{"id":"methyprednisolone-sodium-succinate","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Insomnia"},{"rate":"5-10%","effect":"Increased blood pressure"}]},"_chembl":{"chemblId":"CHEMBL1200345","moleculeType":"Small molecule","molecularWeight":"140.07"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by binding to glucocorticoid receptors in the cytoplasm, which then translocate to the nucleus and inhibit the transcription of inflammatory genes. This leads to a decrease in the production of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-alpha, resulting in reduced inflammation and immune response.","oneSentence":"Methylprednisolone sodium succinate is a corticosteroid that suppresses the immune system by inhibiting the production of inflammatory cytokines.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:07.610Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Severe asthma attacks"},{"name":"Severe allergic reactions (anaphylaxis)"},{"name":"Severe skin conditions (such as psoriasis or eczema)"},{"name":"Severe respiratory conditions (such as COPD or bronchitis)"},{"name":"Severe inflammatory conditions (such as rheumatoid arthritis or lupus)"}]},"trialDetails":[{"nctId":"NCT06870448","phase":"PHASE3","title":"Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2025-04","conditions":"Acute Ischemic Stroke","enrollment":1614}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"CONDITION AGGRAVATED"},{"count":2,"reaction":"PYREXIA"},{"count":1,"reaction":"AGRANULOCYTOSIS"},{"count":1,"reaction":"ANAEMIA POSTOPERATIVE"},{"count":1,"reaction":"APHASIA"},{"count":1,"reaction":"APHTHOUS STOMATITIS"},{"count":1,"reaction":"APNOEA NEONATAL"},{"count":1,"reaction":"BRADYCARDIA"},{"count":1,"reaction":"BRAIN OEDEMA"},{"count":1,"reaction":"CARDIAC ARREST"}],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Methylprednisolone"],"phase":"phase_3","status":"active","brandName":"Methyprednisolone sodium succinate","genericName":"Methyprednisolone sodium succinate","companyName":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","companyId":"sun-yat-sen-memorial-hospital-of-sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylprednisolone sodium succinate is a corticosteroid that suppresses the immune system by inhibiting the production of inflammatory cytokines. Used for Severe asthma attacks, Severe allergic reactions (anaphylaxis), Severe skin conditions (such as psoriasis or eczema).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}