{"id":"metronidazole-st14","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Metallic taste"},{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"1-2","effect":"Peripheral neuropathy (with prolonged use)"},{"rate":null,"effect":"Disulfiram-like reaction with alcohol"},{"rate":"5-10","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL137","moleculeType":"Small molecule","molecularWeight":"171.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug is activated by anaerobic bacteria and parasites through reduction of its 5-nitro group, generating cytotoxic free radicals that damage DNA and prevent replication. This mechanism makes it effective against obligate anaerobes and certain protozoan parasites. It has no activity against aerobic organisms due to their inability to activate the drug.","oneSentence":"Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and parasitic DNA by generating reactive oxygen species after reduction of its nitro group.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:59.405Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaerobic bacterial infections (intra-abdominal, gynecological, respiratory)"},{"name":"Trichomoniasis"},{"name":"Giardiasis"},{"name":"Amebiasis"},{"name":"Clostridioides difficile infection"},{"name":"Bacterial vaginosis"}]},"trialDetails":[{"nctId":"NCT03208426","phase":"PHASE4","title":"Sequential Versus Quadruple Therapy in the Second-line Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-10-01","conditions":"Helicobacter Pylori Infection","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Flagyl"],"phase":"marketed","status":"active","brandName":"Metronidazole (ST14)","genericName":"Metronidazole (ST14)","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metronidazole is a nitroimidazole antibiotic that disrupts bacterial and parasitic DNA by generating reactive oxygen species after being reduced in anaerobic environments. Used for Anaerobic bacterial infections, Trichomoniasis, Amebiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}