{"id":"metizoline","rwe":[],"tags":[{"label":"metizoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Nischarin","category":"target"},{"label":"NISCH","category":"gene"},{"label":"R01AA10","category":"atc"},{"label":"Active","category":"status"},{"label":"Nasal congestion","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"benazolin","offLabel":[],"synonyms":["metizoline monohydrochloride","metizoline","benazolin","benazoline","metizolin","metizoline hydrochloride","metizoline HCl"],"timeline":[],"approvals":[],"brandName":"Benazolin","ecosystem":[{"indication":"Nasal congestion","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"target":"Nischarin","targets":[{"gene":"NISCH","source":"DrugCentral","target":"Nischarin","protein":"Nischarin"}],"modality":"Small Molecule","drugClass":"metizoline","explanation":"Imagine your nose has tiny blood vessels that swell up when you're congested. Benazolin helps to reduce this swelling by blocking the signals that tell these blood vessels to get bigger. This makes it easier to breathe through your nose.","oneSentence":"Benazolin works by blocking the action of histamine and other substances that cause nasal congestion.","technicalDetail":"Benazolin exerts its effects by competitively inhibiting the action of histamine and other endogenous substances at the Nischarin receptor, leading to vasoconstriction and reduced nasal congestion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4671","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METIZOLINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:41:40.462823","biosimilars":[],"competitors":[{"drugName":"ephedrine","drugSlug":"ephedrine","fdaApproval":"","patentExpiry":"May 16, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"phenylephrine","drugSlug":"phenylephrine","fdaApproval":"1952-01-21","patentExpiry":"Sep 26, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxymetazoline","drugSlug":"oxymetazoline","fdaApproval":"1986-05-30","patentExpiry":"May 2, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tetryzoline","drugSlug":"tetryzoline","fdaApproval":"1979-11-30","relationship":"same-class"},{"drugName":"xylometazoline","drugSlug":"xylometazoline","fdaApproval":"","relationship":"same-class"},{"drugName":"naphazoline","drugSlug":"naphazoline","fdaApproval":"1971-06-07","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"epinephrine","drugSlug":"epinephrine","fdaApproval":"1948-11-19","patentExpiry":"Oct 20, 2036","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"metizoline","indications":{"approved":[{"name":"Nasal congestion","source":"DrugCentral","snomedId":68235000,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ephedrine","brandName":"ephedrine","genericName":"ephedrine","approvalYear":"","relationship":"same-class"},{"drugId":"phenylephrine","brandName":"phenylephrine","genericName":"phenylephrine","approvalYear":"1952","relationship":"same-class"},{"drugId":"oxymetazoline","brandName":"oxymetazoline","genericName":"oxymetazoline","approvalYear":"1986","relationship":"same-class"},{"drugId":"tetryzoline","brandName":"tetryzoline","genericName":"tetryzoline","approvalYear":"1979","relationship":"same-class"},{"drugId":"xylometazoline","brandName":"xylometazoline","genericName":"xylometazoline","approvalYear":"","relationship":"same-class"},{"drugId":"naphazoline","brandName":"naphazoline","genericName":"naphazoline","approvalYear":"1971","relationship":"same-class"},{"drugId":"epinephrine","brandName":"epinephrine","genericName":"epinephrine","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"Z27L8N105U","CHEBI":"CHEBI:136017","INN_ID":"2380","UMLSCUI":"C0604284","ChEMBL_ID":"CHEMBL1370446","KEGG_DRUG":"D05006","DRUGBANK_ID":"DB13614","PUBCHEM_CID":"28688","SECONDARY_CAS_RN":"3813-05-6","MESH_SUPPLEMENTAL_RECORD_UI":"C010242"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"R01AA10","allCodes":["R01AA10"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benazolin, also known as Metizoline, is a small molecule drug that targets Nischarin. It belongs to the metizoline class and is used to treat nasal congestion. The commercial status of Benazolin is currently unknown, and it is not FDA-approved. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand the characteristics of Benazolin.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}