{"id":"methylprednisolone-injectable-suspension","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Mood changes (euphoria, anxiety)"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Immunosuppression / increased infection risk"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone exerts its anti-inflammatory and immunosuppressive effects by entering cells and binding to cytoplasmic glucocorticoid receptors, which then translocate to the nucleus and modulate gene transcription. This leads to decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and reduced immune cell activation and proliferation. The injectable suspension formulation allows for rapid systemic delivery and is commonly used for acute inflammatory and autoimmune conditions requiring high-dose corticosteroid therapy.","oneSentence":"Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:59.015Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute inflammatory and autoimmune disorders"},{"name":"Multiple sclerosis exacerbations"},{"name":"Severe allergic reactions"},{"name":"Rheumatoid arthritis and other rheumatologic conditions"},{"name":"Cerebral edema"}]},"trialDetails":[{"nctId":"NCT05058287","phase":"PHASE3","title":"Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2021-11-05","conditions":"Opioid Use, Lumbar Spinal Stenosis, Pain, Postoperative","enrollment":150},{"nctId":"NCT07151417","phase":"PHASE2, PHASE3","title":"Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Walter Reed National Military Medical Center","startDate":"2025-09-01","conditions":"Knee Osteoarthritis, Musculoskeletal Disease, Surgery","enrollment":240},{"nctId":"NCT06474416","phase":"PHASE1","title":"A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shanghai BDgene Co., Ltd.","startDate":"2023-09-04","conditions":"Herpes Simplex Virus Type I Stromal Keratitis","enrollment":16},{"nctId":"NCT05191706","phase":"PHASE4","title":"Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract","status":"RECRUITING","sponsor":"EyePoint Pharmaceuticals, Inc.","startDate":"2022-01-04","conditions":"Cataract","enrollment":60},{"nctId":"NCT04622917","phase":"PHASE4","title":"Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis.","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2019-04-10","conditions":"Rhinitis, Allergic, Seasonal, Hay Fever, Pollen Allergy","enrollment":44},{"nctId":"NCT03511625","phase":"PHASE3","title":"The Effects of Acthar on Synovial Inflammation in Rheumatoid Arthritis","status":"UNKNOWN","sponsor":"Attune Health Research, Inc.","startDate":"2018-10-02","conditions":"Rheumatoid Arthritis","enrollment":6},{"nctId":"NCT06189586","phase":"NA","title":"Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD","status":"UNKNOWN","sponsor":"Dong Yang","startDate":"2021-10-01","conditions":"Acute Exacerbation of Chronic Obstructive Pulmonary Disease","enrollment":100},{"nctId":"NCT05752305","phase":"PHASE2, PHASE3","title":"Use of Corticosteroids in Third Molar Surgery","status":"COMPLETED","sponsor":"Universidad de Granada","startDate":"2022-01-15","conditions":"Inflammation, Pain, Postoperative, Trismus","enrollment":84},{"nctId":"NCT05863936","phase":"PHASE3","title":"Trial of Belimumab Combined With Multi-target Induction Therapy in Lupus Nephritis","status":"UNKNOWN","sponsor":"Nanjing University School of Medicine","startDate":"2023-04-01","conditions":"Lupus Nephritis, Remission, Safety Issues","enrollment":15},{"nctId":"NCT03704584","phase":"PHASE4","title":"Corticosteroid(CS) + Lido or Corticosteroid(CS) Alone","status":"TERMINATED","sponsor":"Emory University","startDate":"2019-05-14","conditions":"Tenosynovitis","enrollment":62},{"nctId":"NCT05291793","phase":"NA","title":"The Effect of Different Intra-articular Injections Primary Gonarthrosis","status":"COMPLETED","sponsor":"Nevsehir Haci Bektas Veli University","startDate":"2020-04-01","conditions":"Gonarthrosis; 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Used for Acute inflammatory and autoimmune disorders, Multiple sclerosis exacerbations, Severe allergic reactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}