{"id":"metronidazole-topical-gel-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Dryness or peeling"},{"rate":null,"effect":"Metallic taste (if absorbed systemically)"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metronidazole is a nitroimidazole that penetrates microbial cells and is reduced to reactive intermediates that damage DNA and inhibit nucleic acid synthesis. When applied topically as a gel, it reduces pathogenic bacteria and protozoa while also possessing anti-inflammatory properties that help resolve rosacea and other inflammatory skin conditions.","oneSentence":"Metronidazole disrupts bacterial and protozoal DNA, causing cell death and reducing inflammation in topical infections.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:01.778Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rosacea (topical)"},{"name":"Bacterial vaginosis (topical)"},{"name":"Inflammatory acne"},{"name":"Perioral dermatitis"}]},"trialDetails":[{"nctId":"NCT05929794","phase":"PHASE4","title":"Pharmacokinetics of Transdermal Metronidazole","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Iowa","startDate":"2024-02-26","conditions":"Healthy","enrollment":24},{"nctId":"NCT07392047","phase":"PHASE4","title":"Metronidazole 2% Gel Versus Clindamycin 1% Gel for Moderate Acne Vulgaris","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2026-02","conditions":"Acne Vulgaris","enrollment":60},{"nctId":"NCT01426269","phase":"PHASE4","title":"Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-09","conditions":"Rosacea","enrollment":235},{"nctId":"NCT00668655","phase":"","title":"An Evaluation of the Cosmetic Appearance of Metronidazole Gel (MetroGel®) 1%","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-02","conditions":"Rosacea","enrollment":30},{"nctId":"NCT02393937","phase":"PHASE3","title":"A Therapeutic Equivalence Study of Two Metronidazole Gel 1% Topical Treatments of Rosacea","status":"COMPLETED","sponsor":"bioRASI, LLC","startDate":"2015-02","conditions":"Papulopustular Rosacea, Erythematotelangiectatic Rosacea","enrollment":963},{"nctId":"NCT04125706","phase":"NA","title":"Locally Delivered Antibiotics for the Treatment of Periodontitis","status":"UNKNOWN","sponsor":"Riyadh Elm University","startDate":"2019-11-01","conditions":"Periodontitis","enrollment":44},{"nctId":"NCT02052999","phase":"PHASE2","title":"Study to Evaluate the Efficacy and Safety of PAC-14028 Cream in Rosacea Patients","status":"COMPLETED","sponsor":"Amorepacific Corporation","startDate":"2013-02","conditions":"Erythematotelangiectatic Rosacea, Papulopustular Rosacea","enrollment":80},{"nctId":"NCT01513863","phase":"PHASE1","title":"A Therapeutic Equivalence Study of Two Metronidazole 1%Topical Gel Treatments for Patients With Rosacea","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2011-08","conditions":"Rosacea","enrollment":602},{"nctId":"NCT00495313","phase":"PHASE4","title":"Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens","status":"COMPLETED","sponsor":"CollaGenex Pharmaceuticals","startDate":"2007-03","conditions":"Rosacea","enrollment":91}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Metronidazole Topical Gel 2%","genericName":"Metronidazole Topical Gel 2%","companyName":"Jinnah Postgraduate Medical Centre","companyId":"jinnah-postgraduate-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metronidazole disrupts bacterial and protozoal DNA, causing cell death and reducing inflammation in topical infections. Used for Rosacea (topical), Bacterial vaginosis (topical), Inflammatory acne.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}