{"id":"methylprednisolone-or-budesonide","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Hypertension (methylprednisolone)"},{"rate":null,"effect":"Adrenal suppression (with prolonged systemic use)"},{"rate":null,"effect":"Increased infection risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone is a systemic corticosteroid with potent anti-inflammatory and immunosuppressive effects used for moderate-to-severe IBD. Budesonide is a topically-acting corticosteroid with high first-pass hepatic metabolism, allowing targeted delivery to the colon with reduced systemic exposure. Both reduce intestinal inflammation through glucocorticoid receptor activation, though budesonide offers a more favorable safety profile due to its local action and rapid metabolism.","oneSentence":"Both methylprednisolone and budesonide are corticosteroids that suppress immune and inflammatory responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:54.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory bowel disease (Crohn's disease and ulcerative colitis)"},{"name":"Acute exacerbations of IBD"}]},"trialDetails":[{"nctId":"NCT03952286","phase":"PHASE4","title":"ED-Initiated School-based Asthma Medication Supervision","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2019-08-01","conditions":"Asthma, Asthma in Children","enrollment":13},{"nctId":"NCT06676384","phase":"PHASE4","title":"Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?","status":"RECRUITING","sponsor":"Christian Medical College, Vellore, India","startDate":"2025-02-15","conditions":"IgA Nephropathy, Renal Insufficiency, Chronic, IgA Vasculitis","enrollment":585},{"nctId":"NCT06126692","phase":"","title":"3TR Asthma Biologics Cohort (ABC) Study","status":"RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2022-01-10","conditions":"Severe Asthma","enrollment":600},{"nctId":"NCT00576069","phase":"","title":"Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma","status":"RECRUITING","sponsor":"Gelb, Arthur F., M.D.","startDate":"2007-10-25","conditions":"Asthma","enrollment":60},{"nctId":"NCT05164692","phase":"NA","title":"Effects of Nasal-spraying LiveSpo Navax in Treatment of Acute Respiratory Infections in Children","status":"COMPLETED","sponsor":"National Children's Hospital, Vietnam","startDate":"2020-08-29","conditions":"Acute Respiratory Tract Infections","enrollment":100},{"nctId":"NCT00388739","phase":"NA","title":"Initiation of Chronic Asthma Care Regimens in the Pediatric Emergency Department","status":"WITHDRAWN","sponsor":"Baylor College of Medicine","startDate":"2006-11-01","conditions":"Asthma","enrollment":""},{"nctId":"NCT02425813","phase":"PHASE2","title":"Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract","status":"WITHDRAWN","sponsor":"Wake Forest University Health Sciences","startDate":"2015-10","conditions":"Acute Graft Versus Host Disease, Intestinal Graft Versus Host Disease","enrollment":""},{"nctId":"NCT00672763","phase":"PHASE4","title":"Adjuvant Vitamin D With Corticosteroids in Active Crohn's Disease","status":"WITHDRAWN","sponsor":"Imperial College London","startDate":"2008-05","conditions":"Crohn's Disease","enrollment":""},{"nctId":"NCT00393367","phase":"PHASE4","title":"Budesonide Inhalation Suspension for Acute Asthma in Children","status":"COMPLETED","sponsor":"Children's Hospital of Philadelphia","startDate":"2006-12","conditions":"Asthma, Acute Asthma, Reactive Airway Exacerbation","enrollment":179},{"nctId":"NCT00554710","phase":"PHASE4","title":"Top Down Versus Step Up Strategies in Crohn's Disease","status":"COMPLETED","sponsor":"Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW","startDate":"2001-05","conditions":"Crohn's Disease","enrollment":129}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40551,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Medrol, entocort, budenofalk"],"phase":"marketed","status":"active","brandName":"methylprednisolone or budesonide","genericName":"methylprednisolone or budesonide","companyName":"Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW","companyId":"belgian-inflammatory-bowel-disease-research-and-development-bird-vzw","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Both methylprednisolone and budesonide are corticosteroids that suppress immune and inflammatory responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory bowel disease (Crohn's disease and ulcerative colitis), Acute exacerbations of IBD.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}