{"id":"metipranolol","rwe":[{"pmid":"39407515","year":"2024","title":"Application of UHPLC-QqQ-MS/MS Method for Quantification of Beta-Adrenergic Blocking Agents (β-Blockers) in Human Postmortem Specimens.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"30000214","year":"2006","title":"Metipranolol.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"34112223","year":"2021","title":"Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.","finding":"","journal":"Critical care (London, England)","studyType":"Clinical Study"},{"pmid":"31928041","year":"2019","title":"Norepinephrine turnover in the left ventricle of subtotally nephrectomized rats.","finding":"","journal":"Physiological research","studyType":"Clinical Study"},{"pmid":"31770361","year":"2019","title":"Drugs for common eye disorders.","finding":"","journal":"The Medical letter on drugs and therapeutics","studyType":"Clinical Study"}],"tags":[{"label":"beta-Adrenergic Blocker","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"ADRB2","category":"gene"},{"label":"C07BA68","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Mature","category":"status"},{"label":"Ocular hypertension","category":"indication"},{"label":"Open-angle glaucoma","category":"indication"},{"label":"Bausch And Lomb","category":"company"},{"label":"Approved 1980s","category":"decade"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sympatholytics","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Acute cerebrovascular insufficiency","Anaphylaxis","Asthma","Cardiogenic shock","Chronic bronchitis","Chronic heart failure","Chronic obstructive lung disease","Complete atrioventricular block","Decompensated cardiac failure","Diabetes mellitus","Hyperthyroidism","Myasthenia gravis","Pregnancy, function","Pulmonary emphysema","Second degree atrioventricular block","Severe chronic obstructive pulmonary disease","Sinus bradycardia"]},"trials":[],"aliases":[],"company":"Bausch Health","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=METIPRANOLOL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T02:09:56.084168+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T02:10:02.775719+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METIPRANOLOL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T02:10:03.574577+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1291/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T02:10:04.033596+00:00"}},"allNames":"optipranolol","offLabel":[],"synonyms":["metipranolol hydrochloride","metipranolol","DL-Metipranolol","methypranol","trimepranol","metipranolol HCl"],"timeline":[{"date":"1989-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from BAUSCH AND LOMB to Bausch And Lomb"},{"date":"1989-12-29","type":"positive","source":"DrugCentral","milestone":"FDA approval (Bausch And Lomb)"},{"date":"2001-08-06","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 1 manufacturer approved"}],"aiSummary":"Optipranolol (Metipranolol) is a small molecule beta-adrenergic blocker developed by Bausch and Lomb. It targets the beta-1 adrenergic receptor to treat ocular hypertension and open-angle glaucoma. As an off-patent medication, it is available as a generic option. Optipranolol is used to reduce intraocular pressure by decreasing the production of aqueous humor in the eye. It has been FDA-approved since 1989.","approvals":[{"date":"1989-12-29","orphan":false,"company":"BAUSCH AND LOMB","regulator":"FDA"}],"brandName":"Optipranolol","ecosystem":[{"indication":"Ocular hypertension","otherDrugs":[{"name":"betaxolol","slug":"betaxolol","company":"Alcon"},{"name":"bimatoprost","slug":"bimatoprost","company":""},{"name":"brimonidine","slug":"brimonidine","company":""},{"name":"brinzolamide","slug":"brinzolamide","company":"Alcon Pharms Ltd"}],"globalPrevalence":1280000000},{"indication":"Open-angle glaucoma","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"apraclonidine","slug":"apraclonidine","company":"Alcon"},{"name":"betaxolol","slug":"betaxolol","company":"Alcon"},{"name":"bimatoprost","slug":"bimatoprost","company":""}],"globalPrevalence":null}],"mechanism":{"target":"Beta-1 adrenergic receptor","novelty":"Follow-on","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"}],"moaClass":"Adrenergic beta-Antagonists","modality":"Small Molecule","drugClass":"beta-Adrenergic Blocker","explanation":"","oneSentence":"","technicalDetail":"Optipranolol is a non-selective beta-adrenergic blocker that competes with endogenous catecholamines for binding to the beta-1 adrenergic receptor, thereby inhibiting the adenylate cyclase activity and reducing the production of aqueous humor in the ciliary epithelium."},"commercial":{"launchDate":"1989","_launchSource":"DrugCentral (FDA 1989-12-29, BAUSCH AND 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