{"id":"meturedepa","rwe":[{"pmid":"4895430","year":"1968","title":"Effects of meturedepa (NSC-51325) in 233 patients with advanced cancer. Eastern Clinical Drug Evaluation Program.","finding":"","journal":"Cancer chemotherapy reports","studyType":"Clinical Study"},{"pmid":"14184043","year":"1964","title":"COMBINED USE OF AB-132 (METUREDEPA, TURLOC) AND X-IRRADIATION IN THE MANAGEMENT OF ADVANCED BRONCHOGENIC CARCINOMA.","finding":"","journal":"Cancer","studyType":"Clinical Study"}],"tags":[{"label":"meturedepa","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"turloc","offLabel":[],"synonyms":["AB-132","turloc","meturedepa","dimethylurethimine"],"timeline":[],"approvals":[],"brandName":"Turloc","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"meturedepa","explanation":"Imagine your body's cells have locks on them, and Turloc has a key that fits into those locks. When Turloc binds to its target, it helps to regulate the activity of the cells, which can lead to various therapeutic benefits. However, the exact mechanism of action and how Turloc interacts with its target are not well-understood at this time.","oneSentence":"Turloc works by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Turloc's mechanism of action involves binding to its target, which is likely a protein or enzyme, to produce a downstream effect that leads to its therapeutic benefits. The exact molecular details of this interaction are not well-documented, but it is thought to involve a reversible binding process that alters the activity of the target protein."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3784","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METUREDEPA","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:42:46.240528","biosimilars":[],"competitors":[],"genericName":"meturedepa","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"43255365IF","CHEBI":"CHEBI:135138","INN_ID":"1423","UMLSCUI":"C0609940","ChEMBL_ID":"CHEMBL280685","KEGG_DRUG":"D05018","PUBCHEM_CID":"15456","MESH_SUPPLEMENTAL_RECORD_UI":"C024217"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1968 Oct","pmid":"4895430","title":"Effects of meturedepa (NSC-51325) in 233 patients with advanced cancer. Eastern Clinical Drug Evaluation Program.","journal":"Cancer chemotherapy reports"},{"date":"1964 Jul","pmid":"14184043","title":"COMBINED USE OF AB-132 (METUREDEPA, TURLOC) AND X-IRRADIATION IN THE MANAGEMENT OF ADVANCED BRONCHOGENIC CARCINOMA.","journal":"Cancer"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Turloc (METUREDEPA) is a small molecule drug in the meturedepa class, but information on its target, approved indications, and commercial status is limited. As a pharma professional, it is essential to note that Turloc's development history, pharmacokinetic properties, and safety profile are not well-documented. Further research is necessary to understand Turloc's mechanism of action and potential therapeutic applications. The lack of information on Turloc's target and approved indications suggests that it may be an investigational or experimental compound. More data is required to assess its clinical utility and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}