{"id":"metoprolol-hct","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL2356097","moleculeType":"Small molecule","molecularWeight":"652.83"},"_fixedAt":"2026-03-30T17:40:32.459767","_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking the effects of epinephrine, metoprolol/HCT reduces the heart rate and blood pressure, which can help to prevent heart failure and reduce the risk of stroke. The diuretic effect of HCT helps to remove excess fluid from the body, further reducing blood pressure.","oneSentence":"Metoprolol/HCT is a beta-blocker that works by blocking the effects of the hormone epinephrine, and also has a diuretic effect to reduce blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:03.529Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Atrial fibrillation for stroke prevention"}]},"_fixedFields":["pubmed(15)"],"trialDetails":[{"nctId":"NCT00649688","phase":"PHASE1","title":"Fasting Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg and Lopressor HCT® Tablets 100/50 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2003-01","conditions":"Healthy","enrollment":32},{"nctId":"NCT00649233","phase":"PHASE1","title":"Food Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg to Lopressor HCT® Tablets 100/50 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2003-01","conditions":"Healthy","enrollment":32},{"nctId":"NCT00000620","phase":"PHASE3","title":"Action to Control Cardiovascular Risk in Diabetes (ACCORD)","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1999-09","conditions":"Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia","enrollment":10251},{"nctId":"NCT00679653","phase":"PHASE3","title":"Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives","status":"COMPLETED","sponsor":"Abbott","startDate":"2002-02","conditions":"Obesity, Hypertension","enrollment":171}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"DYSPNOEA"},{"count":2,"reaction":"NAUSEA"},{"count":1,"reaction":"ABDOMINAL DISCOMFORT"},{"count":1,"reaction":"BLOOD PRESSURE INADEQUATELY CONTROLLED"},{"count":1,"reaction":"BLOOD URINE PRESENT"},{"count":1,"reaction":"BURNING SENSATION"},{"count":1,"reaction":"CARDIAC FAILURE CONGESTIVE"},{"count":1,"reaction":"CHEST DISCOMFORT"},{"count":1,"reaction":"CONFUSIONAL STATE"},{"count":1,"reaction":"DIARRHOEA"}],"_approvalHistory":[],"publicationCount":15,"recentPublications":[{"date":"2025 Apr 2","pmid":"39786370","title":"Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants.","journal":"Cancer discovery"},{"date":"2023 Apr","pmid":"37354687","title":"THE NITROSAMINE CONTAMINATION IN BETA BLOCKERS (BISOPROLOL/METOPROLOL), ACE INHIBITORS (LISINOPRIL/PERINDOPRIL), THIAZIDES DIURETICS (HCT), CALCIUM CHANNEL BLOCKERS (AMLODIPINE/FELODIPINE), SARTANS (CANDESARTAN) AND ТHE SUBSEQUENT SKIN CANCER DEVELOPMENT AND PROGRESSION: APOCALYPSE NOW.","journal":"Georgian medical news"},{"date":"2019 Feb 5","pmid":"30439665","title":"Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2014 Oct","pmid":"25010389","title":"Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"2014","pmid":"24345239","title":"Some ozone advanced oxidation processes to improve the biological removal of selected pharmaceutical contaminants from urban wastewater.","journal":"Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"metoprolol/HCT","genericName":"metoprolol/HCT","companyName":"Abbott","companyId":"abbott","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoprolol/HCT is a beta-blocker that works by blocking the effects of the hormone epinephrine, and also has a diuretic effect to reduce blood pressure. Used for Hypertension, Atrial fibrillation for stroke prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}