{"id":"metolazone-concurrently-with-furosemide","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (with high-dose furosemide)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL35","moleculeType":"Small molecule","molecularWeight":"330.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metolazone is a thiazide-like diuretic that inhibits sodium chloride reabsorption in the distal convoluted tubule, while furosemide is a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle. When used concurrently, they produce a synergistic diuretic effect that is more potent than either agent alone, particularly useful in patients with severe fluid overload or diuretic resistance.","oneSentence":"Metolazone and furosemide together act as synergistic diuretics that block sodium reabsorption at different nephron sites to produce enhanced fluid and electrolyte excretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:54.457Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema and fluid overload in heart failure"},{"name":"Edema in renal disease"},{"name":"Hypertension"},{"name":"Diuretic-resistant edema"}]},"trialDetails":[{"nctId":"NCT03746002","phase":"PHASE4","title":"Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2019-01-01","conditions":"Fluid Overload, Heart Failure Acute","enrollment":3}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zaroxolyn"],"phase":"marketed","status":"active","brandName":"Metolazone concurrently with furosemide","genericName":"Metolazone concurrently with furosemide","companyName":"University of Maryland, Baltimore","companyId":"university-of-maryland-baltimore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metolazone and furosemide together act as synergistic diuretics that block sodium reabsorption at different nephron sites to enhance fluid and electrolyte excretion. Used for Edema and fluid overload in heart failure, Edema associated with renal disease, Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}