{"id":"metoprolol-met","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"3-5","effect":"Hypotension"},{"rate":"3-5","effect":"Dyspnea"},{"rate":"1-3","effect":"Depression"},{"rate":"1-3","effect":"Sexual dysfunction"}]},"_chembl":null,"_dailymed":{"setId":"14ab9921-4651-4abc-92dc-aab1719b6bb0","title":"METOPROLOL SUCCINATE TABLET, FILM COATED, EXTENDED RELEASE [MAJOR PHARMACEUTICALS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metoprolol selectively blocks beta-1 adrenergic receptors on the heart and blood vessels, reducing the effects of norepinephrine and epinephrine. This decreases heart rate, contractility, and blood pressure, thereby reducing myocardial oxygen demand. It is used to manage hypertension, angina, heart failure, and arrhythmias.","oneSentence":"Metoprolol is a beta-1 selective adrenergic receptor antagonist that reduces heart rate, blood pressure, and cardiac workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:59.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"},{"name":"Acute myocardial infarction"},{"name":"Heart failure"},{"name":"Atrial fibrillation"},{"name":"Essential tremor"}]},"trialDetails":[{"nctId":"NCT06967194","phase":"NA","title":"Early Beta Blocker Administration in STEMI Patients With SCAI B Status","status":"RECRUITING","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2025-05-21","conditions":"ST Segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock Post Myocardial Infarction","enrollment":200},{"nctId":"NCT00142584","phase":"PHASE3","title":"Evaluation of the Long-term Safety and Tolerability of Metoprolol Versus Nebivolol in Patients With Hypertension","status":"COMPLETED","sponsor":"Mylan Bertek Pharmaceuticals","startDate":"2005-08","conditions":"Hypertension","enrollment":336},{"nctId":"NCT04740840","phase":"PHASE2, PHASE3","title":"Anti Inflammatory Treatment of Hypertension","status":"COMPLETED","sponsor":"Affiliated Hospital of North Sichuan Medical College","startDate":"2010-05-01","conditions":"Hypertension","enrollment":200},{"nctId":"NCT01337674","phase":"PHASE1","title":"Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2011-04-01","conditions":"Hypertension","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":108,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["metoprolol 25mg"],"phase":"marketed","status":"active","brandName":"Metoprolol (MET)","genericName":"Metoprolol (MET)","companyName":"Tel-Aviv Sourasky Medical Center","companyId":"tel-aviv-sourasky-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoprolol is a beta-1 selective adrenergic receptor antagonist that reduces heart rate, blood pressure, and cardiac workload. Used for Hypertension, Angina pectoris, Acute myocardial infarction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}