{"id":"metoclopramide-hydrochloride-monohydrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Tardive dyskinesia"},{"rate":"10-20","effect":"Restlessness / Akathisia"},{"rate":"10-15","effect":"Drowsiness"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL1200940","moleculeType":"Small molecule","molecularWeight":"354.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metoclopramide acts as a dopamine antagonist at the chemoreceptor trigger zone, suppressing nausea and vomiting signals. Simultaneously, it enhances acetylcholine sensitivity in gastric smooth muscle, promoting stronger contractions and faster movement of food from the stomach into the small intestine. This dual mechanism makes it effective for both antiemetic and prokinetic purposes.","oneSentence":"Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone and enhances acetylcholine effects on gastric muscle to increase gastric contractions and accelerate gastric emptying.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:53.512Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nausea and vomiting"},{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Diabetic gastroparesis"},{"name":"Post-operative nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT02040285","phase":"PHASE4","title":"Low-dose Laxative Improves Performance and Feasibility of Computed Tomography Colonography (CTC)","status":"COMPLETED","sponsor":"Azienda Policlinico Umberto I","startDate":"2012-02","conditions":"Gastrointestinal Complication","enrollment":52},{"nctId":"NCT01984931","phase":"PHASE3","title":"Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting","status":"UNKNOWN","sponsor":"CM Chungmu Hospital","startDate":"2013-10","conditions":"Nausea, Vomiting","enrollment":45}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"DIARRHOEA"},{"count":2,"reaction":"EPISTAXIS"},{"count":2,"reaction":"FEBRILE NEUTROPENIA"},{"count":2,"reaction":"PYREXIA"},{"count":2,"reaction":"THROMBOCYTOPENIA"},{"count":1,"reaction":"ABDOMINAL PAIN"},{"count":1,"reaction":"ANTITHROMBIN III DECREASED"},{"count":1,"reaction":"ATRIAL FIBRILLATION"},{"count":1,"reaction":"COLITIS"},{"count":1,"reaction":"HYPOGAMMAGLOBULINAEMIA"}],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Reglan","primperan injection"],"phase":"marketed","status":"active","brandName":"Metoclopramide hydrochloride monohydrate","genericName":"Metoclopramide hydrochloride monohydrate","companyName":"CM Chungmu Hospital","companyId":"cm-chungmu-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metoclopramide blocks dopamine receptors in the chemoreceptor trigger zone and enhances acetylcholine effects on gastric muscle to increase gastric contractions and accelerate gastric emptying. Used for Nausea and vomiting, Gastroesophageal reflux disease (GERD), Diabetic gastroparesis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}