{"id":"methylprednisolone-injection-solu-medrol","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes (euphoria, depression)"},{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hypokalemia"}]},"_chembl":{"chemblId":"CHEMBL1201081","moleculeType":"Small molecule","molecularWeight":"496.53"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone acts as a glucocorticoid receptor agonist, translocating to the nucleus to modulate gene expression of inflammatory mediators. It inhibits phospholipase A2, reducing prostaglandin and leukotriene synthesis, and suppresses T-cell proliferation and antibody production. This broad immunosuppressive and anti-inflammatory effect makes it useful across multiple inflammatory and autoimmune conditions.","oneSentence":"Methylprednisolone is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:49.129Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)"},{"name":"Acute exacerbations of multiple sclerosis"},{"name":"Cerebral edema"},{"name":"Severe allergic reactions"},{"name":"Adrenocortical insufficiency"},{"name":"Organ transplant rejection prophylaxis"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":131,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lidocaine, 1% solution"],"phase":"marketed","status":"active","brandName":"Methylprednisolone Injection [Solu-Medrol]","genericName":"Methylprednisolone Injection [Solu-Medrol]","companyName":"Mercy Health Ohio","companyId":"mercy-health-ohio","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylprednisolone is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Acute exacerbations of multiple sclerosis, Cerebral edema.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}