{"id":"mf-nasal-spray","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Headache"},{"rate":"3-8","effect":"Pharyngitis"},{"rate":"2-5","effect":"Epistaxis"},{"rate":"2-4","effect":"Nasal irritation"},{"rate":"1-3","effect":"Dysgeusia"}]},"_chembl":{"chemblId":"CHEMBL3321989","moleculeType":"Small molecule","molecularWeight":"296.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The active ingredient is mometasone furoate, a potent intranasal corticosteroid that binds to glucocorticoid receptors in nasal tissue, inhibiting inflammatory mediator release and reducing edema. This mechanism provides symptomatic relief of allergic and non-allergic rhinitis by decreasing nasal congestion, rhinorrhea, and sneezing.","oneSentence":"MF nasal spray is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune responses and decreasing mucus production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:59.845Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"},{"name":"Non-allergic rhinitis"},{"name":"Nasal polyps"}]},"trialDetails":[{"nctId":"NCT03705793","phase":"PHASE4","title":"Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2019-01-01","conditions":"Chronic Rhinosinusitis (Diagnosis), Allergic Rhinosinusitis, Chronic Eosinophilic Rhinosinusitis","enrollment":53},{"nctId":"NCT00779740","phase":"PHASE3","title":"Equivalency Study of Two Formulations of Mometasone Furoate Nasal Spray (Study P04419)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-02-01","conditions":"Rhinitis, Allergic, Perennial","enrollment":102},{"nctId":"NCT01135134","phase":"PHASE3","title":"Multicenter, Double-blind, Randomized, Placebo-controlled Study of Mometasone Furoate Nasal Spray in Pediatric Subjects With Perennial Allergic Rhinitis (Study P06332)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2010-06","conditions":"Rhinitis, Allergic, Perennial","enrollment":333},{"nctId":"NCT03855189","phase":"PHASE3","title":"Safety and Efficacy of Mometasone Furoate (SCH 032088) vs Beclomethasone Dipropionate or Placebo in Seasonal Allergic Rhinitis (C93-013)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1993-08-23","conditions":"Seasonal Allergic Rhinitis","enrollment":345},{"nctId":"NCT00783224","phase":"PHASE3","title":"A Comparative Study of Mometasone Furoate Nasal Spray and Fluticasone Propionate Nasal Spray in Patients With Perennial Allergic Rhinitis (Study P04512)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2005-09","conditions":"Perennial Allergic Rhinitis","enrollment":351},{"nctId":"NCT03401229","phase":"PHASE3","title":"Efficacy and Safety Study of Benralizumab for Patients With Severe Nasal Polyposis","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2018-01-15","conditions":"Nasal Polyposis","enrollment":413},{"nctId":"NCT03085797","phase":"PHASE3","title":"Effect of Mepolizumab in Severe Bilateral Nasal Polyps","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2017-05-25","conditions":"Nasal Polyps","enrollment":414},{"nctId":"NCT02397915","phase":"PHASE4","title":"Patient Preference Study of Fluticasone Furoate and Mometasone Furoate Nasal Sprays","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-03-26","conditions":"Rhinitis, Allergic, Perennial and Seasonal","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"MF nasal spray","genericName":"MF nasal spray","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"MF nasal spray is a corticosteroid that reduces inflammation in the nasal passages by suppressing immune responses and decreasing mucus production. Used for Allergic rhinitis (seasonal and perennial), Non-allergic rhinitis, Nasal polyps.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}