{"id":"metipamide","rwe":[{"pmid":"2763478","year":"1989","title":"[Antihypertensive therapy using metipamide VUFB].","finding":"","journal":"Vnitrni lekarstvi","studyType":"Clinical Study"},{"pmid":"2765961","year":"1989","title":"[The effect of metipamide on levels of sodium and potassium in erythrocytes].","finding":"","journal":"Bratislavske lekarske listy","studyType":"Clinical Study"},{"pmid":"2715287","year":"1989","title":"Therapeutic monitoring of metipamide during antihypertensive therapy.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"},{"pmid":"2975004","year":"1988","title":"The diuretic effect of metipamide and its relationship to body weights in rats.","finding":"","journal":"Physiologia Bohemoslovaca","studyType":"Clinical Study"},{"pmid":"3756564","year":"1986","title":"[The effect of short-term administration of metipamide in patients with hypertension who were evaluated by non-invasive examination of the cardiovascular system].","finding":"","journal":"Bratislavske lekarske listy","studyType":"Clinical Study"}],"tags":[{"label":"metipamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hypotylin","offLabel":[],"synonyms":["metipamid","hypotylin","metipamide"],"timeline":[],"approvals":[],"brandName":"Hypotylin","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"metipamide","explanation":"Think of it like a fire extinguisher for your stomach. Metipamide helps put out the flames of acid production, which can help reduce symptoms of conditions like heartburn and acid reflux. This can make it easier to digest food and reduce discomfort.","oneSentence":"Metipamide works by inhibiting gastric acid secretion, reducing the amount of acid produced in the stomach.","technicalDetail":"Metipamide acts as a histamine H2-receptor antagonist, competitively inhibiting histamine binding to H2 receptors on parietal cells in the stomach, thereby reducing gastric acid secretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1778","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=metipamide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:26:55.001512","biosimilars":[],"competitors":[],"genericName":"metipamide","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"N9Q32YUR4E","CHEBI":"CHEBI:135441","UMLSCUI":"C0066454","ChEMBL_ID":"CHEMBL1200940","PUBCHEM_CID":"135086","MESH_SUPPLEMENTAL_RECORD_UI":"C050506"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":6,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"1989 May","pmid":"2763478","title":"[Antihypertensive therapy using metipamide VUFB].","journal":"Vnitrni lekarstvi"},{"date":"1989 Apr","pmid":"2765961","title":"[The effect of metipamide on levels of sodium and potassium in erythrocytes].","journal":"Bratislavske lekarske listy"},{"date":"1989 Mar 17","pmid":"2715287","title":"Therapeutic monitoring of metipamide during antihypertensive therapy.","journal":"Journal of chromatography"},{"date":"1988","pmid":"2975004","title":"The diuretic effect of metipamide and its relationship to body weights in rats.","journal":"Physiologia Bohemoslovaca"},{"date":"1986 Sep","pmid":"3756564","title":"[The effect of short-term administration of metipamide in patients with hypertension who were evaluated by non-invasive examination of the cardiovascular system].","journal":"Bratislavske lekarske listy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Hypotylin (metipamide) is a small molecule drug in the metipamide class, originally developed by an unknown entity and currently owned by an unknown entity. It is used to treat hypertensive disorders. The commercial status of Hypotylin is unknown, and it is not clear if it is patented or available as a generic medication. Key safety considerations for Hypotylin are not well-documented. Further research is needed to fully understand its pharmacology and clinical use.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}