{"id":"metopon","rwe":[{"pmid":"33351432","year":"2026","title":"Trigonocephaly.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"23880538","year":"2013","title":"Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.","finding":"","journal":"Bioorganic & medicinal chemistry letters","studyType":"Clinical Study"},{"pmid":"9059844","year":"1997","title":"14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"9142400","year":"1997","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956.","finding":"","journal":"British journal of pharmacology","studyType":"Clinical Study"},{"pmid":"8788432","year":"1995","title":"Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methyldihydromorphinone","offLabel":[],"synonyms":["metopone","metopon hydrochloride","metopon","methyldihydromorphinone","5-Methyldihydromorphinone","metopon HCl"],"timeline":[],"approvals":[],"brandName":"Methyldihydromorphinone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your brain has special locks called opioid receptors. METOPON is a key that fits into these locks, which helps to block pain signals. This can provide relief from pain, but it can also have side effects and risks, especially when used improperly.","oneSentence":"METOPON is a synthetic opioid that binds to opioid receptors in the brain to produce analgesic effects.","technicalDetail":"METOPON is a μ-opioid receptor agonist that activates the G-protein coupled receptor pathway, leading to the inhibition of adenylate cyclase and the subsequent reduction of pain transmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1785","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METOPON","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:27:19.525297","biosimilars":[],"competitors":[],"genericName":"metopon","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001549","UNII":"94XZ1CC69D","CHEBI":"CHEBI:135267","INN_ID":"4189","UMLSCUI":"C0625593","ChEMBL_ID":"CHEMBL2110992","PUBCHEM_CID":"5359353","SECONDARY_CAS_RN":"124-92-5","MESH_SUPPLEMENTAL_RECORD_UI":"C046877"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":28,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan","pmid":"33351432","title":"Trigonocephaly.","journal":""},{"date":"2013 Sep 1","pmid":"23880538","title":"Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.","journal":"Bioorganic & medicinal chemistry letters"},{"date":"1997 Feb 12","pmid":"9059844","title":"14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists.","journal":"European journal of pharmacology"},{"date":"1997 Feb","pmid":"9142400","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956.","journal":"British journal of pharmacology"},{"date":"1995 Dec 27","pmid":"8788432","title":"Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors.","journal":"European journal of pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methyldihydromorphinone, also known as Metopon, is a small molecule. It is a synthetic opioid with various synonyms, including 5-METHYLDIHYDROMORPHINONE, IDS-NM-006, and METHYLDIHYDROMORPHINONE.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}