{"id":"metvix-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Phototoxic reaction/photosensitivity"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Edema"},{"rate":null,"effect":"Crusting"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metvix is a prodrug that penetrates into cells and is converted to protoporphyrin IX, a photosensitizer. When exposed to red light (630 nm wavelength), it generates singlet oxygen and reactive oxygen species that cause selective destruction of abnormal tissue. This mechanism is used in photodynamic therapy (PDT) for topical treatment of skin lesions.","oneSentence":"Metvix (methyl aminolevulinate) is a photosensitizing agent that accumulates in abnormal cells and generates reactive oxygen species when activated by light, destroying target lesions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:13.177Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"},{"name":"Basal cell carcinoma (superficial and nodular)"},{"name":"Bowen's disease"}]},"trialDetails":[{"nctId":"NCT07381972","phase":"PHASE3","title":"Photodynamic Therapy Associated With Sonodynamic Therapy for the Treatment of Nodular Basal Cell Carcinoma","status":"RECRUITING","sponsor":"University of Sao Paulo","startDate":"2025-11-24","conditions":"Nodular Basal Cell Carcinoma of Skin","enrollment":142},{"nctId":"NCT07290959","phase":"NA","title":"Indoor Daylight Photodynamic Therapy is an Effective, First-line Treatment for AK, But Its Feasibility is Limited by the Time Required for the Illumination (2 Hours). 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Used for Actinic keratosis, Basal cell carcinoma (superficial and nodular), Bowen's disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}