{"id":"metisazone","rwe":[{"pmid":"35867047","year":"2022","title":"Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst.","finding":"","journal":"Organic letters","studyType":"Clinical Study"},{"pmid":"31475759","year":"2019","title":"Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives.","finding":"","journal":"Archiv der Pharmazie","studyType":"Clinical Study"},{"pmid":"3228282","year":"1988","title":"The efficacy of amantadine and other antiviral compounds against two salmonid viruses in vitro.","finding":"","journal":"Antiviral research","studyType":"Clinical Study"},{"pmid":"999472","year":"1976","title":"The antiviral activity of isatin beta-thiosemicarbazone derivatives on vaccinia virus infection in mice.","finding":"","journal":"Archivum immunologiae et therapiae experimentalis","studyType":"Clinical Study"},{"pmid":"1085227","year":"1975","title":"Arenavirus chemotherapy--retrospect and prospect.","finding":"","journal":"Bulletin of the World Health Organization","studyType":"Clinical Study"}],"tags":[{"label":"metisazone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J05AA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiviral Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metisazon","offLabel":[],"synonyms":["methisazone","isathizone","metisazon","metisazone","metisazonum"],"timeline":[],"approvals":[],"brandName":"Metisazon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"metisazone","explanation":"Think of it like a copy machine: metisazone blocks the machine's ability to make copies of the bacterial DNA, which ultimately stops the bacteria from growing and multiplying. This is a common way that antibiotics work, but more research is needed to fully understand how metisazone fits into this process.","oneSentence":"Metisazone works by inhibiting bacterial DNA synthesis, but the exact details of this process are not well understood.","technicalDetail":"Metisazone is believed to exert its antibacterial effects by inhibiting the enzyme DNA gyrase, which is essential for bacterial DNA replication and transcription."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1746","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=metisazone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:41:35.655696","biosimilars":[],"competitors":[],"genericName":"metisazone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"K3QML4J07E","CHEBI":"CHEBI:134952","INN_ID":"1742","UMLSCUI":"C0025656","ChEMBL_ID":"CHEMBL1512080","KEGG_DRUG":"D02496","DRUGBANK_ID":"DB13641","PUBCHEM_CID":"667492","SNOMEDCT_US":"47180000","MESH_DESCRIPTOR_UI":"D008720"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J05AA01","allCodes":["J05AA01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022 Aug 5","pmid":"35867047","title":"Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst.","journal":"Organic letters"},{"date":"2019 Nov","pmid":"31475759","title":"Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives.","journal":"Archiv der Pharmazie"},{"date":"1988 Sep","pmid":"3228282","title":"The efficacy of amantadine and other antiviral compounds against two salmonid viruses in vitro.","journal":"Antiviral research"},{"date":"1976","pmid":"999472","title":"The antiviral activity of isatin beta-thiosemicarbazone derivatives on vaccinia virus infection in mice.","journal":"Archivum immunologiae et therapiae experimentalis"},{"date":"1975","pmid":"1085227","title":"Arenavirus chemotherapy--retrospect and prospect.","journal":"Bulletin of the World Health Organization"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Methisazone, also known as metisazone, is a small molecule antiviral drug that inhibits mRNA and protein synthesis, particularly in pox viruses. It was tested in the 1960s for its effectiveness against smallpox infection, but its use was limited due to logistical challenges in developing countries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}