{"id":"metoprolole-selo-zok","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"3-5","effect":"Dyspnea"},{"rate":"1-3","effect":"Depression"},{"rate":"1-3","effect":"Sexual dysfunction"}]},"_chembl":{"chemblId":"CHEMBL2062335","moleculeType":"Small molecule","molecularWeight":"684.82"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metoprolol competitively blocks beta-1 adrenergic receptors on cardiac tissue, decreasing heart contractility and heart rate. This reduces cardiac oxygen demand and blood pressure, making it effective for hypertension and angina. It also has antiarrhythmic properties useful in atrial fibrillation management.","oneSentence":"Metoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate and blood pressure by blocking the effects of norepinephrine and epinephrine on the heart.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:53.991Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Acute myocardial infarction"},{"name":"Heart failure"},{"name":"Atrial fibrillation"}]},"trialDetails":[{"nctId":"NCT00885651","phase":"PHASE4","title":"Ability of Metoprolol to Alter the Exercise Induced Elevation of Catecholamines","status":"UNKNOWN","sponsor":"Rigshospitalet, Denmark","startDate":"2008-09","conditions":"Heart Failure","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Metoprolole (Selo-Zok ®)","genericName":"Metoprolole (Selo-Zok ®)","companyName":"Rigshospitalet, Denmark","companyId":"rigshospitalet-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoprolol is a selective beta-1 adrenergic receptor antagonist that reduces heart rate, blood pressure, and cardiac workload. Used for Hypertension, Angina pectoris, Myocardial infarction (secondary prevention).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}