{"id":"metildigoxin","rwe":[{"pmid":"34664726","year":"2022","title":"Detecting drug-drug interactions that increase the incidence of long QT syndrome using a spontaneous reporting system.","finding":"","journal":"Journal of clinical pharmacy and therapeutics","studyType":"Clinical Study"},{"pmid":"24889325","year":"2014","title":"Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry.","finding":"","journal":"Forensic science international","studyType":"Clinical Study"},{"pmid":"21776271","year":"2012","title":"Analysis of digoxin and metildigoxin in whole blood using solid-phase extraction and liquid chromatography tandem mass spectrometry.","finding":"","journal":"International journal of analytical chemistry","studyType":"Clinical Study"},{"pmid":"15704612","year":"2005","title":"Interactions between clarithromycin and digoxin in patients with end-stage renal disease.","finding":"","journal":"International journal of clinical pharmacology and therapeutics","studyType":"Clinical Study"},{"pmid":"11021271","year":"1999","title":"[Hypocalcemia-induced heart failure as the initial symptom of hypoparathyroidism].","finding":"","journal":"Zeitschrift fur Kardiologie","studyType":"Clinical Study"}],"tags":[{"label":"metildigoxin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sodium/potassium-transporting ATPase subunit alpha-1","category":"target"},{"label":"ATP1A1","category":"gene"},{"label":"C01AA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":108.922,"date":"","count":64,"signal":"Cardiac failure","source":"DrugCentral FAERS","actionTaken":"Reported 64 times (LLR=109)"},{"llr":75.469,"date":"","count":23,"signal":"Cardiac failure chronic","source":"DrugCentral FAERS","actionTaken":"Reported 23 times (LLR=75)"},{"llr":56.681,"date":"","count":15,"signal":"N-terminal prohormone brain natriuretic peptide increased","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=57)"},{"llr":52.183,"date":"","count":14,"signal":"Wound haemorrhage","source":"DrugCentral FAERS","actionTaken":"Reported 14 times (LLR=52)"},{"llr":48.976,"date":"","count":10,"signal":"Toxic neuropathy","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=49)"},{"llr":46.263,"date":"","count":35,"signal":"Bradycardia","source":"DrugCentral FAERS","actionTaken":"Reported 35 times (LLR=46)"},{"llr":43.702,"date":"","count":9,"signal":"Refractory anaemia with an excess of blasts","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=44)"},{"llr":42.994,"date":"","count":14,"signal":"Aortic stenosis","source":"DrugCentral FAERS","actionTaken":"Reported 14 times (LLR=43)"},{"llr":41.701,"date":"","count":15,"signal":"Congestive cardiomyopathy","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=42)"},{"llr":41.093,"date":"","count":22,"signal":"Cerebral infarction","source":"DrugCentral FAERS","actionTaken":"Reported 22 times (LLR=41)"},{"llr":36.053,"date":"","count":12,"signal":"Embolic stroke","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=36)"},{"llr":32.733,"date":"","count":78,"signal":"Dyspnoea","source":"DrugCentral FAERS","actionTaken":"Reported 78 times (LLR=33)"},{"llr":30.727,"date":"","count":40,"signal":"General physical health deterioration","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=31)"},{"llr":29.067,"date":"","count":10,"signal":"Dyspnoea at rest","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=29)"},{"llr":29.004,"date":"","count":9,"signal":"Micturition disorder","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=29)"}],"commonSideEffects":[{"effect":"Cardiac failure","drugRate":"LLR 109","severity":"common"},{"effect":"N-terminal prohormone brain natriuretic peptide increased","drugRate":"LLR 57","severity":"common"},{"effect":"Wound haemorrhage","drugRate":"LLR 52","severity":"common"},{"effect":"Toxic neuropathy","drugRate":"LLR 49","severity":"common"},{"effect":"Bradycardia","drugRate":"LLR 46","severity":"common"},{"effect":"Refractory anaemia with an excess of blasts","drugRate":"LLR 44","severity":"common"},{"effect":"Aortic stenosis","drugRate":"LLR 43","severity":"common"},{"effect":"Congestive cardiomyopathy","drugRate":"LLR 42","severity":"common"},{"effect":"Cerebral infarction","drugRate":"LLR 41","severity":"common"},{"effect":"Embolic stroke","drugRate":"LLR 36","severity":"common"},{"effect":"Dyspnoea","drugRate":"LLR 33","severity":"common"},{"effect":"General physical health deterioration","drugRate":"LLR 31","severity":"common"},{"effect":"Micturition disorder","drugRate":"LLR 29","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lanitop","offLabel":[],"synonyms":["methyldigoxin","metildigoxin","4'-Methyldigoxin","lanirapid","lanitop","medigoxin","beta-Methyldigoxin"],"timeline":[],"aiSummary":"Lanitop, also known as metildigoxin, is a small molecule drug that targets the sodium/potassium-transporting ATPase subunit alpha-1. It is a member of the metildigoxin class and works by inhibiting the sodium-potassium pump, leading to increased levels of potassium and decreased levels of sodium in the heart. However, due to the lack of available information, its commercial status, approved indications, half-life, bioavailability, and generic manufacturers are unknown. Lanitop's safety considerations and efficacy are also not well-documented. Further research is needed to fully understand this medication.","approvals":[],"brandName":"Lanitop","ecosystem":[],"mechanism":{"target":"Sodium/potassium-transporting ATPase subunit alpha-1","targets":[{"gene":"ATP1A1","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase subunit alpha-1","protein":"Sodium/potassium-transporting ATPase subunit alpha-1"}],"modality":"Small Molecule","drugClass":"metildigoxin","explanation":"Think of the sodium-potassium pump like a gatekeeper that controls the flow of sodium and potassium ions in and out of the heart cells. When Lanitop blocks this pump, it allows more potassium to enter the cells and less sodium to leave, which can help slow down the heart rate and improve its function.","oneSentence":"Lanitop works by blocking the sodium-potassium pump in the heart, which helps regulate the balance of sodium and potassium ions.","technicalDetail":"Lanitop inhibits the sodium/potassium-transporting ATPase subunit alpha-1, leading to increased intracellular potassium and decreased intracellular sodium, which can result in a decrease in heart rate and an increase in contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1761","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METILDIGOXIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:41:23.472314","biosimilars":[],"competitors":[{"drugName":"acetyldigitoxin","drugSlug":"acetyldigitoxin","fdaApproval":"1975-04-24","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"digitoxin","drugSlug":"digitoxin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"digoxin","drugSlug":"digoxin","fdaApproval":"1975-10-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"deslanoside","drugSlug":"deslanoside","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"metildigoxin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acetyldigitoxin","brandName":"acetyldigitoxin","genericName":"acetyldigitoxin","approvalYear":"1975","relationship":"same-class"},{"drugId":"digitoxin","brandName":"digitoxin","genericName":"digitoxin","approvalYear":"","relationship":"same-class"},{"drugId":"digoxin","brandName":"digoxin","genericName":"digoxin","approvalYear":"1975","relationship":"same-class"},{"drugId":"deslanoside","brandName":"deslanoside","genericName":"deslanoside","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000168450","NDDF":"006744","UNII":"I7GG1YUC5V","CHEBI":"CHEBI:135885","INN_ID":"2876","RXNORM":"6686","UMLSCUI":"C0025132","ChEMBL_ID":"CHEMBL1697843","KEGG_DRUG":"D02587","DRUGBANK_ID":"DB13401","PUBCHEM_CID":"443946","SNOMEDCT_US":"317911001","MESH_DESCRIPTOR_UI":"D008520"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":15,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C01AA08","allCodes":["C01AA08"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022 Jan","pmid":"34664726","title":"Detecting drug-drug interactions that increase the incidence of long QT syndrome using a spontaneous reporting system.","journal":"Journal of clinical pharmacy and therapeutics"},{"date":"2014 Aug","pmid":"24889325","title":"Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry.","journal":"Forensic science international"},{"date":"2012","pmid":"21776271","title":"Analysis of digoxin and metildigoxin in whole blood using solid-phase extraction and liquid chromatography tandem mass spectrometry.","journal":"International journal of analytical chemistry"},{"date":"2005 Jan","pmid":"15704612","title":"Interactions between clarithromycin and digoxin in patients with end-stage renal disease.","journal":"International journal of clinical pharmacology and therapeutics"},{"date":"1999 Jan","pmid":"11021271","title":"[Hypocalcemia-induced heart failure as the initial symptom of hypoparathyroidism].","journal":"Zeitschrift fur Kardiologie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}