{"id":"methylthiouracil","rwe":[],"tags":[{"label":"methylthiouracil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"H03BA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Antithyroid Agents","category":"pharmacology"},{"label":"Hormone Antagonists","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"thiomecil","offLabel":[],"synonyms":["methylthiouracil","thiomecil","6-Methyl-2-thiouracil","thiothymin"],"timeline":[],"approvals":[],"brandName":"Thiomecil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"methylthiouracil","explanation":"Think of it like a brake on a car - Thiomecil slows down the production of thyroid hormones, which can help reduce symptoms of overactive thyroid conditions. This is achieved by blocking the enzyme that converts iodine into thyroid hormones, effectively reducing the amount of hormones produced.","oneSentence":"Thiomecil works by inhibiting the synthesis of thyroid hormones.","technicalDetail":"Thiomecil exerts its effects by inhibiting the enzyme thyroid peroxidase (TPO), which is essential for the synthesis of thyroid hormones T3 and T4 from iodine and tyrosine residues on thyroglobulin."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1773","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYLTHIOURACIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:40:56.752266","biosimilars":[],"competitors":[{"drugName":"propylthiouracil","drugSlug":"propylthiouracil","fdaApproval":"1947-07-28","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"methylthiouracil","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"propylthiouracil","brandName":"propylthiouracil","genericName":"propylthiouracil","approvalYear":"1947","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002138","UNII":"QW24888U5F","CHEBI":"CHEBI:82346","INN_ID":"4150","UMLSCUI":"C0025830","ChEMBL_ID":"CHEMBL1330588","KEGG_DRUG":"D07231","DRUGBANK_ID":"DB13644","PUBCHEM_CID":"667493","SNOMEDCT_US":"387356006","MESH_DESCRIPTOR_UI":"D008779","MESH_SUPPLEMENTAL_RECORD_UI":"C000599236"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":632,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"H03BA01","allCodes":["H03BA01"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thiomecil, also known as Methylthiouracil, is a small molecule drug in the methylthiouracil class. Its exact target is unknown, but it is used to treat certain thyroid conditions. The commercial status of Thiomecil is unclear, and it may be available as a generic medication. Key safety considerations include potential liver damage and interactions with other medications. Further research is needed to fully understand its pharmacological properties.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}