{"id":"metronidazole-gel-versus-placebo-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation or burning"},{"rate":null,"effect":"Metallic taste (systemic)"},{"rate":null,"effect":"Nausea (systemic)"},{"rate":null,"effect":"Local application site reactions"}]},"_chembl":{"chemblId":"CHEMBL137","moleculeType":"Small molecule","molecularWeight":"171.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metronidazole is reduced by anaerobic organisms to form reactive intermediates that damage bacterial DNA and proteins, leading to cell death. It is effective against anaerobic bacteria and parasites but has no activity against aerobic organisms. The gel formulation allows topical delivery for localized infections or conditions.","oneSentence":"Metronidazole is a nitroimidazole antibiotic that disrupts bacterial DNA by generating reactive oxygen species, killing anaerobic bacteria and certain protozoa.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:05.076Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial vaginosis (topical gel formulation)"},{"name":"Rosacea (topical gel formulation)"},{"name":"Anaerobic bacterial infections (systemic formulation)"}]},"trialDetails":[{"nctId":"NCT00140764","phase":"PHASE3","title":"Intravaginal Treatment of Disturbances of Vaginal Flora Among HIV Infected and Uninfected Women in Malawi","status":"COMPLETED","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2003-01","conditions":"Bacterial Vaginosis, Trichomonas Vaginitis, Urogenital Diseases","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Metronidazole gel versus placebo gel","genericName":"Metronidazole gel versus placebo gel","companyName":"Johns Hopkins Bloomberg School of Public Health","companyId":"johns-hopkins-bloomberg-school-of-public-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metronidazole is a nitroimidazole antibiotic that disrupts bacterial DNA by generating reactive oxygen species, killing anaerobic bacteria and certain protozoa. Used for Bacterial vaginosis (topical gel formulation), Rosacea (topical gel formulation), Anaerobic bacterial infections (systemic formulation).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}