{"id":"metronidazole-and-doxycycline","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"5-20","effect":"Diarrhea"},{"rate":"5-15","effect":"Metallic taste (metronidazole)"},{"rate":"1-3","effect":"Photosensitivity (doxycycline)"},{"rate":"1-5","effect":"Esophageal irritation"},{"rate":"5-10","effect":"Vaginal candidiasis"}]},"_chembl":{"chemblId":"CHEMBL2447928","moleculeType":"Small molecule","molecularWeight":"746.90"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metronidazole is a nitroimidazole that generates reactive oxygen species to damage bacterial DNA, particularly effective against anaerobes. Doxycycline is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Together, they provide synergistic coverage against mixed aerobic and anaerobic infections.","oneSentence":"Metronidazole and doxycycline together provide broad-spectrum antimicrobial coverage by disrupting bacterial DNA synthesis and protein production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:58.666Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mixed aerobic-anaerobic bacterial infections"},{"name":"Intra-abdominal infections"},{"name":"Pelvic inflammatory disease"},{"name":"Periodontal infections"}]},"trialDetails":[{"nctId":"NCT05894954","phase":"PHASE3","title":"Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment","status":"COMPLETED","sponsor":"Alzheimer's Prevention and Reversal Project, Inc.","startDate":"2023-07-31","conditions":"Mild Cognitive Impairment, Dementia, Mild","enrollment":73},{"nctId":"NCT07405684","phase":"PHASE4","title":"Fecal Molecular Susceptibility-guided Hp First-line Therapy","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-02-28","conditions":"HELICOBACTER PYLORI INFECTIONS","enrollment":544},{"nctId":"NCT07405697","phase":"PHASE4","title":"Fecal Molecular Susceptibility-guided Hp Rescue Therapy","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-02-28","conditions":"Helicobacter Pylori Infection","enrollment":290},{"nctId":"NCT05977868","phase":"PHASE4","title":"Comparing Oral Versus Parenteral Antimicrobial Therapy","status":"TERMINATED","sponsor":"West Virginia University","startDate":"2023-08-04","conditions":"Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection","enrollment":94},{"nctId":"NCT05448937","phase":"PHASE2, PHASE3","title":"Lesion Sterilization And Tissue Repair Versus Zinc Oxide And Eugenol For Treatment of Necrotic Primary Molars","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-10-01","conditions":"Necrotic Primary Molars","enrollment":60},{"nctId":"NCT06570863","phase":"NA","title":"To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT","status":"COMPLETED","sponsor":"Dr fizza khalid","startDate":"2022-07-01","conditions":"Periodontitis, Adult","enrollment":120},{"nctId":"NCT06050824","phase":"PHASE4","title":"A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection","status":"COMPLETED","sponsor":"Helwan University","startDate":"2022-07-21","conditions":"H. Pylori Infection","enrollment":200},{"nctId":"NCT04723069","phase":"PHASE2","title":"Efficacy and Safety of Fuke Qianjin Capsule in Patients With Pelvic Inflammatory Diseases","status":"COMPLETED","sponsor":"University of Karachi","startDate":"2021-09-21","conditions":"Pelvic Inflammatory Disease","enrollment":198},{"nctId":"NCT05205993","phase":"PHASE2","title":"Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis","status":"UNKNOWN","sponsor":"Genesis Athens Clinic","startDate":"2021-01-19","conditions":"Chronic Endometritis","enrollment":90},{"nctId":"NCT05445362","phase":"NA","title":"Efficacy of Diode Laser in Maturogenesis of Immature Teeth With Necrotic Pulps","status":"COMPLETED","sponsor":"Reham Hassan","startDate":"2019-02-01","conditions":"Effects of the Elements","enrollment":39},{"nctId":"NCT01426269","phase":"PHASE4","title":"Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2011-09","conditions":"Rosacea","enrollment":235},{"nctId":"NCT03986996","phase":"PHASE2","title":"Antimicrobial Therapy for Ulcerative Colitis (UC)","status":"TERMINATED","sponsor":"Wolfson Medical Center","startDate":"2019-07-25","conditions":"Ulcerative Colitis","enrollment":20},{"nctId":"NCT02345733","phase":"PHASE4","title":"Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis","status":"COMPLETED","sponsor":"Prof. Arie Levine","startDate":"2015-09-01","conditions":"Ulcerative Colitis (UC)","enrollment":20},{"nctId":"NCT02366884","phase":"PHASE2","title":"Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011)","status":"UNKNOWN","sponsor":"Dr. Frank Arguello Cancer Clinic","startDate":"2011-07-26","conditions":"Neoplasms","enrollment":250},{"nctId":"NCT05040334","phase":"PHASE4","title":"Role of Prophylactic Antibiotics in Preventing Pelvic Infection After Surgical Evacuation","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-01-01","conditions":"Antibiotics Causing Adverse Effects in Therapeutic Use","enrollment":138},{"nctId":"NCT05293977","phase":"NA","title":"Short-Term Use of Antibiotics and Adherence Level","status":"COMPLETED","sponsor":"Jordan University of Science and Technology","startDate":"2020-08-03","conditions":"Acute Infection","enrollment":589},{"nctId":"NCT02033408","phase":"NA","title":"Manipulating the Microbiome in IBD by Antibiotics and FMT","status":"COMPLETED","sponsor":"Shaare Zedek Medical Center","startDate":"2014-01","conditions":"Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe, Crohn's Colitis","enrollment":28},{"nctId":"NCT05061732","phase":"PHASE4","title":"Helicobacter Pylori Eradication and Follow-up","status":"RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2021-09-30","conditions":"Helicobacter Pylori Infection","enrollment":4447},{"nctId":"NCT05018923","phase":"PHASE4","title":"Tetracycline Versus Doxycycline for HP Rescue Therapy","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2021-08-24","conditions":"Helicobacter Pylori Infection","enrollment":242},{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":"Osteomyelitis","enrollment":11},{"nctId":"NCT02606032","phase":"PHASE2","title":"Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis","status":"COMPLETED","sponsor":"Hamilton Health Sciences Corporation","startDate":"2016-05","conditions":"Ulcerative Colitis","enrollment":75},{"nctId":"NCT04082559","phase":"NA","title":"Biomarker-based Multidisciplinary Team (Bio-MDT) Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2019-06-11","conditions":"Inflammatory Bowel Diseases","enrollment":170},{"nctId":"NCT04447625","phase":"PHASE2","title":"Intrauterine Antibiotic Infusion in Treating Chronic Endometritis and Restoring Reproductive Dynamics","status":"COMPLETED","sponsor":"Genesis Athens Clinic","startDate":"2017-03-01","conditions":"Chronic Endometritis","enrollment":80},{"nctId":"NCT00855595","phase":"PHASE4","title":"Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2009-02","conditions":"Papulopustular Rosacea","enrollment":207},{"nctId":"NCT04039412","phase":"PHASE4","title":"Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt","status":"COMPLETED","sponsor":"Ayman Magd Eldin Mohammad Sadek","startDate":"2018-06-01","conditions":"Helicobacter Pylori Infection","enrollment":330},{"nctId":"NCT03727620","phase":"PHASE1, PHASE2","title":"Doxycycline in the Treatment of Aggressive Periodontitis","status":"COMPLETED","sponsor":"Mohammed V Souissi University","startDate":"2014-01-06","conditions":"Aggressive Periodontitis","enrollment":24},{"nctId":"NCT02894268","phase":"PHASE4","title":"Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy","status":"UNKNOWN","sponsor":"Sir Run Run Shaw Hospital","startDate":"2016-02","conditions":"Helicobacter Pylori Infection","enrollment":300},{"nctId":"NCT03533231","phase":"PHASE4","title":"Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old.","status":"COMPLETED","sponsor":"Tariq Yehia","startDate":"2015-01-16","conditions":"Dental Pulp Necrosis, Periapical Abscess, Root Canal Infection","enrollment":40},{"nctId":"NCT03322488","phase":"NA","title":"Fistulodesis Pilot Study for Closure of Perianal Fistulae","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2017-06-20","conditions":"Perianal Fistula, Crohn Disease","enrollment":40},{"nctId":"NCT00016835","phase":"PHASE2","title":"Treating Periodontal Infection: Effects on Glycemic","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2001-10-17","conditions":"Periodontal Disease, Diabetes Mellitus, Type 2","enrollment":46},{"nctId":"NCT02217722","phase":"NA","title":"Use of the Ulcerative Colitis Diet for Induction of Remission","status":"TERMINATED","sponsor":"Prof. Arie Levine","startDate":"2014-10","conditions":"Ulcerative Colitis (UC)","enrollment":9},{"nctId":"NCT00066066","phase":"PHASE2","title":"Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers","status":"COMPLETED","sponsor":"The Forsyth Institute","startDate":"2003-07","conditions":"Periodontitis, Periodontal Diseases","enrollment":146},{"nctId":"NCT00355602","phase":"NA","title":"Antibiotics for the Treatment of Ulcerative Colitis","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2006-07","conditions":"Colitis, Ulcerative","enrollment":40},{"nctId":"NCT00353743","phase":"NA","title":"The Use of Antibiotics After Hospital Discharge in Septic Abortion","status":"TERMINATED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2006-05","conditions":"Abortion, Septic","enrollment":56},{"nctId":"NCT00495313","phase":"PHASE4","title":"Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens","status":"COMPLETED","sponsor":"CollaGenex Pharmaceuticals","startDate":"2007-03","conditions":"Rosacea","enrollment":91},{"nctId":"NCT00713999","phase":"NA","title":"Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2001-08","conditions":"Sexually Transmitted Infections, Schistosoma Haematobium","enrollment":680},{"nctId":"NCT00376493","phase":"PHASE4","title":"Prolonged Treatment for Infected Abortion After Hospital Discharge.","status":"TERMINATED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2006-05","conditions":"Septic Abortion","enrollment":56},{"nctId":"NCT00484250","phase":"PHASE2","title":"Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other","status":"COMPLETED","sponsor":"Mashhad University of Medical Sciences","startDate":"2005-09","conditions":"Oral Lichen Planus","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"metronidazole and doxycycline","genericName":"metronidazole and doxycycline","companyName":"Hospital de Clinicas de Porto Alegre","companyId":"hospital-de-clinicas-de-porto-alegre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metronidazole and doxycycline together provide broad-spectrum antimicrobial coverage by disrupting bacterial DNA synthesis and protein production. Used for Mixed aerobic-anaerobic bacterial infections, Intra-abdominal infections, Pelvic inflammatory disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}