{"id":"metofenazate","rwe":[{"pmid":"1281879","year":"1992","title":"Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase.","finding":"","journal":"The Journal of pharmacology and experimental therapeutics","studyType":"Clinical Study"},{"pmid":"1280915","year":"1992","title":"Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner.","finding":"","journal":"Allergy","studyType":"Clinical Study"},{"pmid":"2449225","year":"1987","title":"Metofenazate as a more selective calmodulin inhibitor than trifluoperazine.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"3161313","year":"1985","title":"[Effect of drugs on granulocyte motility].","finding":"","journal":"Allergie und Immunologie","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"frenolone","offLabel":[],"synonyms":["metofenazate difumarate","metofenazate fumarate","perphenazintrimethoxybenzoate","frenolone","phrenolon","metofenazate","methophenazine"],"timeline":[],"approvals":[],"brandName":"Frenolone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like locks, and Frenolone is a key that fits into those locks. When it binds to the right lock, it can turn on or off certain cellular processes to help treat a disease or condition. This is a simplified way of understanding how small molecule drugs like Frenolone work at a molecular level.","oneSentence":"Frenolone works by binding to specific proteins or receptors in the body to produce a therapeutic effect.","technicalDetail":"Frenolone's exact mechanism of action is unknown, but as a small molecule, it is likely to interact with specific proteins or receptors through non-covalent binding, potentially modulating downstream signaling pathways to produce its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3357","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METOFENAZATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:27:12.298172","biosimilars":[],"competitors":[],"genericName":"metofenazate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"27J5OW8OGT","CHEBI":"CHEBI:59116","INN_ID":"2110","UMLSCUI":"C0066466","ChEMBL_ID":"CHEMBL2105229","PUBCHEM_CID":"9800","SECONDARY_CAS_RN":"522-23-6","MESH_SUPPLEMENTAL_RECORD_UI":"C008520"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1992 Dec","pmid":"1281879","title":"Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase.","journal":"The Journal of pharmacology and experimental therapeutics"},{"date":"1992 Aug","pmid":"1280915","title":"Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner.","journal":"Allergy"},{"date":"1987 Sep","pmid":"2449225","title":"Metofenazate as a more selective calmodulin inhibitor than trifluoperazine.","journal":"Arzneimittel-Forschung"},{"date":"1985","pmid":"3161313","title":"[Effect of drugs on granulocyte motility].","journal":"Allergie und Immunologie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Frenolone, also known as Metofenazate, is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it is not FDA approved for any indications. As a small molecule, it is likely to work by interacting with specific biological molecules to produce a therapeutic effect. However, without more information, it is difficult to provide a comprehensive summary of its use and safety considerations. Further research is needed to determine its potential as a therapeutic agent.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}