{"id":"methylprednisolone-aceponate","rwe":[{"pmid":"41860390","year":"2026","title":"Development and Validation of a Stability-Indicating Reversed-Phase Liquid Chromatographic Method for the Simultaneous Determination of Methylprednisolone Aceponate and Benzyl Alcohol in Cream Formulation.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"},{"pmid":"41688780","year":"2026","title":"Development and validation of a method to quantify methylprednisolone aceponate in cream by micellar liquid chromatography.","finding":"","journal":"Analytical and bioanalytical chemistry","studyType":"Clinical Study"},{"pmid":"41187336","year":"2025","title":"[Generalized pustular psoriasis: a rare entity in pediatrics].","finding":"","journal":"Boletin medico del Hospital Infantil de Mexico","studyType":"Clinical Study"},{"pmid":"40862424","year":"2025","title":"Randomized clinical trial comparing removal followed by topical imiquimod versus removal followed by topical methylprednisolone in the treatment of keloids.","finding":"","journal":"Acta cirurgica brasileira","studyType":"Clinical Study"},{"pmid":"40738245","year":"2026","title":"Effect of Systemic Therapies on Skin Bacteriome in Patients with Atopic Dermatitis: A Pilot Prospective Study.","finding":"","journal":"The Journal of investigative dermatology","studyType":"Clinical Study"}],"tags":[{"label":"Corticosteroid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D07AC14","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Antiemetics","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"},{"label":"Neuroprotective Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":107.967,"date":"","count":17,"signal":"Steroid withdrawal syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 17 times (LLR=108)"},{"llr":56.219,"date":"","count":15,"signal":"Euphoric mood","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=56)"},{"llr":54.084,"date":"","count":11,"signal":"Pelvic venous thrombosis","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=54)"},{"llr":53.037,"date":"","count":10,"signal":"Coagulation test abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=53)"},{"llr":52.084,"date":"","count":13,"signal":"Stupor","source":"DrugCentral FAERS","actionTaken":"Reported 13 times (LLR=52)"},{"llr":50.165,"date":"","count":10,"signal":"Erythrodermic psoriasis","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=50)"},{"llr":33.321,"date":"","count":5,"signal":"Total bile acids increased","source":"DrugCentral FAERS","actionTaken":"Reported 5 times (LLR=33)"},{"llr":33.306,"date":"","count":24,"signal":"Pulmonary embolism","source":"DrugCentral FAERS","actionTaken":"Reported 24 times (LLR=33)"},{"llr":31.886,"date":"","count":16,"signal":"Disorientation","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=32)"},{"llr":31.322,"date":"","count":15,"signal":"Transaminases increased","source":"DrugCentral FAERS","actionTaken":"Reported 15 times (LLR=31)"}],"commonSideEffects":[{"effect":"Steroid withdrawal syndrome","drugRate":"LLR 108","severity":"common"},{"effect":"Euphoric mood","drugRate":"LLR 56","severity":"common"},{"effect":"Pelvic venous thrombosis","drugRate":"LLR 54","severity":"common"},{"effect":"Coagulation test abnormal","drugRate":"LLR 53","severity":"common"},{"effect":"Stupor","drugRate":"LLR 52","severity":"common"},{"effect":"Erythrodermic psoriasis","drugRate":"LLR 50","severity":"common"},{"effect":"Total bile acids increased","drugRate":"LLR 33","severity":"common"},{"effect":"Pulmonary embolism","drugRate":"LLR 33","severity":"common"},{"effect":"Disorientation","drugRate":"LLR 32","severity":"common"},{"effect":"Transaminases increased","drugRate":"LLR 31","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"advantan","offLabel":[],"synonyms":["methylprednisolone aceponate","advantan"],"timeline":[],"aiSummary":"Advantan (METHYLPREDNISOLONE ACEPONATE) is a corticosteroid medication developed by Schering-Plough, currently owned by Merck & Co. It is a small molecule that works by suppressing the immune system to reduce inflammation and swelling. Advantan is used to treat various skin conditions, including eczema and atopic dermatitis. The commercial status of Advantan is patented, and its safety considerations include potential side effects such as skin thinning and increased risk of infections. As a corticosteroid, Advantan should be used under medical supervision to minimize risks.","approvals":[],"brandName":"Advantan","ecosystem":[],"mechanism":{"moaClass":"Corticosteroid Hormone Receptor Agonists","modality":"Small Molecule","drugClass":"Corticosteroid","explanation":"Imagine your immune system is like a fire alarm that goes off when it senses something wrong. Advantan helps turn down the volume on the fire alarm, reducing the inflammation and swelling that can cause discomfort and pain. This allows the skin to heal and recover more quickly.","oneSentence":"Advantan works by binding to glucocorticoid receptors in the body, which then suppresses the production of inflammatory chemicals.","technicalDetail":"METHYLPREDNISOLONE ACEPONATE is a prodrug that is converted to its active form, methylprednisolone, which then binds to glucocorticoid receptors, leading to the suppression of inflammatory gene expression and the reduction of inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1769","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=METHYLPREDNISOLONE%20ACEPONATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYLPREDNISOLONE ACEPONATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:40:08.622817","biosimilars":[],"competitors":[{"drugName":"betamethasone","drugSlug":"betamethasone","fdaApproval":"1961-04-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"desoximetasone","drugSlug":"desoximetasone","fdaApproval":"1977-02-28","patentExpiry":"Sep 1, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluocinolone acetonide","drugSlug":"fluocinolone-acetonide","fdaApproval":"1963-02-15","patentExpiry":"Nov 7, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fludroxycortide","drugSlug":"fludroxycortide","fdaApproval":"1963-03-19","relationship":"same-class"},{"drugName":"fluocinonide","drugSlug":"fluocinonide","fdaApproval":"1971-06-30","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"budesonide","drugSlug":"budesonide","fdaApproval":"1994-02-14","patentExpiry":"Sep 9, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"diflorasone diacetate","drugSlug":"diflorasone-diacetate","fdaApproval":"1977-09-14","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"amcinonide","drugSlug":"amcinonide","fdaApproval":"1979-10-18","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mometasone furoate","drugSlug":"mometasone-furoate","fdaApproval":"1987-04-30","patentExpiry":"Oct 3, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"beclometasone dipropionate","drugSlug":"beclometasone-dipropionate","fdaApproval":"1976-05-12","relationship":"same-class"},{"drugName":"hydrocortisone aceponate","drugSlug":"hydrocortisone-aceponate","fdaApproval":"","relationship":"same-class"},{"drugName":"fluticasone furoate","drugSlug":"fluticasone-furoate","fdaApproval":"2007-04-27","patentExpiry":"Oct 15, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"fluticasone propionate","drugSlug":"fluticasone-propionate","fdaApproval":"1990-12-14","patentExpiry":"Sep 26, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prednicarbate","drugSlug":"prednicarbate","fdaApproval":"1991-09-23","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"difluprednate","drugSlug":"difluprednate","fdaApproval":"2008-06-23","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ulobetasol propionate","drugSlug":"ulobetasol-propionate","fdaApproval":"1990-12-17","relationship":"same-class"}],"genericName":"methylprednisolone aceponate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"betamethasone","brandName":"betamethasone","genericName":"betamethasone","approvalYear":"1961","relationship":"same-class"},{"drugId":"desoximetasone","brandName":"desoximetasone","genericName":"desoximetasone","approvalYear":"1977","relationship":"same-class"},{"drugId":"fluocinolone-acetonide","brandName":"fluocinolone acetonide","genericName":"fluocinolone acetonide","approvalYear":"1963","relationship":"same-class"},{"drugId":"fludroxycortide","brandName":"fludroxycortide","genericName":"fludroxycortide","approvalYear":"1963","relationship":"same-class"},{"drugId":"fluocinonide","brandName":"fluocinonide","genericName":"fluocinonide","approvalYear":"1971","relationship":"same-class"},{"drugId":"budesonide","brandName":"budesonide","genericName":"budesonide","approvalYear":"1994","relationship":"same-class"},{"drugId":"diflorasone-diacetate","brandName":"diflorasone diacetate","genericName":"diflorasone diacetate","approvalYear":"1977","relationship":"same-class"},{"drugId":"amcinonide","brandName":"amcinonide","genericName":"amcinonide","approvalYear":"1979","relationship":"same-class"},{"drugId":"mometasone-furoate","brandName":"mometasone furoate","genericName":"mometasone furoate","approvalYear":"1987","relationship":"same-class"},{"drugId":"beclometasone-dipropionate","brandName":"beclometasone dipropionate","genericName":"beclometasone dipropionate","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02798523","phase":"PHASE1","title":"Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2017-01-24","conditions":["Normal Physiology"],"enrollment":33,"completionDate":"2022-11-14"},{"nctId":"NCT00185510","phase":"PHASE4","title":"Efficacy and Safety Study of Advantan for Maintenance Treatment of Atopic Dermatitis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2005-03","conditions":["Dermatitis, Atopic"],"enrollment":250,"completionDate":"2006-06"},{"nctId":"NCT04016025","phase":"PHASE4","title":"A Clinical Study of Adherence to Methylprednisolone Aceponate in Different Carriers","status":"COMPLETED","sponsor":"Jena University Hospital","startDate":"2020-12-02","conditions":["Adherence, Patient","Chronic Eczema"],"enrollment":80,"completionDate":"2022-04-14"},{"nctId":"NCT04900948","phase":"PHASE4","title":"Prevention of Development of Transcutaneous Sensitization in Children With Atopic Dermatitis During Their First Year of Life","status":"COMPLETED","sponsor":"National Medical Research Center for Children's Health, Russian Federation","startDate":"2017-12-10","conditions":["Atopic Dermatitis"],"enrollment":108,"completionDate":"2020-04-25"},{"nctId":"NCT01639040","phase":"PHASE2","title":"Study to Assess the Safety of Dupilumab (REGN668/SAR231893) Administered Concomitantly With Topical Corticosteroids (TCS) in Patients With Moderate-to-severe Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"Regeneron Pharmaceuticals","startDate":"2012-07","conditions":["Atopic Dermatitis"],"enrollment":31,"completionDate":"2012-12"},{"nctId":"NCT01529320","phase":"PHASE1","title":"Assess Itch Behavior in Nickel Sulphate Sensitized Volunteers","status":"COMPLETED","sponsor":"Fundacion IMIM","startDate":"2012-02","conditions":["Allergic Contact Eczema"],"enrollment":18,"completionDate":"2012-05"},{"nctId":"NCT00236171","phase":"NA","title":"Evaluation of Topical Antipsoriatics in the Psoriasis Plaque Test","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2004-09","conditions":["Psoriasis Vulgaris"],"enrollment":14,"completionDate":"2010-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"1041","NDDF":"002160","UNII":"ET54W9J4U2","CHEBI":"CHEBI:135762","VANDF":"4018068","INN_ID":"5524","RXNORM":"62136","UMLSCUI":"C0174938","ChEMBL_ID":"CHEMBL1697782","KEGG_DRUG":"D07203","DRUGBANK_ID":"DB14643","PUBCHEM_CID":"63019","SNOMEDCT_US":"116593003","MESH_DESCRIPTOR_UI":"D008775","MESH_SUPPLEMENTAL_RECORD_UI":"C078007"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":84,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D07AC14","allCodes":["D07AC14"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 May","pmid":"41860390","title":"Development and Validation of a Stability-Indicating Reversed-Phase Liquid Chromatographic Method for the Simultaneous Determination of Methylprednisolone Aceponate and Benzyl Alcohol in Cream Formulation.","journal":"Biomedical chromatography : BMC"},{"date":"2026 Feb 14","pmid":"41688780","title":"Development and validation of a method to quantify methylprednisolone aceponate in cream by micellar liquid chromatography.","journal":"Analytical and bioanalytical chemistry"},{"date":"2025 Nov 4","pmid":"41187336","title":"[Generalized pustular psoriasis: a rare entity in pediatrics].","journal":"Boletin medico del Hospital Infantil de Mexico"},{"date":"2025","pmid":"40862424","title":"Randomized clinical trial comparing removal followed by topical imiquimod versus removal followed by topical methylprednisolone in the treatment of keloids.","journal":"Acta cirurgica brasileira"},{"date":"2026 Feb","pmid":"40738245","title":"Effect of Systemic Therapies on Skin Bacteriome in Patients with Atopic Dermatitis: A Pilot Prospective Study.","journal":"The Journal of investigative dermatology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}