions":"Osteoporosis","enrollment":24},{"nctId":"NCT00372099","phase":"PHASE3","title":"Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women","status":"COMPLETED","sponsor":"Rene Rizzoli","startDate":"2007-01","conditions":"Postmenopause","enrollment":90},{"nctId":"NCT00114803","phase":"NA","title":"Nasal Calcitonin in the Treatment of Bone Mineral Loss in Children and Adolescents With Inflammatory Bowel Disease","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2004-01","conditions":"Ulcerative Colitis, Crohn's Disease","enrollment":66},{"nctId":"NCT00486317","phase":"PHASE1","title":"Pharmacokinetics/Pharmacodynamics of Oral Salmon Calcitonin in Patients With Osteoarthritis","status":"COMPLETED","sponsor":"Nordic Bioscience A/S","startDate":"2005-10","conditions":"Osteoarthritis","enrollment":""},{"nctId":"NCT00395395","phase":"PHASE1","title":"Effects of Water and Food Intake on the Pharmacokinetics and Pharmacodynamics of Oral Salmon Calcitonin in Healthy Postmenopausal Women","status":"COMPLETED","sponsor":"Novartis","startDate":"2006-10","conditions":"Postmenopausal Osteoporosis","enrollment":56},{"nctId":"NCT00239889","phase":"PHASE4","title":"Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women","status":"COMPLETED","sponsor":"Novartis","startDate":"2002-03","conditions":"Forearm Fracture","enrollment":300}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"JAW DISORDER"},{"count":1,"reaction":"MYALGIA"},{"count":1,"reaction":"OSTEONECROSIS"},{"count":1,"reaction":"RETINAL DEGENERATION"},{"count":1,"reaction":"RETINITIS PIGMENTOSA"},{"count":1,"reaction":"TOOTH INFECTION"}],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Miacalcin","Calcitonin"],"phase":"marketed","status":"active","brandName":"Miacalcin Calcitonin Salmon Nasal Spray","genericName":"Miacalcin Calcitonin Salmon Nasal Spray","companyName":"University of Missouri-Columbia","companyId":"university-of-missouri-columbia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcitonin salmon is a peptide hormone that binds to calcitonin receptors on osteoclasts to inhibit bone resorption and increase urinary calcium excretion. Used for Osteoporosis in postmenopausal women, Paget's disease of bone, Hypercalcemia of malignancy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}